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Q8CNU8

- SYL_STAES

UniProt

Q8CNU8 - SYL_STAES

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Protein
Leucine--tRNA ligase
Gene
leuS, SE_1431
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1437-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SE_1431
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligaseUniRule annotation
PRO_0000152088Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1431.

Structurei

3D structure databases

ProteinModelPortaliQ8CNU8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CNU8-1 [UniParc]FASTAAdd to Basket

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MNYNHKEIEK KWQNYWEENK TFKTNDNLGQ KKFYALDMFP YPSGAGLHVG    50
HPEGYTATDI ISRYKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPREFT 100
QKNIQTFKRQ IQELGFSYDW DREVNTTDPE YYKWTQWIFI QLYNKGLAYV 150
DEVAVNWCPA LGTVLSNEEV VDGVSERGGH PVYRKPMKQW VLKITEYADR 200
LLEDLDELDW PESIKDMQRN WIGRSEGAKV TFKIEQSDQN IEVFTTRPDT 250
IYGTSFLVLS PEHPLVNEIT TSDKEQEVKL YQNEASKKSD LERTDLAKEK 300
TGVFTGTFAI NPLSGDKLPI WIADYVLSTY GTGAVMAVPG HDERDHEFAT 350
KFNLPIIEVI EGGEVQKYAY TGEGKHINSG ELDGLENEAA ISKAIELLES 400
KGAGEKKVNY KLRDWLFSRQ RYWGEPIPII HWEDGSMTTV PEDELPLLLP 450
ETDEIKPSGT GESPLANIDA FVNVIDEKTG MKGRRETNTM PQWAGSCWYY 500
LRYIDPHNEK MIADPEKLKH WLPVDLYIGG VEHAVLHLLY ARFWHKVLYD 550
LGVVPTKEPF QKLYNQGMIL GEGNEKMSKS KGNVINPDDI VASHGADTLR 600
LYEMFMGPLD AAIAWSEKGL DGSRRFLDRV WRLIITDENS INKKIVDSNN 650
HSLDKVYNQT VKKVTEDFDT LSFNTAISQL MVFINECYKT NEVYKPYIEG 700
FVKMLSPIAP HIGEELWDRL GHENTITYQP WPTFDESLLV DDEVEIVVQV 750
NGKVRAKINI PKDLSKEEMQ DLALSNDNVK MSIEGKEVKK VIAVPQKLVN 800
IVAK 804
Length:804
Mass (Da):92,164
Last modified:July 19, 2005 - v2
Checksum:i173B55466D9C0725
GO

Sequence cautioni

The sequence AAO05030.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05030.1. Different initiation.
RefSeqiNP_764986.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05030; AAO05030; SE_1431.
GeneIDi1056606.
KEGGisep:SE1431.
PATRICi19608648. VBIStaEpi113981_1397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05030.1 . Different initiation.
RefSeqi NP_764986.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CNU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO05030 ; AAO05030 ; SE_1431 .
GeneIDi 1056606.
KEGGi sep:SE1431.
PATRICi 19608648. VBIStaEpi113981_1397.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-1437-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiSYL_STAES
AccessioniPrimary (citable) accession number: Q8CNU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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