ID   TYRA_STAES              Reviewed;         362 AA.
AC   Q8CPB5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Prephenate dehydrogenase;
DE            Short=PDH;
DE            EC=1.3.1.12;
GN   Name=tyrA; OrderedLocusNames=SE_1047;
OS   Staphylococcus epidermidis (strain ATCC 12228).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22832016; PubMed=12950922;
RX   DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J.,
RA   Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z.,
RA   Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- CATALYTIC ACTIVITY: Prephenate + NAD(+) = 4-hydroxyphenylpyruvate
CC       + CO(2) + NADH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; L-
CC       tyrosine from prephenate: step 1/2.
CC   -!- SIMILARITY: Contains 1 ACT domain.
CC   -!- SIMILARITY: Contains 1 prephenate/arogenate dehydrogenase domain.
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DR   EMBL; AE015929; AAO04644.1; -; Genomic_DNA.
DR   RefSeq; NP_764602.1; -.
DR   GeneID; 1056563; -.
DR   GenomeReviews; AE015929_GR; SE_1047.
DR   KEGG; sep:SE1047; -.
DR   HOGENOM; Q8CPB5; -.
DR   OMA; Q8CPB5; QRAIRWG.
DR   BioCyc; SEPI176280:SE_1047-MON; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; Prephen_DH; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF02153; PDH; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NAD; Oxidoreductase; Tyrosine biosynthesis.
FT   CHAIN         1    362       Prephenate dehydrogenase.
FT                                /FTId=PRO_0000282663.
FT   DOMAIN        2    291       Prephenate/arogenate dehydrogenase.
FT   DOMAIN      295    355       ACT.
FT   NP_BIND       3     33       NAD (Potential).
SQ   SEQUENCE   362 AA;  40710 MW;  BB0D1A12046E0A3B CRC64;
     MRNILFVGLG LIGGSLASNL KYHYSNFNIL AYDSDYTQLD EALSIGIIDQ KVNDYATAVE
     IADIIIFATP VEQTIKYLSE LTNYNTKTHL IVTDTGSTKL TIQSFEKELL KHDIHLISGH
     PMAGSHKSGV LNAKKHLFEN AYYILVFNEI ENNEAATYLK KLLKPTLAKF IVTHANEHDF
     VTGIVSHVPH IIASILVHLS ANHVKDHSLI EKLAAGGFRD ITRIASSNAQ MWKDITLNNQ
     NHILSLLNEI KEQITGIENL IREQNSNSIY DFFVKAKDYR DQLPVKQHGA ISTAYDLYVD
     IPDKPGMISQ ITNIISSHNI SIINLKILEV REDIYGALQI SFKSPEDREN AIKALANFDT
     YY
//