Reviewed, UniProtKB/Swiss-Prot Q8CN24 (ALDA_STAES)

Names and origin

Protein names

Recommended name:
    Putative aldehyde dehydrogenase aldA
    EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	SE_2071

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Putative aldehyde dehydrogenase aldA		PRO_0000056461
Regions
	Nucleotide binding	213 – 219	7	NAD By similarity
Sites
	Active site	257	1	By similarity
	Active site	291	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CN24-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DDCD2D2E0F2FDA7E	FASTA	497	54,247
	10 20 30 40 50 60 MTNINVRNYI DESYGLFINN EFQASDSGET LTVSNPANGE DLAKVARAGK KDVDKAVQAA 70 80 90 100 110 120 HDAFDSWSKI SKEERADYLL EISRRIHEKT EHLATVESLQ NGKPYRETST IDVPQAANQF 130 140 150 160 170 180 KYFASVLTTD EGSVNEIDQN TMSLVVNEPV GVVGAVVAWN FPILLASWKL GPALAAGNTV 190 200 210 220 230 240 VIQPSSSTPL SLIELAKIFQ EVLPKGVVNV LTGKGSESGD AIFHHEGVDK LSFTGSTDVG 250 260 270 280 290 300 YGVAQAGAER IVPTTLELGG KSANIIFDDA NLEQVIEGVQ LGILFNQGEV CSAGSRLLVQ 310 320 330 340 350 360 SSIYDELLPK LKEAFENIKV GDPFDEDTKM SAQTGPEQLD KIESYIKIAE EDDKANILTG 370 380 390 400 410 420 GHRITDNGLD KGYFFEPTII EINDNKHQLA QEEIFGPVVV VEKFDDEQEA IEIANDSEYG 430 440 450 460 470 480 LAGGIFTTDI HRALNVAKAM RTGRIWINTY NQIPAGAPFG GYKKSGIGRE VYKDAIKNYQ 490 QVKNIFIDTS NQTKGLY

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015929 Genomic DNA. Translation: AAO05713.1.
RefSeq	NP_765626.1.
3D structure databases
HSSP	HSSP built from PDB template 1BI9 based on UniProtKB Q63639.
ModBase	Search...
Genome annotation databases
GeneID	1057715.
GenomeReviews	Gene locus SE_2071 in contig AE015929_GR.
KEGG	sep:SE2071.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8CN24.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_2071-MON.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDA_STAES

Accession

Primary (citable) accession number: Q8CN24

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	March 1, 2003
Last modified:	November 4, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)