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Reviewed, UniProtKB/Swiss-Prot Q8CN04 (ROCA_STAES)

Last modified November 25, 2008. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    1-pyrroline-5-carboxylate dehydrogenase
      Short name=P5C dehydrogenase
    EC=1.5.1.12
Gene names
Name: rocA
Ordered Locus Names: SE_2116
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5145141-pyrroline-5-carboxylate dehydrogenase
PRO_0000056520

Sites

Active site2861 By similarity
Active site3201 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CN04-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 99EE786D43629FF4

FASTA51456,876
        10         20         30         40         50         60 
MVVPFKNEPG IDFSVQTNVE RFNEELRKVK AQLGQDIPLV INGEKLTKTD TFNSVNPANT 

        70         80         90        100        110        120 
SQLIAKVSKA TQDDIEKAFE SANHAYQSWK KWSHKDRAEL LLRVAAIIRR RKEEISAIMV 

       130        140        150        160        170        180 
YEAGKPWDEA VGDAAEGIDF IEYYARSMME LADGKPVLDR EGEHNRYFYK PIGTGVTIPP 

       190        200        210        220        230        240 
WNFPFAIMAG TTLAPVVAGN TVLLKPAEDT VLTAYKLMEI LEEAGLPQGV VNFVPGDPKE 

       250        260        270        280        290        300 
IGDYLVDHKD THFVTFTGSR ATGTRIYERS AVVQEGQQFL KRVIAEMGGK DAIVVDNNVD 

       310        320        330        340        350        360 
TDLAAEAIVT SAFGFSGQKC SACSRAIVHQ DVHDEILEKA IQLTQKLTLG NTEENTFMGP 

       370        380        390        400        410        420 
VINQKQFDKI KNYIEIGKKE GKLETGGGTD DSTGYFIEPT IFSGLQSADR IMQEEIFGPV 

       430        440        450        460        470        480 
VGFIKVKDFD EAIEVANDTD YGLTGAVITN HREHWIKAVN EFDVGNLYLN RGCTAAVVGY 

       490        500        510 
HPFGGFKMSG TDAKTGSPDY LLNFLEQKVV SEMF 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AE015929 Genomic DNA. Translation: AAO05758.1.
RefSeqNP_765671.1.

3D structure databases

HSSPHSSP built from PDB template 1O9J based on UniProtKB Q28399.
ModBaseSearch...

Genome annotation databases

GeneID1057207.
GenomeReviewsGene locus SE_2116 in contig AE015929_GR.
KEGGsep:SE2116.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8CN04.

Enzyme and pathway databases

BioCycSEPI176280:SE_2116-MON.

Family and domain databases

HAMAPMF_00733.
[Tree]
InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR015590. Aldehyde_DHase.
IPR005932. d-1-pyrroline-5-COlate_DHase-2.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameROCA_STAES
AccessionPrimary (citable) accession number: Q8CN04
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: November 25, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents