ID   BETA_STAES              Reviewed;         572 AA.
AC   Q8CMY2;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 43.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=SE_2165;
OS   Staphylococcus epidermidis (strain ATCC 12228).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22832016; PubMed=12950922;
RX   DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J.,
RA   Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z.,
RA   Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; AE015929; AAO05807.1; -; Genomic_DNA.
DR   RefSeq; NP_765720.1; -.
DR   GeneID; 1056313; -.
DR   GenomeReviews; AE015929_GR; SE_2165.
DR   KEGG; sep:SE2165; -.
DR   HOGENOM; Q8CMY2; -.
DR   OMA; Q8CMY2; PNLQYHF.
DR   BioCyc; SEPI176280:SE_2165-MON; -.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    572       Choline dehydrogenase.
FT                                /FTId=PRO_0000205601.
FT   NP_BIND       9     38       FAD (Probable).
FT   ACT_SITE    477    477       By similarity.
SQ   SEQUENCE   572 AA;  64261 MW;  7264C59BDCF9072A CRC64;
     MRRKRDSYDY VIIGGGSAGS VLGARLSEDK DKNVLVLEAG RSDYFWDLFI QMPAALMFPS
     GNRFYDWEYQ TDEEPHMGRR VDHARGKVLG GSSSINGMIY QRGNPMDYEG WAEPEGMDTW
     DFAHCLPYFK KLETTYGAAP YDKVRGHDGP IKLKRGPATN PLFKSFFNAG VEAGYHKTAD
     VNGYRQEGFG PFDSQVHHGR RMSASRAYLR PALRRRNLDV ETRAFVTKLI FDENNSKKVT
     GVTFKKNGKE HTVHANEVIL SGGAFNTPQL LQLSGIGDSE FLKSKGIEPR MHLPGVGENF
     EDHLEVYIQH KCKQPVSLQP SLDVKRMPFI GLQWIFARKG AAASNHFEGG GFVRSNDDVD
     YPNLMFHFLP IAVRYDGQKA PVAHGYQVHV GPMYSNSRGS LKIKSKDPFE KPSIVFNYLS
     TKEDEREWVE AIRVARNILK QKAMDPFNGG EISPGPQVQT DEEILDWVRK DGETALHPSC
     SAKMGPASDP MAVVDPLTMK VHGMENLRVV DASAMPRTTN GNIHAPVLML AEKAADIIRG
     RKPLEPQYVD YYKHGIDDEK AGAMEDDPFY QY
//