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Q8CN24

- ALDA_STAES

UniProt

Q8CN24 - ALDA_STAES

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Protein

Putative aldehyde dehydrogenase AldA

Gene

aldA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571By similarity
Active sitei291 – 2911By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2197NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-2130-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase AldA (EC:1.2.1.3)
Gene namesi
Name:aldA
Ordered Locus Names:SE_2071
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Putative aldehyde dehydrogenase AldAPRO_0000056461Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2071.

Structurei

3D structure databases

ProteinModelPortaliQ8CN24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
KOiK00128.
OMAiHDQFVER.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CN24 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNINVRNYI DESYGLFINN EFQASDSGET LTVSNPANGE DLAKVARAGK
60 70 80 90 100
KDVDKAVQAA HDAFDSWSKI SKEERADYLL EISRRIHEKT EHLATVESLQ
110 120 130 140 150
NGKPYRETST IDVPQAANQF KYFASVLTTD EGSVNEIDQN TMSLVVNEPV
160 170 180 190 200
GVVGAVVAWN FPILLASWKL GPALAAGNTV VIQPSSSTPL SLIELAKIFQ
210 220 230 240 250
EVLPKGVVNV LTGKGSESGD AIFHHEGVDK LSFTGSTDVG YGVAQAGAER
260 270 280 290 300
IVPTTLELGG KSANIIFDDA NLEQVIEGVQ LGILFNQGEV CSAGSRLLVQ
310 320 330 340 350
SSIYDELLPK LKEAFENIKV GDPFDEDTKM SAQTGPEQLD KIESYIKIAE
360 370 380 390 400
EDDKANILTG GHRITDNGLD KGYFFEPTII EINDNKHQLA QEEIFGPVVV
410 420 430 440 450
VEKFDDEQEA IEIANDSEYG LAGGIFTTDI HRALNVAKAM RTGRIWINTY
460 470 480 490
NQIPAGAPFG GYKKSGIGRE VYKDAIKNYQ QVKNIFIDTS NQTKGLY
Length:497
Mass (Da):54,247
Last modified:March 1, 2003 - v1
Checksum:iDDCD2D2E0F2FDA7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05713.1.
RefSeqiNP_765626.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05713; AAO05713; SE_2071.
GeneIDi1057715.
KEGGisep:SE2071.
PATRICi19610006. VBIStaEpi113981_2023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05713.1 .
RefSeqi NP_765626.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CN24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE2071.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO05713 ; AAO05713 ; SE_2071 .
GeneIDi 1057715.
KEGGi sep:SE2071.
PATRICi 19610006. VBIStaEpi113981_2023.

Phylogenomic databases

eggNOGi COG1012.
KOi K00128.
OMAi HDQFVER.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-2130-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiALDA_STAES
AccessioniPrimary (citable) accession number: Q8CN24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3