Q8CPI3 (FABG_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG
EC=1.1.1.100

Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase

Gene names

Name:	fabG
Ordered Locus Names:	SE_0906

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	3-oxoacyl-[acyl-carrier-protein] reductase FabG		PRO_0000054689
Regions
	Nucleotide binding	9 – 12	4	NADP By similarity
	Nucleotide binding	60 – 61	2	NADP By similarity
	Nucleotide binding	152 – 156	5	NADP By similarity
Sites
	Active site	152	1	Proton acceptor By similarity
	Binding site	87	1	NADP; via carbonyl oxygen By similarity
	Binding site	139	1	Substrate By similarity
	Binding site	185	1	NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CPI3 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 8F4CEC8E13E5BA09	FASTA	244	26,074
	10 20 30 40 50 60 MNKSALVTGA SRGIGRSIAL QLAEEGYNVA VNYAGSKDKA EAVVEEIKAK GVESFAIQAN 70 80 90 100 110 120 VAKGDEVKEM IKEVVSQFGS VDVLVNNAGI TKDNLLMRMK EQEWDDVIDT NLKGVFNCIQ 130 140 150 160 170 180 KVTPQMLRQR SGAIINLTSI VGAMGNPGQA NYVATKAGVI GLTKTAAREL ASRGITVNAV 190 200 210 220 230 240 APGFIVSDMT NALSDDLKDQ MLEQIPLKRF GEDTDIANTV AFLASDKAKY ITGQTIHVNG GMYM

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04503.1.
RefSeq	NP_764461.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CPI3.
SMR	Q8CPI3. Positions 3-244.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CPI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000039706; EBSTAP00000038339; EBSTAG00000039704.
GeneID	1058018.
GenomeReviews	Gene locus SE_0906 in contig AE015929_GR.
KEGG	sep:SE0906.
PATRIC	19607611. VBIStaEpi113981_0879.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1028.
GeneTree	EBGT00050000023864.
HOGENOM	HBG750976.
OMA	NYAGSEA.
PhylomeDB	Q8CPI3.
ProtClustDB	CLSK885220.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0906-MONOMER.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00059.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_STAES

Accession

Primary (citable) accession number: Q8CPI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program