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Q8CNI9

- PTPB_STAES

UniProt

Q8CNI9 - PTPB_STAES

Protein

Low molecular weight protein-tyrosine-phosphatase PtpB

Gene

ptpB

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Dephosphorylates the phosphotyrosine-containing proteins.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei7 – 71NucleophileBy similarity
    Active sitei13 – 131By similarity
    Active sitei111 – 1111Proton donorBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-1762-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low molecular weight protein-tyrosine-phosphatase PtpB (EC:3.1.3.48)
    Alternative name(s):
    Phosphotyrosine phosphatase B
    Short name:
    PTPase B
    Gene namesi
    Name:ptpB
    Ordered Locus Names:SE_1712
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Low molecular weight protein-tyrosine-phosphatase PtpBPRO_0000300680Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE1712.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CNI9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0394.
    KOiK01104.
    OMAiPMAMALL.
    OrthoDBiEOG6MH5JB.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    PRINTSiPR00719. LMWPTPASE.
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CNI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIIFVCSGN TCRSPLAESI AKSLLPHDSI ASRGLFAVEG QAISKESLEL    50
    IHKYDLPEPS RAQAFHIDDL DADIILTMTQ AHKDLIFSMY GRQSNVFTLN 100
    EYVGDTQEID DPFGGSFDVY EQTYTKIYDL VDKIKFKHE 139
    Length:139
    Mass (Da):15,709
    Last modified:March 1, 2003 - v1
    Checksum:i1E389CBAB81BA0C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05311.1.
    RefSeqiNP_765267.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO05311; AAO05311; SE_1712.
    GeneIDi1057316.
    KEGGisep:SE1712.
    PATRICi19609288. VBIStaEpi113981_1673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05311.1 .
    RefSeqi NP_765267.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CNI9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE1712.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO05311 ; AAO05311 ; SE_1712 .
    GeneIDi 1057316.
    KEGGi sep:SE1712.
    PATRICi 19609288. VBIStaEpi113981_1673.

    Phylogenomic databases

    eggNOGi COG0394.
    KOi K01104.
    OMAi PMAMALL.
    OrthoDBi EOG6MH5JB.

    Enzyme and pathway databases

    BioCyci SEPI176280:GCDG-1762-MONOMER.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR000106. Tyr_phospatase/Ars_reductase.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    PRINTSi PR00719. LMWPTPASE.
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiPTPB_STAES
    AccessioniPrimary (citable) accession number: Q8CNI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3