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Q8CPD0 (CATA_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catalase

EC=1.11.1.6
Gene names
Name:katA
Ordered Locus Names:SE_1016
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide By similarity.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the catalase family.

Ontologies

Keywords
   Biological processHydrogen peroxide
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncatalase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Catalase
PRO_0000085005

Sites

Active site561 By similarity
Active site1291 By similarity
Metal binding3391Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CPD0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 10A1D718AF5A6DBD

FASTA50458,213
        10         20         30         40         50         60 
MSKQDGKLTG LFGAPVSDRE NSMTAGQRGP LLMQDVYYLE QISHFDREVI PERRMHAKGS 

        70         80         90        100        110        120 
GAFGTFTVTN DITQYTNAKI FSEVGKQTEM FARFSTVSGE RGAADLERDI RGFALKFYTE 

       130        140        150        160        170        180 
DGNWDLVGNN TPVFFFRDPK LFISLNRAVK RDPRTNMRSA QNNWDFWTGL PEALHQVTIL 

       190        200        210        220        230        240 
MSDRGMPKGF RNMHGFGSHT YSMYNDKGER VWVKYHFRTQ QGIENYTDEE AAKIVGMDRD 

       250        260        270        280        290        300 
SSQRDLYNAI ENGDYPKWKM YIQVMTEEQA KNHPDNPFDL TKVWYKKDYP LIEVGEFELN 

       310        320        330        340        350        360 
RNPENYFLDV EQAAFTPTNI VPGLDYSPDK MLQGRLFSYG DAQRYRLGVN HWQIPVNQPK 

       370        380        390        400        410        420 
GVGVENLCPF SRDGQMRFLD NNQGGGPHYY PNNQGIYESQ PEHKKPPFPT DGDGYEYNYR 

       430        440        450        460        470        480 
QDDDNYFEQP GKLFRLQSED AKERIFTNTA NAMDGVSKDV KVRHIRHCYK ADPEYGKGVA 

       490        500 
KALGIDINQI DLETNQDETY ENFK 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015929 Genomic DNA. Translation: AAO04613.1.
RefSeqNP_764571.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CPD0.
SMRQ8CPD0. Positions 7-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE1016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO04613; AAO04613; SE_1016.
GeneID1056574.
KEGGsep:SE1016.
PATRIC19607836. VBIStaEpi113981_0991.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0753.
KOK03781.
OMANCIARFS.
OrthoDBEOG6P5Z9F.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-1022-MONOMER.

Family and domain databases

Gene3D2.40.180.10. 1 hit.
InterProIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERPTHR11465. PTHR11465. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSPR00067. CATALASE.
SMARTSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMSSF56634. SSF56634. 1 hit.
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATA_STAES
AccessionPrimary (citable) accession number: Q8CPD0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families