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Q8CNK7 (ALR_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:SE_1674
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Alanine racemase HAMAP-Rule MF_01201
PRO_0000114574

Sites

Active site391Proton acceptor; specific for D-alanine By similarity
Active site2651Proton acceptor; specific for L-alanine By similarity
Binding site1381Substrate By similarity
Binding site3121Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue391N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CNK7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 29973FA4077B7AF6

FASTA38242,955
        10         20         30         40         50         60 
MSEKFYRATY LNVNLDAILA NYQNFNQLHA NKTVISVIKA NGYGLGSVKI AQHLMRHGAT 

        70         80         90        100        110        120 
FFAVATLDEA IELRMHGVDA KLLVLGVVPT EDIEKAIQHR VALTVPSKAW LKETIKQIPD 

       130        140        150        160        170        180 
DNQKNLWLHV KLDTGMGRIG MKDIDEYKEV VDLINKRDHL VFEGVFTHFA SADEPGSSMN 

       190        200        210        220        230        240 
EQYTLFKEMV NQVEKPIYIH CQNSAGSLLM DGQFCNAIRL GISLYGYYPS EYVKDNVKVH 

       250        260        270        280        290        300 
LRPSAQLVSE TVQVKTLKVG ETVSYGRTFI ADEEMTIAIL PIGYADGYLR SMQGAFVNVN 

       310        320        330        340        350        360 
GSQCEVIGRI CMDQMIVKVP SHVKTGEKVI LMDNHVDSPQ SAEAVANKQG TINYEVLCNL 

       370        380 
SRRLPRIYYY DNNEEVTNEL LK 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015929 Genomic DNA. Translation: AAO05273.1.
RefSeqNP_765229.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CNK7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE1674.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO05273; AAO05273; SE_1674.
GeneID1056859.
KEGGsep:SE1674.
PATRIC19609212. VBIStaEpi113981_1635.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
KOK01775.
OMACIDEALT.
OrthoDBEOG6PP9NJ.
ProtClustDBCLSK885747.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-1724-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_STAES
AccessionPrimary (citable) accession number: Q8CNK7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways