Q8CPC4 (MSCL_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	SE_1030

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000192467
Regions
	Topological domain	1 – 16	16	Cytoplasmic Potential
	Transmembrane	17 – 39	23	Helical; Potential
	Topological domain	40 – 64	25	Extracellular Potential
	Transmembrane	65 – 84	20	Helical; Potential
	Topological domain	85 – 116	32	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CPC4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1C3DA2304B9D5993	FASTA	116	13,254
	10 20 30 40 50 60 MLKEFKEFAL KGNVLDLAIA VVMGAAFNKI VTSLVQYIIM PLIGKLFGSV NFAEDWSFWG 70 80 90 100 110 IKYGLFIQSI IDFIIIAFAL FIFVKIANTV MKKEEKEEEV EENTVLLTEI RDLLKK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04627.1.
RefSeq	NP_764585.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CPC4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CPC4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000040295; EBSTAP00000038928; EBSTAG00000040293.
GeneID	1056568.
GenomeReviews	Gene locus SE_1030 in contig AE015929_GR.
KEGG	sep:SE1030.
PATRIC	19607864. VBIStaEpi113981_1005.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
GeneTree	EBGT00050000025511.
HOGENOM	HBG727604.
OMA	LMVRAIT.
PhylomeDB	Q8CPC4.
ProtClustDB	PRK13954.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_1030-MONOMER.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_STAES

Accession

Primary (citable) accession number: Q8CPC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program