Q8CP83 (ODO1_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component
EC=1.2.4.2

Alternative name(s):
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	SE_1097

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	934 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169
Cofactor	Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01169
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamine pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 934	934	2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169		PRO_0000162183

Sequences

	Sequence		Length	Mass (Da)
	Q8CP83 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DD892FD718D6C28A	FASTA	934	105,693
	10 20 30 40 50 60 MTKNKKEFTE APVNFGANLG LMLDLYDDYL QDPSSVPEDL QVLFSTIKTG EAHIEAKPTT 70 80 90 100 110 120 DGGGSQAGDS TIKRVMRLID NIRQYGHLKA DIYPVNPPER QNVPKLEIED FDLDKETLEK 130 140 150 160 170 180 ISSGIVSEHF KDIYDNAYDA IVRMERRYKG PIAFEYTHIN NNKERVWLKR RIETPYKASL 190 200 210 220 230 240 NDNQKKELFK KLAHVEGFEK YLHKNFVGAK RFSIEGVDTL VPMLQHTITL AGNEGIKNIQ 250 260 270 280 290 300 IGMAHRGRLN VLTHVLEKPY EMMISEFMHT DPMKFLPEDG SLELTSGWTS DVKYHLGGVK 310 320 330 340 350 360 TTNSYGIEQR ISLANNPSHL EIVAPVVAGK TRAAQDNTHQ VGAPSTDFHK AMPIIIHGDA 370 380 390 400 410 420 AYPGQGINFE TMNLGSLKGY STGGSLHIIT NNRIGFTTEP IDGRSTTYSS DVAKGYDVPI 430 440 450 460 470 480 LHVNADDVEA TIEAIEIAME FRKEFHKDVV IDLVGYRRYG HNEMDEPSIT NPVPYQNIRK 490 500 510 520 530 540 HDSVEILYGK KLVDEGIISE DEMNEVIDGV QKEMRTAHDK IDKNDKMNNP DMEKPESLQL 550 560 570 580 590 600 PLQSDTKDFS FDHLKEINDA MLDYPKDFHV LKKLNKVLEK RREPFEKEEG LVDWAQAEQL 610 620 630 640 650 660 AFATILQDGT SIRLTGQDSE RGTFSHRHAV LHDEENGNTF TPLHHVPQQQ ATFDIHNSPL 670 680 690 700 710 720 SEAAVVGFEY GYNVENKGNF NIWEAQYGDF SNMSQMMFDN FLSSSRAKWG ERSGLTLFLP 730 740 750 760 770 780 HAFEGQGPEH SSARLERFLQ LAAENNSTVV NLSSASNYFH LLRAQAASLD TLEMRPLIVM 790 800 810 820 830 840 SPKSLLRNKT VAKPIDEFTS GGFKPIITED IDEQKVKKVI LASGKMYIDL KEYLAKNPND 850 860 870 880 890 900 SILLIAVERL YPFPEEEIKE VLKSLPHLEN VSWVQEEPKN QGAWLFVYPY LKALVANKYD 910 920 930 LTYHGRIQRA APAEGDGEIH KLVQTKIIES SINN

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04694.1.
RefSeq	NP_764652.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CP83.
ModBase	Search...
Protein-protein interaction databases
STRING	176280.SE1097.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO04694; AAO04694; SE_1097.
GeneID	1057037.
KEGG	sep:SE1097.
PATRIC	19608000. VBIStaEpi113981_1073.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
KO	K00164.
OMA	QEVQKYP.
ProtClustDB	PRK09404.
Enzyme and pathway databases
BioCyc	SEPI176280:GCDG-1103-MONOMER.
Family and domain databases
HAMAP	MF_01169. SucA_OdhA.
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR023784. 2oxoglutarate_DH_E1_bac. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_STAES

Accession

Primary (citable) accession number: Q8CP83

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program