Q8CP51 (P5CR_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	SE_1186

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Pyrroline-5-carboxylate reductase		PRO_0000187304

Sequences

	Sequence		Length	Mass (Da)
	Q8CP51 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DBFFEDA2289255D7	FASTA	271	30,111
	10 20 30 40 50 60 MKLVFYGAGN MAQAIFTGII NSNNLNANDI YLTNKSNEQA LKSFAEKLGV NYSYDDEALL 70 80 90 100 110 120 KDADYVFLGT KPHDFENLAN RIREHITNDN RFISIMAGLS IDYIRQQLNT NNPLARIMPN 130 140 150 160 170 180 TNAQVGHSVT GISFSNNFDP KSKNEVDELI NAFGSVIEVS EEHLHQVTAI TGSGPAFLYH 190 200 210 220 230 240 VFEQYVKAGT ELGLERNQVE ESIRNLIIGT SKMIERSDLS MSQLRKNITS KGGTTQAGLD 250 260 270 ALSQYDIVSM FEDCLGAAVN RSMELSHKED E

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO04785.1.
RefSeq	NP_764741.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CP51.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CP51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000039110; EBSTAP00000037743; EBSTAG00000039108.
GeneID	1056002.
GenomeReviews	Gene locus SE_1186 in contig AE015929_GR.
KEGG	sep:SE1186.
PATRIC	19608168. VBIStaEpi113981_1157.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0345.
GeneTree	EBGT00050000024862.
HOGENOM	HBG726602.
OMA	HKKYGVK.
PhylomeDB	Q8CP51.
ProtClustDB	CLSK885395.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_1186-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

P5CR_STAES

Accession

Primary (citable) accession number: Q8CP51

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program