Reviewed, UniProtKB/Swiss-Prot Q8CNI5 (ALD1_STAES)

Names and origin

Protein names

Recommended name:
    Putative aldehyde dehydrogenase SE_1720
    EC=1.2.1.3

Gene names

Ordered Locus Names:

SE_1720

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Putative aldehyde dehydrogenase SE_1720		PRO_0000293561
Regions
	Nucleotide binding	201 – 207	7	NAD By similarity
Sites
	Active site	245	1	By similarity
	Active site	279	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CNI5-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 905E024191EE75D1	FASTA	475	51,890
	10 20 30 40 50 60 MRNFTKQYIN GEWVDSASGE TIDVINPATE EVMGKIAKGN EEDVNKAVDA ADKVYLEFRH 70 80 90 100 110 120 SSVEERRELL DKIVKEYQNR KNDLIEAITD ELGAPLSVSE NVHYQMGLNH FTAARDALDS 130 140 150 160 170 180 FQFEEQRGDD LVVKEAIGVA GLVTPWNFPT NQTSLKLAAA FAAGSPVVLK PSEETPFAAI 190 200 210 220 230 240 ILAEIFDKVG VPKGVFNLVN GDGSGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK 250 260 270 280 290 300 KVSLELGGKS PYIVLDDVDV EEAANATTKK VVNNTGQVCT AGTRVLIPES IKEDYLTAVK 310 320 330 340 350 360 EAFSKVKVGQ PREEGTQVGP IISKKQFDQV QDYIDKGINE GAELFYGGPG KPEGLDKGYF 370 380 390 400 410 420 ARPTIFINVD NHMTIAQEEI FGPVMSVITY NNLDEAIEIA NDTKYGLAGY VIGKDKDTLR 430 440 450 460 470 HVARSIEAGT IEINEAGRKP DLPFGGYKES GLGREWGDYG IEEFLEVKSI AGYFK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO05319.1.
RefSeq	NP_765275.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZUM based on UniProtKB P05091.
SMR	Q8CNI5. Positions 1-471.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CNI5.
Genome annotation databases
GeneID	1057384.
GenomeReviews	Gene locus SE_1720 in contig AE015929_GR.
KEGG	sep:SE1720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HBG752218.
OMA	QITINNA.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_1720-MONOMER.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALD1_STAES

Accession

Primary (citable) accession number: Q8CNI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	March 1, 2003
Last modified:	January 19, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)