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Protein

Putative aldehyde dehydrogenase AldA

Gene

aldA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571By similarity
Active sitei291 – 2911By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2197NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-2130-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase AldA (EC:1.2.1.3)
Gene namesi
Name:aldA
Ordered Locus Names:SE_2071
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Putative aldehyde dehydrogenase AldAPRO_0000056461Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2071.

Structurei

3D structure databases

ProteinModelPortaliQ8CN24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
KOiK00128.
OMAiGNTVAYH.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CN24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNINVRNYI DESYGLFINN EFQASDSGET LTVSNPANGE DLAKVARAGK
60 70 80 90 100
KDVDKAVQAA HDAFDSWSKI SKEERADYLL EISRRIHEKT EHLATVESLQ
110 120 130 140 150
NGKPYRETST IDVPQAANQF KYFASVLTTD EGSVNEIDQN TMSLVVNEPV
160 170 180 190 200
GVVGAVVAWN FPILLASWKL GPALAAGNTV VIQPSSSTPL SLIELAKIFQ
210 220 230 240 250
EVLPKGVVNV LTGKGSESGD AIFHHEGVDK LSFTGSTDVG YGVAQAGAER
260 270 280 290 300
IVPTTLELGG KSANIIFDDA NLEQVIEGVQ LGILFNQGEV CSAGSRLLVQ
310 320 330 340 350
SSIYDELLPK LKEAFENIKV GDPFDEDTKM SAQTGPEQLD KIESYIKIAE
360 370 380 390 400
EDDKANILTG GHRITDNGLD KGYFFEPTII EINDNKHQLA QEEIFGPVVV
410 420 430 440 450
VEKFDDEQEA IEIANDSEYG LAGGIFTTDI HRALNVAKAM RTGRIWINTY
460 470 480 490
NQIPAGAPFG GYKKSGIGRE VYKDAIKNYQ QVKNIFIDTS NQTKGLY
Length:497
Mass (Da):54,247
Last modified:March 1, 2003 - v1
Checksum:iDDCD2D2E0F2FDA7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05713.1.
RefSeqiNP_765626.1. NC_004461.1.
WP_002438147.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05713; AAO05713; SE_2071.
GeneIDi1057715.
KEGGisep:SE2071.
PATRICi19610006. VBIStaEpi113981_2023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05713.1.
RefSeqiNP_765626.1. NC_004461.1.
WP_002438147.1. NC_004461.1.

3D structure databases

ProteinModelPortaliQ8CN24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176280.SE2071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO05713; AAO05713; SE_2071.
GeneIDi1057715.
KEGGisep:SE2071.
PATRICi19610006. VBIStaEpi113981_2023.

Phylogenomic databases

eggNOGiCOG1012.
KOiK00128.
OMAiGNTVAYH.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-2130-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiALDA_STAES
AccessioniPrimary (citable) accession number: Q8CN24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.