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Q8CP83

- ODO1_STAES

UniProt

Q8CP83 - ODO1_STAES

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:SE_1097
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9349342-oxoglutarate dehydrogenase E1 componentPRO_0000162183Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176280.SE1097.

Structurei

3D structure databases

ProteinModelPortaliQ8CP83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiQHAPNKE.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CP83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKNKKEFTE APVNFGANLG LMLDLYDDYL QDPSSVPEDL QVLFSTIKTG
60 70 80 90 100
EAHIEAKPTT DGGGSQAGDS TIKRVMRLID NIRQYGHLKA DIYPVNPPER
110 120 130 140 150
QNVPKLEIED FDLDKETLEK ISSGIVSEHF KDIYDNAYDA IVRMERRYKG
160 170 180 190 200
PIAFEYTHIN NNKERVWLKR RIETPYKASL NDNQKKELFK KLAHVEGFEK
210 220 230 240 250
YLHKNFVGAK RFSIEGVDTL VPMLQHTITL AGNEGIKNIQ IGMAHRGRLN
260 270 280 290 300
VLTHVLEKPY EMMISEFMHT DPMKFLPEDG SLELTSGWTS DVKYHLGGVK
310 320 330 340 350
TTNSYGIEQR ISLANNPSHL EIVAPVVAGK TRAAQDNTHQ VGAPSTDFHK
360 370 380 390 400
AMPIIIHGDA AYPGQGINFE TMNLGSLKGY STGGSLHIIT NNRIGFTTEP
410 420 430 440 450
IDGRSTTYSS DVAKGYDVPI LHVNADDVEA TIEAIEIAME FRKEFHKDVV
460 470 480 490 500
IDLVGYRRYG HNEMDEPSIT NPVPYQNIRK HDSVEILYGK KLVDEGIISE
510 520 530 540 550
DEMNEVIDGV QKEMRTAHDK IDKNDKMNNP DMEKPESLQL PLQSDTKDFS
560 570 580 590 600
FDHLKEINDA MLDYPKDFHV LKKLNKVLEK RREPFEKEEG LVDWAQAEQL
610 620 630 640 650
AFATILQDGT SIRLTGQDSE RGTFSHRHAV LHDEENGNTF TPLHHVPQQQ
660 670 680 690 700
ATFDIHNSPL SEAAVVGFEY GYNVENKGNF NIWEAQYGDF SNMSQMMFDN
710 720 730 740 750
FLSSSRAKWG ERSGLTLFLP HAFEGQGPEH SSARLERFLQ LAAENNSTVV
760 770 780 790 800
NLSSASNYFH LLRAQAASLD TLEMRPLIVM SPKSLLRNKT VAKPIDEFTS
810 820 830 840 850
GGFKPIITED IDEQKVKKVI LASGKMYIDL KEYLAKNPND SILLIAVERL
860 870 880 890 900
YPFPEEEIKE VLKSLPHLEN VSWVQEEPKN QGAWLFVYPY LKALVANKYD
910 920 930
LTYHGRIQRA APAEGDGEIH KLVQTKIIES SINN
Length:934
Mass (Da):105,693
Last modified:March 1, 2003 - v1
Checksum:iDD892FD718D6C28A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO04694.1.
RefSeqiNP_764652.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04694; AAO04694; SE_1097.
GeneIDi1057037.
KEGGisep:SE1097.
PATRICi19608000. VBIStaEpi113981_1073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO04694.1 .
RefSeqi NP_764652.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CP83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO04694 ; AAO04694 ; SE_1097 .
GeneIDi 1057037.
KEGGi sep:SE1097.
PATRICi 19608000. VBIStaEpi113981_1073.

Phylogenomic databases

eggNOGi COG0567.
KOi K00164.
OMAi QHAPNKE.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-1103-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiODO1_STAES
AccessioniPrimary (citable) accession number: Q8CP83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3