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Q8CMY2 (BETA_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1
Gene names
Name:betA
Ordered Locus Names:SE_2165
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750

Cofactor

FAD By similarity. HAMAP MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Choline dehydrogenase HAMAP MF_00750
PRO_0000205601

Regions

Nucleotide binding9 – 3830FAD Potential

Sites

Active site4771 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CMY2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7264C59BDCF9072A

FASTA57264,261
        10         20         30         40         50         60 
MRRKRDSYDY VIIGGGSAGS VLGARLSEDK DKNVLVLEAG RSDYFWDLFI QMPAALMFPS 

        70         80         90        100        110        120 
GNRFYDWEYQ TDEEPHMGRR VDHARGKVLG GSSSINGMIY QRGNPMDYEG WAEPEGMDTW 

       130        140        150        160        170        180 
DFAHCLPYFK KLETTYGAAP YDKVRGHDGP IKLKRGPATN PLFKSFFNAG VEAGYHKTAD 

       190        200        210        220        230        240 
VNGYRQEGFG PFDSQVHHGR RMSASRAYLR PALRRRNLDV ETRAFVTKLI FDENNSKKVT 

       250        260        270        280        290        300 
GVTFKKNGKE HTVHANEVIL SGGAFNTPQL LQLSGIGDSE FLKSKGIEPR MHLPGVGENF 

       310        320        330        340        350        360 
EDHLEVYIQH KCKQPVSLQP SLDVKRMPFI GLQWIFARKG AAASNHFEGG GFVRSNDDVD 

       370        380        390        400        410        420 
YPNLMFHFLP IAVRYDGQKA PVAHGYQVHV GPMYSNSRGS LKIKSKDPFE KPSIVFNYLS 

       430        440        450        460        470        480 
TKEDEREWVE AIRVARNILK QKAMDPFNGG EISPGPQVQT DEEILDWVRK DGETALHPSC 

       490        500        510        520        530        540 
SAKMGPASDP MAVVDPLTMK VHGMENLRVV DASAMPRTTN GNIHAPVLML AEKAADIIRG 

       550        560        570 
RKPLEPQYVD YYKHGIDDEK AGAMEDDPFY QY

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO05807.1.
RefSeqNP_765720.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CMY2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CMY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000041134; EBSTAP00000039767; EBSTAG00000041132.
GeneID1056313.
GenomeReviewsGene locus SE_2165 in contig AE015929_GR.
KEGGsep:SE2165.
PATRIC19610190. VBIStaEpi113981_2115.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
GeneTreeEBGT00050000024944.
HOGENOMHBG734713.
OMARSTAPYY.
PhylomeDBQ8CMY2.
ProtClustDBPRK02106.

Enzyme and pathway databases

BioCycSEPI176280:SE_2165-MONOMER.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
KOK00108.
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. BetA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_STAES
AccessionPrimary (citable) accession number: Q8CMY2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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