Q8CMW2 (OTCC2_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase 2, catabolic
Short name=OTCase 2
EC=2.1.3.3

Gene names

Name:	arcB2
Ordered Locus Names:	SE_2216

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Ornithine carbamoyltransferase 2, catabolic HAMAP MF_01109		PRO_0000113024
Regions
	Region	62 – 66	5	Carbamoyl phosphate binding By similarity
	Region	276 – 279	4	Ornithine binding By similarity
Sites
	Binding site	113	1	Carbamoyl phosphate By similarity
	Binding site	140	1	Carbamoyl phosphate By similarity
	Site	37	1	Important for structural integrity By similarity
	Site	153	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CMW2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A16866BA497750EF	FASTA	335	37,852
	10 20 30 40 50 60 MKNIKKPFDL KGKSLLKEYD LTGEEFEGLI DFAMTLKKYK QQGTPHRYLE GKNIALLFEK 70 80 90 100 110 120 TSTRTRAAFT VASIDLGAHP EFLGKNDIQL GKKESVEDTA KVLGRMFDGI EFRGFSQKTV 130 140 150 160 170 180 EQLAEFSGVP VWNGLTDDWH PTQMLADYMT IKENFGYLKG INLTYVGNGR NNVAHSLMVA 190 200 210 220 230 240 GAMLGVNVRI CTPSSLTPRD VYFNIAKDQA SNYGGSVKIT DNIHTAVKDA DVIYTDVWVS 250 260 270 280 290 300 MGEESEFETR IHLLKDYQVN RKMLNLTGKV DTIFLHCLPA FHDTQTEYGQ DIFKKYGLTE 310 320 330 MEVTDEIFRS EHSRVFDQAE NRMHTIKAVM AATLG

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO05858.1.
RefSeq	NP_765771.1. NC_004461.1.
3D structure databases
ProteinModelPortal	Q8CMW2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CMW2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000039529; EBSTAP00000038162; EBSTAG00000039527.
GeneID	1056497.
GenomeReviews	Gene locus SE_2216 in contig AE015929_GR.
KEGG	sep:SE2216.
PATRIC	19610286. VBIStaEpi113981_2163.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
GeneTree	EBGT00050000023906.
HOGENOM	HBG579429.
OMA	VRICTPE.
PhylomeDB	Q8CMW2.
ProtClustDB	PRK02102.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_2216-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC2_STAES

Accession

Primary (citable) accession number: Q8CMW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program