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Q8CPN3

- ODPA_STAES

UniProt

Q8CPN3 - ODPA_STAES

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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-796-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:SE_0791
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162211Add
BLAST

Proteomic databases

PRIDEiQ8CPN3.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi176280.SE0791.

Structurei

3D structure databases

ProteinModelPortaliQ8CPN3.
SMRiQ8CPN3. Positions 8-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
KOiK00161.
OMAiNNGYAIT.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CPN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPKLQAQFD AVKVLNETQS KFEMVQILDE DGNVVNEDLV PDLTDEQLVE
60 70 80 90 100
LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALESEDFI
110 120 130 140 150
LPGYRDVPQI IWHGLPLTDA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY
160 170 180 190 200
IQTAGVAFGL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA SAYKAPAIFV
210 220 230 240 250
IQNNNYAIST PRSKQTAAET LAQKAISVGI PGIQVDGMDA LAVYQATLEA
260 270 280 290 300
RERAVAGEGP TVIETLTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR
310 320 330 340 350
FRKYLEAKGL WNEDKENEVV ERAKSEIKAA IKEADNTEKQ TVTSLMDIMY
360 370
EEMPQNLAEQ YEIYKEKESK
Length:370
Mass (Da):41,330
Last modified:March 1, 2003 - v1
Checksum:iF691D1D8C2E3EEB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04388.1.
RefSeqiNP_764346.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04388; AAO04388; SE_0791.
GeneIDi1057335.
KEGGisep:SE0791.
PATRICi19607379. VBIStaEpi113981_0764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04388.1 .
RefSeqi NP_764346.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CPN3.
SMRi Q8CPN3. Positions 8-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE0791.

Proteomic databases

PRIDEi Q8CPN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO04388 ; AAO04388 ; SE_0791 .
GeneIDi 1057335.
KEGGi sep:SE0791.
PATRICi 19607379. VBIStaEpi113981_0764.

Phylogenomic databases

eggNOGi COG1071.
KOi K00161.
OMAi NNGYAIT.
OrthoDBi EOG6VMTKR.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-796-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiODPA_STAES
AccessioniPrimary (citable) accession number: Q8CPN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3