Q8CPB5 (TYRA_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prephenate dehydrogenase
Short name=PDH
EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	SE_1047

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Prephenate dehydrogenase		PRO_0000282663
Regions
	Domain	2 – 291	290	Prephenate/arogenate dehydrogenase
	Domain	295 – 355	61	ACT
	Nucleotide binding	3 – 33	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CPB5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: BB0D1A12046E0A3B	FASTA	362	40,710
	10 20 30 40 50 60 MRNILFVGLG LIGGSLASNL KYHYSNFNIL AYDSDYTQLD EALSIGIIDQ KVNDYATAVE 70 80 90 100 110 120 IADIIIFATP VEQTIKYLSE LTNYNTKTHL IVTDTGSTKL TIQSFEKELL KHDIHLISGH 130 140 150 160 170 180 PMAGSHKSGV LNAKKHLFEN AYYILVFNEI ENNEAATYLK KLLKPTLAKF IVTHANEHDF 190 200 210 220 230 240 VTGIVSHVPH IIASILVHLS ANHVKDHSLI EKLAAGGFRD ITRIASSNAQ MWKDITLNNQ 250 260 270 280 290 300 NHILSLLNEI KEQITGIENL IREQNSNSIY DFFVKAKDYR DQLPVKQHGA ISTAYDLYVD 310 320 330 340 350 360 IPDKPGMISQ ITNIISSHNI SIINLKILEV REDIYGALQI SFKSPEDREN AIKALANFDT YY

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04644.1.
RefSeq	NP_764602.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CPB5.
ModBase	Search...
Protein-protein interaction databases
STRING	176280.SE1047.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO04644; AAO04644; SE_1047.
GeneID	1056563.
KEGG	sep:SE1047.
PATRIC	19607900. VBIStaEpi113981_1023.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0287.
KO	K04517.
OMA	QRAIRWG.
ProtClustDB	PRK06545.
Enzyme and pathway databases
UniPathway	UPA00122; UER00961.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR002912. ACT_dom. IPR016040. NAD(P)-bd_dom. IPR003099. Prephen_DH. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF02153. PDH. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_STAES

Accession

Primary (citable) accession number: Q8CPB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program