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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-933-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:SE_0927
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001172651 – 435Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST435

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0927

Structurei

3D structure databases

ProteinModelPortaliQ8CPH2
SMRiQ8CPH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
KOiK04094
OMAiRFGPMKP

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
PROSITEiView protein in PROSITE
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CPH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKVNVVGA GLAGSEAAYQ LAQRGIKVNL IEMRPVKQTP AHHTDKFAEL
60 70 80 90 100
VCSNSLRGNA LTNAVGVLKE EMRHLDSLII TSADKARVPA GGALAVDRHD
110 120 130 140 150
FAGYITDTLR NHPNITVLNE EVNHIPEGYT IIATGPLTTE HLAQEIVDIT
160 170 180 190 200
GKDQLYFYDA AAPIIEKDSI NMDKVYLKSR YDKGEAAYLN CPMTEEEFNR
210 220 230 240 250
FYDAVLEAEV APVNEFEKEK YFEGCMPFEV MAERGRKTLL FGPMKPVGLE
260 270 280 290 300
DPKTGKRPYA VVQLRQDDAA GTLYNIVGFQ THLKWGAQKE VIRLIPGLEN
310 320 330 340 350
VDIVRYGVMH RNTFINSPDV LNEKYELKGH DNLYFAGQMT GVEGYVESAA
360 370 380 390 400
SGLVAGINLA HKILDKGEVI FPRETMIGSM AYYISHAKNE KNFQPMNANF
410 420 430
GLLPSLEKRI KDKKERYETQ AKRALEYLDN YKQTL
Length:435
Mass (Da):48,726
Last modified:March 1, 2003 - v1
Checksum:iBA4E3DA835A8928A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO04524.1
RefSeqiNP_764482.1, NC_004461.1
WP_001832560.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO04524; AAO04524; SE_0927
GeneIDi1057529
KEGGisep:SE0927
PATRICifig|176280.10.peg.902

Similar proteinsi

Entry informationi

Entry nameiTRMFO_STAES
AccessioniPrimary (citable) accession number: Q8CPH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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