Q8CMY4 (MQO4_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase 4
EC=1.1.5.4

Alternative name(s):
MQO 4
Malate dehydrogenase [quinone] 4

Gene names

Name:	mqo4
Ordered Locus Names:	SE_2158

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Probable malate:quinone oxidoreductase 4 HAMAP MF_00212		PRO_0000128752

Sequences

	Sequence		Length	Mass (Da)
	Q8CMY4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: BB079D0587E7CFE4	FASTA	499	56,353
	10 20 30 40 50 60 MAMSDKKDVV LIGAGVLSTT FGSMLKTIAP DWDIHLYERL DRPGIESSNE RNNAGTGHAA 70 80 90 100 110 120 LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GEIQNPKEFI NPLPHISFVR 130 140 150 160 170 180 GKNNVKFLKD RYEAMKQFPM FDNIEYTEDI EEMRKWIPLM MKGREDKGYM AASKIDEGTD 190 200 210 220 230 240 VNYGELTRKM AQNLKNSPNV EVQYKHEVVD FERLSNGKWS VKIKNLNNGQ VFEHQTDYVF 250 260 270 280 290 300 IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FIACTNPQVI EQHDAKVYGK EPPGTPPMTV 310 320 330 340 350 360 PHLDTRYIDG ERTLLFGPFA NVGPKFLKHG SNLDLFKSIK PYNITTLLAS AVKNLPLIKY 370 380 390 400 410 420 SFDQVIMTKE GCMNHLRTFY PEARDEDWQV YTAGKRVQVI KDTEENGKGF IQFGTEVVNS 430 440 450 460 470 480 EDHSVIALLG ESPGASTSVS VALEVLEKNF PEYAKDWEPK IKKMIPSYGE SLIDDVQLMR 490 KIRKQTSKDL ELGFYNKAK

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO05800.1.
RefSeq	NP_765713.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CMY4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CMY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000040208; EBSTAP00000038841; EBSTAG00000040206.
GeneID	1056255.
GenomeReviews	Gene locus SE_2158 in contig AE015929_GR.
KEGG	sep:SE2158.
PATRIC	19610176. VBIStaEpi113981_2108.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
GeneTree	EBGT00050000024300.
HOGENOM	HBG289663.
OMA	NSEDHSV.
PhylomeDB	Q8CMY4.
ProtClustDB	PRK13339.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_2158-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO4_STAES

Accession

Primary (citable) accession number: Q8CMY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program