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Q8CNW8 (DHA_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine dehydrogenase
EC=1.4.1.1
Gene names
Name:ald
Ordered Locus Names:SE_1384
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer By similarity.

Catalytic activity

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH.

Pathway

Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.

Sequence similarities

Belongs to the AlaDH/PNT family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionalanine dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Alanine dehydrogenase
PRO_0000199007

Regions

Nucleotide binding169 – 19931NAD By similarity

Sites

Active site951 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8CNW8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 78541923F8E7CD6F

FASTA37140,195
        10         20         30         40         50         60 
MKIGIPKEIK NNENRVGLSP SGVHALVDQG HEVLVETNAG LGSYFEDGDY QEAGAKIVDE 

        70         80         90        100        110        120 
QSKAWDVDMV IKVKEPLESE YKFFKEELIL FTYLHLANEQ KLTQALVDNK VISIAYETVQ 

       130        140        150        160        170        180 
LPDGSLPLLT PMSEVAGRMS TQVGAEFLQR FNGGMGILLG GIPGVPKGKV TIIGGGQAGT 

       190        200        210        220        230        240 
NAAKIALGLG AEVTILDVNP KRLEELEDLF DGRVRTIMSN PLNIEMYVKE SDLVIGAVLI 

       250        260        270        280        290        300 
PGAKAPNLVT EDMIKEMKDG SVIVDIAIDQ GGIFETTDKI TTHDNPTYTK HGVVHYAVAN 

       310        320        330        340        350        360 
MPGAVPRTST IGLNNATLPY AQLLANKGYR EAFKVNHPLS LGLNTFNGHV TNKNVADTFN 

       370 
FEYTSIEDAL K

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References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO04983.1.
RefSeqNP_764939.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CNW8.
SMRQ8CNW8. Positions 1-359.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CNW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000040907; EBSTAP00000039540; EBSTAG00000040905.
GeneID1055853.
GenomeReviewsGene locus SE_1384 in contig AE015929_GR.
KEGGsep:SE1384.
PATRIC19608558. VBIStaEpi113981_1352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0686.
GeneTreeEBGT00050000024386.
HOGENOMHBG289735.
OMAVAHGHEV.
PhylomeDBQ8CNW8.
ProtClustDBCLSK885510.

Enzyme and pathway databases

BioCycSEPI176280:SE_1384-MONOMER.

Family and domain databases

InterProIPR008142. Ala_DH/PNT_CS1.
IPR008143. Ala_DH/PNT_CS2.
IPR008141. Ala_DH/Pyr_transHydgase.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
KOK00259.
PANTHERPTHR10160:SF3. PTHR10160:SF3. 1 hit.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFPIRSF000183. Alanine_dh. 1 hit.
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00518. AlaDH. 1 hit.
PROSITEPS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHA_STAES
AccessionPrimary (citable) accession number: Q8CNW8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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