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Q8CPD0

- CATA_STAES

UniProt

Q8CPD0 - CATA_STAES

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Protein

Catalase

Gene

katA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.By similarity

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561PROSITE-ProRule annotation
Active sitei129 – 1291PROSITE-ProRule annotation
Metal bindingi339 – 3391Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1022-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:katA
Ordered Locus Names:SE_1016
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504CatalasePRO_0000085005Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi176280.SE1016.

Structurei

3D structure databases

ProteinModelPortaliQ8CPD0.
SMRiQ8CPD0. Positions 7-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiCOG0753.
KOiK03781.
OMAiNCIARFS.
OrthoDBiEOG6P5Z9F.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CPD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQDGKLTG LFGAPVSDRE NSMTAGQRGP LLMQDVYYLE QISHFDREVI
60 70 80 90 100
PERRMHAKGS GAFGTFTVTN DITQYTNAKI FSEVGKQTEM FARFSTVSGE
110 120 130 140 150
RGAADLERDI RGFALKFYTE DGNWDLVGNN TPVFFFRDPK LFISLNRAVK
160 170 180 190 200
RDPRTNMRSA QNNWDFWTGL PEALHQVTIL MSDRGMPKGF RNMHGFGSHT
210 220 230 240 250
YSMYNDKGER VWVKYHFRTQ QGIENYTDEE AAKIVGMDRD SSQRDLYNAI
260 270 280 290 300
ENGDYPKWKM YIQVMTEEQA KNHPDNPFDL TKVWYKKDYP LIEVGEFELN
310 320 330 340 350
RNPENYFLDV EQAAFTPTNI VPGLDYSPDK MLQGRLFSYG DAQRYRLGVN
360 370 380 390 400
HWQIPVNQPK GVGVENLCPF SRDGQMRFLD NNQGGGPHYY PNNQGIYESQ
410 420 430 440 450
PEHKKPPFPT DGDGYEYNYR QDDDNYFEQP GKLFRLQSED AKERIFTNTA
460 470 480 490 500
NAMDGVSKDV KVRHIRHCYK ADPEYGKGVA KALGIDINQI DLETNQDETY

ENFK
Length:504
Mass (Da):58,213
Last modified:March 1, 2003 - v1
Checksum:i10A1D718AF5A6DBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04613.1.
RefSeqiNP_764571.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04613; AAO04613; SE_1016.
GeneIDi1056574.
KEGGisep:SE1016.
PATRICi19607836. VBIStaEpi113981_0991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO04613.1 .
RefSeqi NP_764571.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CPD0.
SMRi Q8CPD0. Positions 7-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO04613 ; AAO04613 ; SE_1016 .
GeneIDi 1056574.
KEGGi sep:SE1016.
PATRICi 19607836. VBIStaEpi113981_0991.

Phylogenomic databases

eggNOGi COG0753.
KOi K03781.
OMAi NCIARFS.
OrthoDBi EOG6P5Z9F.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-1022-MONOMER.

Family and domain databases

Gene3Di 2.40.180.10. 1 hit.
InterProi IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view ]
PANTHERi PTHR11465. PTHR11465. 1 hit.
Pfami PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view ]
PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSi PR00067. CATALASE.
SMARTi SM01060. Catalase. 1 hit.
[Graphical view ]
SUPFAMi SSF56634. SSF56634. 1 hit.
PROSITEi PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiCATA_STAES
AccessioniPrimary (citable) accession number: Q8CPD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3