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Q8CP83

- ODO1_STAES

UniProt

Q8CP83 - ODO1_STAES

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, SE_1097
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:SE_1097
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9349342-oxoglutarate dehydrogenase E1 componentUniRule annotation
PRO_0000162183Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi176280.SE1097.

Structurei

3D structure databases

ProteinModelPortaliQ8CP83.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiQHAPNKE.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CP83-1 [UniParc]FASTAAdd to Basket

« Hide

MTKNKKEFTE APVNFGANLG LMLDLYDDYL QDPSSVPEDL QVLFSTIKTG    50
EAHIEAKPTT DGGGSQAGDS TIKRVMRLID NIRQYGHLKA DIYPVNPPER 100
QNVPKLEIED FDLDKETLEK ISSGIVSEHF KDIYDNAYDA IVRMERRYKG 150
PIAFEYTHIN NNKERVWLKR RIETPYKASL NDNQKKELFK KLAHVEGFEK 200
YLHKNFVGAK RFSIEGVDTL VPMLQHTITL AGNEGIKNIQ IGMAHRGRLN 250
VLTHVLEKPY EMMISEFMHT DPMKFLPEDG SLELTSGWTS DVKYHLGGVK 300
TTNSYGIEQR ISLANNPSHL EIVAPVVAGK TRAAQDNTHQ VGAPSTDFHK 350
AMPIIIHGDA AYPGQGINFE TMNLGSLKGY STGGSLHIIT NNRIGFTTEP 400
IDGRSTTYSS DVAKGYDVPI LHVNADDVEA TIEAIEIAME FRKEFHKDVV 450
IDLVGYRRYG HNEMDEPSIT NPVPYQNIRK HDSVEILYGK KLVDEGIISE 500
DEMNEVIDGV QKEMRTAHDK IDKNDKMNNP DMEKPESLQL PLQSDTKDFS 550
FDHLKEINDA MLDYPKDFHV LKKLNKVLEK RREPFEKEEG LVDWAQAEQL 600
AFATILQDGT SIRLTGQDSE RGTFSHRHAV LHDEENGNTF TPLHHVPQQQ 650
ATFDIHNSPL SEAAVVGFEY GYNVENKGNF NIWEAQYGDF SNMSQMMFDN 700
FLSSSRAKWG ERSGLTLFLP HAFEGQGPEH SSARLERFLQ LAAENNSTVV 750
NLSSASNYFH LLRAQAASLD TLEMRPLIVM SPKSLLRNKT VAKPIDEFTS 800
GGFKPIITED IDEQKVKKVI LASGKMYIDL KEYLAKNPND SILLIAVERL 850
YPFPEEEIKE VLKSLPHLEN VSWVQEEPKN QGAWLFVYPY LKALVANKYD 900
LTYHGRIQRA APAEGDGEIH KLVQTKIIES SINN 934
Length:934
Mass (Da):105,693
Last modified:March 1, 2003 - v1
Checksum:iDD892FD718D6C28A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO04694.1.
RefSeqiNP_764652.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04694; AAO04694; SE_1097.
GeneIDi1057037.
KEGGisep:SE1097.
PATRICi19608000. VBIStaEpi113981_1073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO04694.1 .
RefSeqi NP_764652.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CP83.
ModBasei Search...

Protein-protein interaction databases

STRINGi 176280.SE1097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO04694 ; AAO04694 ; SE_1097 .
GeneIDi 1057037.
KEGGi sep:SE1097.
PATRICi 19608000. VBIStaEpi113981_1073.

Phylogenomic databases

eggNOGi COG0567.
KOi K00164.
OMAi QHAPNKE.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-1103-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiODO1_STAES
AccessioniPrimary (citable) accession number: Q8CP83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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