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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94NADPBy similarity1
Binding sitei103SubstrateBy similarity1
Binding sitei105SubstrateBy similarity1
Binding sitei109SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei143SubstrateBy similarity1
Sitei150Critical for catalysisBy similarity1
Sitei220Critical for catalysisBy similarity1
Metal bindingi310Magnesium or manganeseBy similarity1
Binding sitei357NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei396NADPBy similarity1
Binding sitei400NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi344 – 350NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-1376-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:citC
Ordered Locus Names:SE_1370
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835651 – 422Isocitrate dehydrogenase [NADP]Add BLAST422

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi176280.SE1370

Structurei

3D structure databases

ProteinModelPortaliQ8CNX4
SMRiQ8CNX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HMX Bacteria
COG0538 LUCA
KOiK00031
OMAiFQQIQTR

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004439 Isocitrate_DH_NADP_dimer_prok
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR43504 PTHR43504, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00183 prok_nadp_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CNX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEKITQSK DGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN
60 70 80 90 100
GEKRIEWKEV LAGQKAYDET GEWLPQETLE TIKEYLIAVK GPLTTPIGGG
110 120 130 140 150
IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPEDVDMV IFRENTEDIY
160 170 180 190 200
AGIEFKQGTS EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLV
210 220 230 240 250
RAAIQYALDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAH NEFGDKVFTW
260 270 280 290 300
QQYDEIVEQK GKDAANEAQS KAEQEGKIII KDSIADIFLQ QILTRPAEHD
310 320 330 340 350
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY
360 370 380 390 400
AGLNKVNPSS EILSSVLMLE HLGWQEAADK ITDSIEATIA SKIVTYDFAR
410 420
LMDGAKEVST SDFADELIKN IR
Length:422
Mass (Da):46,619
Last modified:March 1, 2003 - v1
Checksum:i31EA599CF275A83C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO04969.1
RefSeqiNP_764925.1, NC_004461.1
WP_001830826.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO04969; AAO04969; SE_1370
GeneIDi1058012
KEGGisep:SE1370
PATRICifig|176280.10.peg.1338

Similar proteinsi

Entry informationi

Entry nameiIDH_STAES
AccessioniPrimary (citable) accession number: Q8CNX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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