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Q8CN24 (ALDA_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative aldehyde dehydrogenase AldA
EC=1.2.1.3
Gene names
Name:aldA
Ordered Locus Names:SE_2071
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Putative aldehyde dehydrogenase AldA
PRO_0000056461

Regions

Nucleotide binding213 – 2197NAD By similarity

Sites

Active site2571 By similarity
Active site2911 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CN24 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: DDCD2D2E0F2FDA7E

FASTA49754,247
        10         20         30         40         50         60 
MTNINVRNYI DESYGLFINN EFQASDSGET LTVSNPANGE DLAKVARAGK KDVDKAVQAA 

        70         80         90        100        110        120 
HDAFDSWSKI SKEERADYLL EISRRIHEKT EHLATVESLQ NGKPYRETST IDVPQAANQF 

       130        140        150        160        170        180 
KYFASVLTTD EGSVNEIDQN TMSLVVNEPV GVVGAVVAWN FPILLASWKL GPALAAGNTV 

       190        200        210        220        230        240 
VIQPSSSTPL SLIELAKIFQ EVLPKGVVNV LTGKGSESGD AIFHHEGVDK LSFTGSTDVG 

       250        260        270        280        290        300 
YGVAQAGAER IVPTTLELGG KSANIIFDDA NLEQVIEGVQ LGILFNQGEV CSAGSRLLVQ 

       310        320        330        340        350        360 
SSIYDELLPK LKEAFENIKV GDPFDEDTKM SAQTGPEQLD KIESYIKIAE EDDKANILTG 

       370        380        390        400        410        420 
GHRITDNGLD KGYFFEPTII EINDNKHQLA QEEIFGPVVV VEKFDDEQEA IEIANDSEYG 

       430        440        450        460        470        480 
LAGGIFTTDI HRALNVAKAM RTGRIWINTY NQIPAGAPFG GYKKSGIGRE VYKDAIKNYQ 

       490 
QVKNIFIDTS NQTKGLY

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References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO05713.1.
RefSeqNP_765626.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CN24.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CN24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000040969; EBSTAP00000039602; EBSTAG00000040967.
GeneID1057715.
GenomeReviewsGene locus SE_2071 in contig AE015929_GR.
KEGGsep:SE2071.
PATRIC19610006. VBIStaEpi113981_2023.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00050000023967.
HOGENOMHBG752218.
OMAIFNHEGV.
PhylomeDBQ8CN24.
ProtClustDBCLSK884447.

Enzyme and pathway databases

BioCycSEPI176280:SE_2071-MONOMER.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00128.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDA_STAES
AccessionPrimary (citable) accession number: Q8CN24
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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