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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-1414-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SE_1408
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993811 – 555Formate--tetrahydrofolate ligaseAdd BLAST555

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1408

Structurei

3D structure databases

ProteinModelPortaliQ8CNV9
SMRiQ8CNV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CNV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLSDLEIA NLSKLKPISE IARKVGITED ALEPYGHYKA KIDINQIQEQ
60 70 80 90 100
EKKGKVVLVT AMSPTPAGEG KSTVTVGLAD AFNKLNHNVT VALREPALGP
110 120 130 140 150
TFGIKGGATG GGYAQVLPME DINLHFNGDF HAITTANNAL SAFIDNHLHQ
160 170 180 190 200
GNELGIDQRR IEWKRVLDMN DRALRHVNVG LGGTTHGVPR EDGFNITVAS
210 220 230 240 250
EIMAILCLSR NIKDLKEKIS RITIGYTRHH KPITVSDLKV EGALTLILKD
260 270 280 290 300
AIKPNLVQTI EGTPALVHGG PFANIAHGCN SILATETARN LSDIVVTEAG
310 320 330 340 350
FGSDLGAEKF MNIKAREAGF DPSAVVVVAT IRALKMHGGV AKDQLQHENI
360 370 380 390 400
EAVEAGLVNL ERHVNNIKKY GVEPIVALNA FIHDTPSETA CVKQWAKDNQ
410 420 430 440 450
VRIALTEVWE KGGEGGIELA NQVFDVMQEP QNFKHLYELK QPLEAKIETI
460 470 480 490 500
VKEIYGGSKV NFSSKAQKQL KQFKENGWDE YPICMAKTQY SFSDDQTLLG
510 520 530 540 550
APNDFEITIR ELEAKTGAGF IVALTGAIMT MPGLPKKPAA LNMDVTDDGK

AIGLF
Length:555
Mass (Da):60,340
Last modified:March 1, 2003 - v1
Checksum:i9269FFF398EB5A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO05007.1
RefSeqiNP_764963.1, NC_004461.1
WP_002440219.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO05007; AAO05007; SE_1408
GeneIDi1056545
KEGGisep:SE1408
PATRICifig|176280.10.peg.1375

Entry informationi

Entry nameiFTHS_STAES
AccessioniPrimary (citable) accession number: Q8CNV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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