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Q8CN07 (Q8CN07_STAES) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Hydroxymethylglutaryl-CoA reductase EMBL AAO05751.1
Gene names
Ordered Locus Names:SE_2109
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the HMG-CoA reductase family. RuleBase RU004268

Ontologies

Keywords
   Molecular functionOxidoreductase RuleBase RU004269
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcoenzyme A metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8CN07 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0B5E4F05E80E7DEC

FASTA42546,274
        10         20         30         40         50         60 
MKSLDKGFRH LTRKDKLKKL VEYGWLDDEN YEILLNHPLI NEEVANSLIE NVIGQGALPV 

        70         80         90        100        110        120 
GLLPRIIVDD KEYVVPMMVE EPSVVAAASY GAKLVNQSGG FKTISSERLM IGQIVFDDVE 

       130        140        150        160        170        180 
DTGTLANSIY QIESQIHQIA DEAYPSIKAR GGGYQRIEID TFPNHRLLSL KVFVDTKDAM 

       190        200        210        220        230        240 
GANMLNTILE AITAHLKVKF SNQNVLMSIL SNHATASVVK VQGEIDIEDL HRGERSGEEV 

       250        260        270        280        290        300 
AQRMERASVL AQVDIHRAAT HNKGVMNGIH AVVLATGNDT RGVEASAHAY ASKDGHYRGI 

       310        320        330        340        350        360 
ATWEYDRSRN KLVGTIEVPM TLATVGGGTK VLPIAKASLN LLNVENAQEL GQVVAAVGLA 

       370        380        390        400        410        420 
QNFSACRALV SEGIQQGHMS LQYKSLAIVV GAKGEEIAQV AEALKYESQA NTAKAQEILM 


NIRKS

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References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO05751.1.
RefSeqNP_765664.1. NC_004461.1.

3D structure databases

HSSPHSSP built from PDB template 1QAY based on UniProtKB P13702.
ProteinModelPortalQ8CN07.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CN07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000041010; EBSTAP00000039643; EBSTAG00000041008.
GeneID1056094.
GenomeReviewsGene locus SE_2109 in contig AE015929_GR.
KEGGsep:SE2109.
PATRIC19610080. VBIStaEpi113981_2060.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1257.
GeneTreeEBGT00050000024128.
HOGENOMHBG477902.
OMANNKGIMN.
PhylomeDBQ8CN07.
ProtClustDBCLSK886059.

Enzyme and pathway databases

BioCycSEPI176280:SE_2109-MONOMER.

Family and domain databases

InterProIPR002202. HMG_CoA_Rdtase.
IPR004553. HMG_CoA_Rdtase_bac-typ.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd.
IPR009029. HMG_CoA_Rdtase_sub-bd.
[Graphical view]
Gene3DG3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit.
G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
KOK00054.
PfamPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSPR00071. HMGCOARDTASE.
SUPFAMSSF55035. HMG_CoA_NAD_bind. 1 hit.
SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMsTIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITEPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8CN07_STAES
AccessionPrimary (citable) accession number: Q8CN07
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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