Reviewed, UniProtKB/Swiss-Prot Q8CPE6 (GLPD_STAES)

Names and origin

Protein names

Recommended name:
    Aerobic glycerol-3-phosphate dehydrogenase
    EC=1.1.5.3

Gene names

Name:	glpD
Ordered Locus Names:	SE_0979

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor	FAD By similarity.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	glycerol-3-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Aerobic glycerol-3-phosphate dehydrogenase		PRO_0000270066
Regions
	Nucleotide binding	21 – 49	29	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CPE6-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6F6044C656324F7C	FASTA	557	62,276
	10 20 30 40 50 60 MSLSTLKRDH IKKNLRDTEY DVVIVGGGIT GAGIALDASN RGMKVALVEM QDFAQGTSSR 70 80 90 100 110 120 STKLVHGGLR YLKQLQVGVV AETGKERAIV YENGPHVTTP EWMLLPMHKG GTFGKFSTSI 130 140 150 160 170 180 GLAMYDRLAG VKKSERKKML SKQETLNKEP LVKRDGLKGG GYYVEYRTDD ARLTIEVMKK 190 200 210 220 230 240 AAENGAEILN YTKSEHFTYD SNKKVNGIEV LDMIDGETYA IKAKKVINAS GPWVDEVRSG 250 260 270 280 290 300 DYARNNKQLR LTKGVHVVID QSKFPLGQAV YFDTEKDGRM IFAIPREGKA YVGTTDTFYD 310 320 330 340 350 360 NEKATPLTTQ EDRDYLINAI NYMFPTVNVK DEDIESTWAG IRPLILEKGK DPSEISRKDE 370 380 390 400 410 420 VWEGESGLLT IAGGKLTGYR HMALEIVDLL AKRLKQEYGL KFESCATKNL KISGGDVGGS 430 440 450 460 470 480 KNFEHFVEQK VDAAKGFGID EDVARRLASK YGSNVDQLFN IAQTAPYHDS KLPLEIYVEL 490 500 510 520 530 540 VYSIQQEMVY KPTDFLVRRS GKLYFNIQDV LDYKNAVIDV MADMLNYSET QKEAYTEEVE 550 VAIDEARTGN DQPATKA

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015929 Genomic DNA. Translation: AAO04576.1.
RefSeq	NP_764534.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1057632.
GenomeReviews	Gene locus SE_0979 in contig AE015929_GR.
KEGG	sep:SE0979.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8CPE6.
OMA	Q8CPE6. DSIRKMD.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_0979-MON.
Family and domain databases
InterPro	IPR000447. FAD-dep_Gly3P_DH. IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR01001. FADG3PDH.
PROSITE	PS00977. FAD_G3PDH_1. 1 hit. PS00978. FAD_G3PDH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPD_STAES

Accession

Primary (citable) accession number: Q8CPE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)