Reviewed, UniProtKB/Swiss-Prot Q8CP51 (P5CR_STAES)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	SE_1186

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Pyrroline-5-carboxylate reductase		PRO_0000187304

Sequences

	Sequence		Length	Mass (Da)
	Q8CP51-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DBFFEDA2289255D7	FASTA	271	30,111
	10 20 30 40 50 60 MKLVFYGAGN MAQAIFTGII NSNNLNANDI YLTNKSNEQA LKSFAEKLGV NYSYDDEALL 70 80 90 100 110 120 KDADYVFLGT KPHDFENLAN RIREHITNDN RFISIMAGLS IDYIRQQLNT NNPLARIMPN 130 140 150 160 170 180 TNAQVGHSVT GISFSNNFDP KSKNEVDELI NAFGSVIEVS EEHLHQVTAI TGSGPAFLYH 190 200 210 220 230 240 VFEQYVKAGT ELGLERNQVE ESIRNLIIGT SKMIERSDLS MSQLRKNITS KGGTTQAGLD 250 260 270 ALSQYDIVSM FEDCLGAAVN RSMELSHKED E

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015929 Genomic DNA. Translation: AAO04785.1.
RefSeq	NP_764741.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1056002.
GenomeReviews	Gene locus SE_1186 in contig AE015929_GR.
KEGG	sep:SE1186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8CP51.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_1186-MON.
Family and domain databases
InterPro	IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

P5CR_STAES

Accession

Primary (citable) accession number: Q8CP51

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	March 1, 2003
Last modified:	November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)