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Q8CMY2

- BETA_STAES

UniProt

Q8CMY2 - BETA_STAES

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei477 – 4771UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 3830FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-2224-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:SE_2165
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Oxygen-dependent choline dehydrogenasePRO_0000205601Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE2165.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CMY2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    KOiK00108.
    OMAiTHGAMIS.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CMY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRKRDSYDY VIIGGGSAGS VLGARLSEDK DKNVLVLEAG RSDYFWDLFI    50
    QMPAALMFPS GNRFYDWEYQ TDEEPHMGRR VDHARGKVLG GSSSINGMIY 100
    QRGNPMDYEG WAEPEGMDTW DFAHCLPYFK KLETTYGAAP YDKVRGHDGP 150
    IKLKRGPATN PLFKSFFNAG VEAGYHKTAD VNGYRQEGFG PFDSQVHHGR 200
    RMSASRAYLR PALRRRNLDV ETRAFVTKLI FDENNSKKVT GVTFKKNGKE 250
    HTVHANEVIL SGGAFNTPQL LQLSGIGDSE FLKSKGIEPR MHLPGVGENF 300
    EDHLEVYIQH KCKQPVSLQP SLDVKRMPFI GLQWIFARKG AAASNHFEGG 350
    GFVRSNDDVD YPNLMFHFLP IAVRYDGQKA PVAHGYQVHV GPMYSNSRGS 400
    LKIKSKDPFE KPSIVFNYLS TKEDEREWVE AIRVARNILK QKAMDPFNGG 450
    EISPGPQVQT DEEILDWVRK DGETALHPSC SAKMGPASDP MAVVDPLTMK 500
    VHGMENLRVV DASAMPRTTN GNIHAPVLML AEKAADIIRG RKPLEPQYVD 550
    YYKHGIDDEK AGAMEDDPFY QY 572
    Length:572
    Mass (Da):64,261
    Last modified:March 1, 2003 - v1
    Checksum:i7264C59BDCF9072A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05807.1.
    RefSeqiNP_765720.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO05807; AAO05807; SE_2165.
    GeneIDi1056313.
    KEGGisep:SE2165.
    PATRICi19610190. VBIStaEpi113981_2115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05807.1 .
    RefSeqi NP_765720.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CMY2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE2165.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO05807 ; AAO05807 ; SE_2165 .
    GeneIDi 1056313.
    KEGGi sep:SE2165.
    PATRICi 19610190. VBIStaEpi113981_2115.

    Phylogenomic databases

    eggNOGi COG2303.
    KOi K00108.
    OMAi THGAMIS.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci SEPI176280:GCDG-2224-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiBETA_STAES
    AccessioniPrimary (citable) accession number: Q8CMY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3