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Q8CNX4 (IDH_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]
Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
Synonyms:citC
Ordered Locus Names:SE_1370
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Isocitrate dehydrogenase [NADP]
PRO_0000083565

Regions

Nucleotide binding344 – 3507NADP By similarity

Sites

Metal binding3101Magnesium or manganese By similarity
Binding site941NADP By similarity
Binding site1031Substrate By similarity
Binding site1051Substrate By similarity
Binding site1091Substrate By similarity
Binding site1191Substrate By similarity
Binding site1431Substrate By similarity
Binding site3571NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site3961NADP By similarity
Binding site4001NADP By similarity
Site1501Critical for catalysis By similarity
Site2201Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CNX4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 31EA599CF275A83C

FASTA42246,619
        10         20         30         40         50         60 
MSAEKITQSK DGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN GEKRIEWKEV 

        70         80         90        100        110        120 
LAGQKAYDET GEWLPQETLE TIKEYLIAVK GPLTTPIGGG IRSLNVALRQ ELDLFTCLRP 

       130        140        150        160        170        180 
VRWFKGVPSP VKRPEDVDMV IFRENTEDIY AGIEFKQGTS EVKKVIDFLQ NEMGATNIRF 

       190        200        210        220        230        240 
PETSGIGIKP VSKEGTERLV RAAIQYALDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAH 

       250        260        270        280        290        300 
NEFGDKVFTW QQYDEIVEQK GKDAANEAQS KAEQEGKIII KDSIADIFLQ QILTRPAEHD 

       310        320        330        340        350        360 
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY AGLNKVNPSS 

       370        380        390        400        410        420 
EILSSVLMLE HLGWQEAADK ITDSIEATIA SKIVTYDFAR LMDGAKEVST SDFADELIKN 


IR

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References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO04969.1.
RefSeqNP_764925.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CNX4.
SMRQ8CNX4. Positions 3-421.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CNX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000040604; EBSTAP00000039237; EBSTAG00000040602.
GeneID1058012.
GenomeReviewsGene locus SE_1370 in contig AE015929_GR.
KEGGsep:SE1370.
PATRIC19608530. VBIStaEpi113981_1338.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
GeneTreeEBGT00050000023966.
HOGENOMHBG518924.
OMAFQQIQTR.
PhylomeDBQ8CNX4.
ProtClustDBPRK07006.

Enzyme and pathway databases

BioCycSEPI176280:SE_1370-MONOMER.

Family and domain databases

InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
KOK00031.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PTHR11835:SF1. NADP_IDH_prok. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. Prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_STAES
AccessionPrimary (citable) accession number: Q8CNX4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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