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Q8CP09 (AROE_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:SE_1282
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

shikimate 3-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Shikimate dehydrogenase HAMAP MF_00222
PRO_0000136036

Regions

Nucleotide binding127 – 1315NADP By similarity

Sites

Active site671Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
Q8CP09 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: BF14A9E200208E90

FASTA27230,288
        10         20         30         40         50         60 
MIKVKFAVIG NPISHSLSPL MHHANFQSLN LENTYEAINV PVNQFQDIKK IISEKSIDGF 

        70         80         90        100        110        120 
NVTIPHKERI IPYLDDINEQ AKSVGAVNTV LVKDGKWIGY NTDGIGYVNG LKQIYEGIED 

       130        140        150        160        170        180 
AYILILGAGG ASKGIANELY KIVRPTLTVA NRTMSRFNNW SLNINKINLS HAESHLDEFD 

       190        200        210        220        230        240 
IIINTTPAGM NGNTDSVISL NRLASHTLVS DIVYNPYKTP ILIEAEQRGN PIYNGLDMFV 

       250        260        270 
HQGAESFKIW TNLEPDIKAM KNIVIQKLKG EL

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References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO04881.1.
RefSeqNP_764837.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CP09.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CP09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000039071; EBSTAP00000037704; EBSTAG00000039069.
GeneID1057358.
GenomeReviewsGene locus SE_1282 in contig AE015929_GR.
KEGGsep:SE1282.
PATRIC19608356. VBIStaEpi113981_1251.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0169.
GeneTreeEBGT00050000025479.
HOGENOMHBG553408.
OMAGIANELY.
PhylomeDBQ8CP09.
ProtClustDBCLSK885454.

Enzyme and pathway databases

BioCycSEPI176280:SE_1282-MONOMER.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_STAES
AccessionPrimary (citable) accession number: Q8CP09
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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