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Q8CNI3

- ALF2_STAES

UniProt

Q8CNI3 - ALF2_STAES

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Protein
Fructose-bisphosphate aldolase
Gene
fba, fbaA, SE_1723
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Glyceraldehyde 3-phosphate By similarity
Active sitei85 – 851Proton donor By similarity
Metal bindingi86 – 861Zinc 1; catalytic By similarity
Metal bindingi107 – 1071Zinc 2 By similarity
Metal bindingi137 – 1371Zinc 2 By similarity
Metal bindingi181 – 1811Zinc 1; catalytic By similarity
Binding sitei182 – 1821Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi209 – 2091Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1773-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fbaA
Ordered Locus Names:SE_1723
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Fructose-bisphosphate aldolase
PRO_0000178741Add
BLAST

Proteomic databases

PRIDEiQ8CNI3.

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1723.

Structurei

3D structure databases

ProteinModelPortaliQ8CNI3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2123Dihydroxyacetone phosphate binding By similarity
Regioni231 – 2344Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiTCVTAIQ.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CNI3-1 [UniParc]FASTAAdd to Basket

« Hide

MPLVSMKEML IDAKENGYAV GQYNLNNLEF TQAILEASQE ENAPVILGVS    50
EGAARYMSGF YTVVKMVEGL MHDLNITIPV AIHLDHGSSF EKCKEAIDAG 100
FTSVMIDASH SPFEENVEIT SKVVEYAHDR GVSVEAELGT VGGQEDDVVA 150
DGVIYADPKE CQELVEKTGI DTLAPALGSV HGPYKGEPKL GFKEMEEIGA 200
STGLPLVLHG GTGIPTKDIQ KAIPYGTAKI NVNTENQIAS AKAVREVLNN 250
DKDVYDPRKY LGPAREAIKE TVKGKIREFG TSNRAK 286
Length:286
Mass (Da):30,883
Last modified:March 1, 2003 - v1
Checksum:iD11CBF24BAE3B4E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05322.1.
RefSeqiNP_765278.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05322; AAO05322; SE_1723.
GeneIDi1057228.
KEGGisep:SE1723.
PATRICi19609308. VBIStaEpi113981_1683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05322.1 .
RefSeqi NP_765278.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CNI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1723.

Proteomic databases

PRIDEi Q8CNI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO05322 ; AAO05322 ; SE_1723 .
GeneIDi 1057228.
KEGGi sep:SE1723.
PATRICi 19609308. VBIStaEpi113981_1683.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi TCVTAIQ.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci SEPI176280:GCDG-1773-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiALF2_STAES
AccessioniPrimary (citable) accession number: Q8CNI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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