Reviewed, UniProtKB/Swiss-Prot Q8CPT4 (FABH1_STAES)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1
    EC=2.3.1.180
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase III protein 1
    Beta-ketoacyl-ACP synthase III 1
      Short name=KAS III 1

Gene names

Name:	fabH1
Ordered Locus Names:	SE_0677

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity.
Catalytic activity	Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Domain	The last Arg residue of the ACP-binding site is essential for the weak association between ACP/acpP and fabH By similarity.
Sequence similarities	Belongs to the fabH family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP beta-ketoacyl-acyl-carrier-protein synthase III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1 HAMAP MF_01815		PRO_0000110474
Regions
	Region	239 – 243	5	ACP-binding By similarity
Sites
	Active site	112	1	By similarity
	Active site	238	1	By similarity
	Active site	268	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CPT4-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: FC14622D543088BA	FASTA	313	33,982
	10 20 30 40 50 60 MNVGIKGFGA YAPKNIIDNA YFEQFLETSD EWISKMTGIK ERHWADEDQD TSDLAYNASI 70 80 90 100 110 120 KAIEDAGIQP VDIDMIIVAT ATGDMPFPSV ANILQERLGT GKVATMDQLA ACSGFMYSMI 130 140 150 160 170 180 TAKQYIQSGD YKHILVVGAD KLSKITDMTD RSTAVLFGDG AGAVVMGEVA EGRGIISYEM 190 200 210 220 230 240 GSDGSGGKYL YLDRETGKLK MNGREVFKFA VRIMGDASTR VVEKAGLSSE DIDLFVPHQA 250 260 270 280 290 300 NIRIMESARE RLGIEREKMS VSVNKYGNTS AASIPLSINQ ELQNGKIKDD DTLVLVGFGG 310 GLTWGAIVIK WGK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015929 Genomic DNA. Translation: AAO04274.1.
RefSeq	NP_764232.1.
3D structure databases
HSSP	HSSP built from PDB template 1HNK based on UniProtKB P24249.
SMR	Q8CPT4. Positions 1-312.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CPT4.
Genome annotation databases
GeneID	1057918.
GenomeReviews	Gene locus SE_0677 in contig AE015929_GR.
KEGG	sep:SE0677.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8CPT4.
OMA	YIVPHQA.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0677-MON.
Family and domain databases
HAMAP	MF_01815. [Tree]
InterPro	IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. [Graphical view]
Pfam	PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00747. fabH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABH1_STAES

Accession

Primary (citable) accession number: Q8CPT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)