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Protein

Oxygen regulatory protein NreC

Gene

nreC

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi173 – 192H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen regulatory protein NreC
Alternative name(s):
Nitrogen regulation protein C
Gene namesi
Name:nreC
Ordered Locus Names:SE_1969
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493571 – 218Oxygen regulatory protein NreCAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by NreB.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1969.

Structurei

3D structure databases

ProteinModelPortaliQ8CN75.
SMRiQ8CN75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini149 – 214HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
KOiK07696.
OMAiSHKTRIM.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
cd00156. REC. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
PRINTSiPR00038. HTHLUXR.
SMARTiView protein in SMART
SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CN75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVIADDHA VVRTGFSMIL NYQEDMEVVA TAADGVEAYQ KVLEHRPDVL
60 70 80 90 100
ILDLSMPPGE SGLIATSKIS ESFPETKILI LTMFDDEEYL FHMLKSGAKG
110 120 130 140 150
YILKNSPDEQ LILAVRTVYQ GETYVDMKLT TSLVNEFVNQ SQTDEVSSSS
160 170 180 190 200
DPFKILSKRE LEILPLIAKG YGNKDIAEKL FVSVKTVEAH KTHIMTKLNL
210
KSKPELVEYA LKKKLLEF
Length:218
Mass (Da):24,517
Last modified:March 1, 2003 - v1
Checksum:iB27EF1E7FB4D8291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05610.1.
RefSeqiNP_765524.1. NC_004461.1.
WP_002485230.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05610; AAO05610; SE_1969.
GeneIDi1055872.
KEGGisep:SE1969.
PATRICifig|176280.10.peg.1922.

Similar proteinsi

Entry informationi

Entry nameiNREC_STAES
AccessioniPrimary (citable) accession number: Q8CN75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome