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Protein

Alcohol dehydrogenase

Gene

adh

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Zinc 1; catalyticBy similarity1
Metal bindingi58Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi145Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Short name:
ADH
Gene namesi
Name:adh
Ordered Locus Names:SE_0375
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002730421 – 340Alcohol dehydrogenaseAdd BLAST340

Proteomic databases

PRIDEiQ8CQ56.

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0375.

Structurei

3D structure databases

ProteinModelPortaliQ8CQ56.
SMRiQ8CQ56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DQ4. Bacteria.
COG1064. LUCA.
KOiK13953.
OMAiYKGLKMT.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR029752. D-isomer_DH_CS1.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CQ56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAVVTKDH RVSIEEKRLR ELRPGEALVK TEYCGVCHTD LHVKNADFGD
60 70 80 90 100
VTGVTLGHEG IGRVIKIADN VDSLKVGDRV SIAWMYAACG NCEYCTTGRE
110 120 130 140 150
TLCRDVLNAG YTVDGAMAEE VIVDANYAVK VPENLDPAAA SSITCAGVTT
160 170 180 190 200
YKAVKVSGIE PGQWLGVFGV GGLGNLALQY AKNVMGAKVV AFDINDDKLN
210 220 230 240 250
FAKELGADAI INSTNVDPIE EVNRLTNNKG LDATVITAVA KTPFNQAVDV
260 270 280 290 300
VKAGARVVAV GLPVDKMDLD IPRLVLDGIE VVGSLVGTRQ DLREAFQFAA
310 320 330 340
ENKVIPKIQL RQLSEINDIF DEMEKGTITG RMVIDMKSTH
Length:340
Mass (Da):36,520
Last modified:March 1, 2003 - v1
Checksum:iE95B6D9BE5CD0C3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO03972.1.
RefSeqiNP_763930.1. NC_004461.1.
WP_002438761.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO03972; AAO03972; SE_0375.
GeneIDi1056765.
KEGGisep:SE0375.
PATRICifig|176280.10.peg.350.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH_STAES
AccessioniPrimary (citable) accession number: Q8CQ56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families