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Q8CPB5

- TYRA_STAES

UniProt

Q8CPB5 - TYRA_STAES

Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi3 – 3331NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tyrosine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-1053-MONOMER.
    UniPathwayiUPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrA
    Ordered Locus Names:SE_1047
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Prephenate dehydrogenasePRO_0000282663Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE1047.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CPB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 291290Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST
    Domaini296 – 36267ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0287.
    KOiK04517.
    OMAiHAMAGTH.
    OrthoDBiEOG6B8XMB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CPB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNILFVGLG LIGGSLASNL KYHYSNFNIL AYDSDYTQLD EALSIGIIDQ    50
    KVNDYATAVE IADIIIFATP VEQTIKYLSE LTNYNTKTHL IVTDTGSTKL 100
    TIQSFEKELL KHDIHLISGH PMAGSHKSGV LNAKKHLFEN AYYILVFNEI 150
    ENNEAATYLK KLLKPTLAKF IVTHANEHDF VTGIVSHVPH IIASILVHLS 200
    ANHVKDHSLI EKLAAGGFRD ITRIASSNAQ MWKDITLNNQ NHILSLLNEI 250
    KEQITGIENL IREQNSNSIY DFFVKAKDYR DQLPVKQHGA ISTAYDLYVD 300
    IPDKPGMISQ ITNIISSHNI SIINLKILEV REDIYGALQI SFKSPEDREN 350
    AIKALANFDT YY 362
    Length:362
    Mass (Da):40,710
    Last modified:March 1, 2003 - v1
    Checksum:iBB0D1A12046E0A3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO04644.1.
    RefSeqiNP_764602.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO04644; AAO04644; SE_1047.
    GeneIDi1056563.
    KEGGisep:SE1047.
    PATRICi19607900. VBIStaEpi113981_1023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO04644.1 .
    RefSeqi NP_764602.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CPB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE1047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO04644 ; AAO04644 ; SE_1047 .
    GeneIDi 1056563.
    KEGGi sep:SE1047.
    PATRICi 19607900. VBIStaEpi113981_1023.

    Phylogenomic databases

    eggNOGi COG0287.
    KOi K04517.
    OMAi HAMAGTH.
    OrthoDBi EOG6B8XMB.

    Enzyme and pathway databases

    UniPathwayi UPA00122 ; UER00961 .
    BioCyci SEPI176280:GCDG-1053-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiTYRA_STAES
    AccessioniPrimary (citable) accession number: Q8CPB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3