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Q8CNF8

- LACG_STAES

UniProt

Q8CNF8 - LACG_STAES

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Protein

6-phospho-beta-galactosidase

Gene
lacG, SE_1781
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donor By similarity
Active sitei375 – 3751Nucleophile By similarity

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1840-MONOMER.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase (EC:3.2.1.85)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name:
PGALase
P-beta-Gal
Short name:
PBG
Gene namesi
Name:lacG
Ordered Locus Names:SE_1781
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4704706-phospho-beta-galactosidaseUniRule annotationPRO_0000063891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1781.

Structurei

3D structure databases

ProteinModelPortaliQ8CNF8.
SMRiQ8CNF8. Positions 1-470.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2723.
KOiK01220.
OMAiANESIPR.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CNF8-1 [UniParc]FASTAAdd to Basket

« Hide

MTKKLPDDFI FGGATAAYQA EGATQTDGKG RVAWDTYLEE NYWYTAEPAS    50
DFYNRYPVDL ELSERFGVNG IRISIAWSRI FPKGYGEVNQ KGVEYYHNLF 100
KECHKRHVEP FVTLHHFDTP EVLHKDGDFL NRKTIDYFVD YAEFCFKEFP 150
EVKYWTTFNE IGPIGDGQYL VGKFPPGIKY DFEKVFQSHH NMMVAHARAV 200
KLFKDENYKG EIGVVHALPT KYPYDPSNPE DVRAAELEDI IHNKFILDAT 250
YLGKYSRETM EGVQHILSVN GGQLEISDED YKILDEAKDL NDFLGINYYM 300
SDWMRGFEGE SEITHNATGD KGGSKYQLKG VGQREFDVDV PRTDWDWMIY 350
PQGLYDQIMR VVKDYPNYHK IYITENGLGY KDVFDEKEKT VHDDARIDYI 400
KQHLSVIADA IADGANVKGY FLWSLMDVFS WSNGYEKRYG LFYVDFETQE 450
RFPKKSAYWY KELAESKEIK 470
Length:470
Mass (Da):54,836
Last modified:March 1, 2003 - v1
Checksum:iE81C610AB95A77EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05422.1.
RefSeqiNP_765336.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05422; AAO05422; SE_1781.
GeneIDi1057113.
KEGGisep:SE1781.
PATRICi19609436. VBIStaEpi113981_1738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05422.1 .
RefSeqi NP_765336.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CNF8.
SMRi Q8CNF8. Positions 1-470.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1781.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO05422 ; AAO05422 ; SE_1781 .
GeneIDi 1057113.
KEGGi sep:SE1781.
PATRICi 19609436. VBIStaEpi113981_1738.

Phylogenomic databases

eggNOGi COG2723.
KOi K01220.
OMAi ANESIPR.
OrthoDBi EOG60658J.

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
BioCyci SEPI176280:GCDG-1840-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiLACG_STAES
AccessioniPrimary (citable) accession number: Q8CNF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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