Reviewed, UniProtKB/Swiss-Prot Q8CN38 (PGCA_STAES)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase
      Short name=PGM
    EC=5.4.2.2
Alternative name(s):
    Alpha-phosphoglucomutase
    Glucose phosphomutase

Gene names

Name:	pgcA
Ordered Locus Names:	SE_2042

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	Phosphoglucomutase		PRO_0000308346
Sites
	Active site	135	1	Phosphoserine intermediate By similarity
	Metal binding	135	1	Magnesium; via phosphate group By similarity
	Metal binding	288	1	Magnesium By similarity
	Metal binding	290	1	Magnesium By similarity
	Metal binding	292	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CN38-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: AAE01A6922EC88EC	FASTA	546	60,899
	10 20 30 40 50 60 MKNNWIDVLD ESLVKDFYNN QTSEEQQEGL NTTLSFGTAG IRGKFGLGEG RLNKFTVSKV 70 80 90 100 110 120 ALGFAHYLTS SIAHPVVVIH YDTRHLSPEF AQIIANILAS LDIKVYLADT YRTTPDLSFA 130 140 150 160 170 180 VRYLQADAGV MITASHNPKD YNGIKVYGED GAQLSTDDSA RLSTYIDKLG HPLHINLPSL 190 200 210 220 230 240 TTEQQSLIHS VPSEVREDYF KNVQDLVGTI PQSDLKVVFT SLHGTSVPVV PDILSSLNFN 250 260 270 280 290 300 QFELVASQCE PDSDFSSVAS ANPEDHKAFD QSIELANLID ADLLIGTDPD ADRLGIVERD 310 320 330 340 350 360 AEGNIYYYNG NQIGALLLNY RIKQTEGLPN RIMFQSIVSG GLAKSLAQYH NVNFKEVLTG 370 380 390 400 410 420 FKYIAAEIRH LSPEQNFIFG YEESYGFLAR PFVRDKDAIQ IVPLMIKYAA ELKNEGRMLK 430 440 450 460 470 480 DELEDITRNV GNFNDKLFSH TFEGTQGKAK IENIMTQFRS ETPTEMCGLK VIAIEDFETG 490 500 510 520 530 540 KKTDLQNDEV SDITLPKANV IKIYFNEGFI ALRPSGTEPK IKLYVSLSCD HFDVIAQKIN DAIFNS

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015929 Genomic DNA. Translation: AAO05683.1.
RefSeq	NP_765597.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CN38.
Genome annotation databases
GeneID	1057755.
GenomeReviews	Gene locus SE_2042 in contig AE015929_GR.
KEGG	sep:SE2042.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8CN38.
OMA	PKIKCYY.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_2042-MON.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGCA_STAES

Accession

Primary (citable) accession number: Q8CN38

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)