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Q8CPD0

- CATA_STAES

UniProt

Q8CPD0 - CATA_STAES

Protein

Catalase

Gene

katA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.By similarity

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561PROSITE-ProRule annotation
    Active sitei129 – 1291PROSITE-ProRule annotation
    Metal bindingi339 – 3391Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. catalase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-1022-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catalase (EC:1.11.1.6)
    Gene namesi
    Name:katA
    Ordered Locus Names:SE_1016
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504CatalasePRO_0000085005Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi176280.SE1016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CPD0.
    SMRiQ8CPD0. Positions 7-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.Curated

    Phylogenomic databases

    eggNOGiCOG0753.
    KOiK03781.
    OMAiNCIARFS.
    OrthoDBiEOG6P5Z9F.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CPD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQDGKLTG LFGAPVSDRE NSMTAGQRGP LLMQDVYYLE QISHFDREVI    50
    PERRMHAKGS GAFGTFTVTN DITQYTNAKI FSEVGKQTEM FARFSTVSGE 100
    RGAADLERDI RGFALKFYTE DGNWDLVGNN TPVFFFRDPK LFISLNRAVK 150
    RDPRTNMRSA QNNWDFWTGL PEALHQVTIL MSDRGMPKGF RNMHGFGSHT 200
    YSMYNDKGER VWVKYHFRTQ QGIENYTDEE AAKIVGMDRD SSQRDLYNAI 250
    ENGDYPKWKM YIQVMTEEQA KNHPDNPFDL TKVWYKKDYP LIEVGEFELN 300
    RNPENYFLDV EQAAFTPTNI VPGLDYSPDK MLQGRLFSYG DAQRYRLGVN 350
    HWQIPVNQPK GVGVENLCPF SRDGQMRFLD NNQGGGPHYY PNNQGIYESQ 400
    PEHKKPPFPT DGDGYEYNYR QDDDNYFEQP GKLFRLQSED AKERIFTNTA 450
    NAMDGVSKDV KVRHIRHCYK ADPEYGKGVA KALGIDINQI DLETNQDETY 500
    ENFK 504
    Length:504
    Mass (Da):58,213
    Last modified:March 1, 2003 - v1
    Checksum:i10A1D718AF5A6DBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO04613.1.
    RefSeqiNP_764571.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO04613; AAO04613; SE_1016.
    GeneIDi1056574.
    KEGGisep:SE1016.
    PATRICi19607836. VBIStaEpi113981_0991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO04613.1 .
    RefSeqi NP_764571.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CPD0.
    SMRi Q8CPD0. Positions 7-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE1016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO04613 ; AAO04613 ; SE_1016 .
    GeneIDi 1056574.
    KEGGi sep:SE1016.
    PATRICi 19607836. VBIStaEpi113981_0991.

    Phylogenomic databases

    eggNOGi COG0753.
    KOi K03781.
    OMAi NCIARFS.
    OrthoDBi EOG6P5Z9F.

    Enzyme and pathway databases

    BioCyci SEPI176280:GCDG-1022-MONOMER.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiCATA_STAES
    AccessioniPrimary (citable) accession number: Q8CPD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3