ID   P5CR_STAES              Reviewed;         271 AA.
AC   Q8CP51;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 38.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC; OrderedLocusNames=SE_1186;
OS   Staphylococcus epidermidis (strain ATCC 12228).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22832016; PubMed=12950922;
RX   DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J.,
RA   Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z.,
RA   Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; AE015929; AAO04785.1; -; Genomic_DNA.
DR   RefSeq; NP_764741.1; -.
DR   GeneID; 1056002; -.
DR   GenomeReviews; AE015929_GR; SE_1186.
DR   KEGG; sep:SE1186; -.
DR   HOGENOM; Q8CP51; -.
DR   OMA; Q8CP51; AMPNTSA.
DR   BioCyc; SEPI176280:SE_1186-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP;
KW   Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    271       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187304.
SQ   SEQUENCE   271 AA;  30111 MW;  DBFFEDA2289255D7 CRC64;
     MKLVFYGAGN MAQAIFTGII NSNNLNANDI YLTNKSNEQA LKSFAEKLGV NYSYDDEALL
     KDADYVFLGT KPHDFENLAN RIREHITNDN RFISIMAGLS IDYIRQQLNT NNPLARIMPN
     TNAQVGHSVT GISFSNNFDP KSKNEVDELI NAFGSVIEVS EEHLHQVTAI TGSGPAFLYH
     VFEQYVKAGT ELGLERNQVE ESIRNLIIGT SKMIERSDLS MSQLRKNITS KGGTTQAGLD
     ALSQYDIVSM FEDCLGAAVN RSMELSHKED E
//