Q8CPX1 (AROD_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	SE_0592

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000138814
Sites
	Active site	131	1	Proton acceptor By similarity
	Active site	158	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CPX1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6136644F287387CE	FASTA	238	26,944
	10 20 30 40 50 60 MTHVDIAATI APEDKLSKTL LKDIKVNEES IDIIELRIDQ WPSFNKALLN EVIKQLKIFH 70 80 90 100 110 120 LKILVTYRTS VQGGKGAVNE QEYLNILGEL IECPQFDMID IEWSSAVKIE KYTHLVQRAQ 130 140 150 160 170 180 QKGLEVVLSH HNFQETPALD ELKFIYFKMQ KLNPEYLKLA VMPKCQEDVL HLLEAMSLTA 190 200 210 220 230 KHTTCRIVGI SMSSLGKVSR IAQGVFGGTL SYGCIEEPQA PGQIHVSKLK SMVSFYED

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04189.1.
RefSeq	NP_764147.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CPX1.
SMR	Q8CPX1. Positions 3-236.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CPX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000039618; EBSTAP00000038251; EBSTAG00000039616.
GeneID	1057813.
GenomeReviews	Gene locus SE_0592 in contig AE015929_GR.
KEGG	sep:SE0592.
PATRIC	19606973. VBIStaEpi113981_0564.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
GeneTree	EBGT00050000025297.
HOGENOM	HBG732926.
OMA	IAKIAVM.
PhylomeDB	Q8CPX1.
ProtClustDB	PRK13575.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0592-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STAES

Accession

Primary (citable) accession number: Q8CPX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program