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Q8CMT7

- DHPS_STAES

UniProt

Q8CMT7 - DHPS_STAES

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Protein

Dihydropteroate synthase

Gene

folP

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111MagnesiumBy similarity
Binding sitei19 – 191SubstrateBy similarity
Binding sitei89 – 891SubstrateBy similarity
Binding sitei108 – 1081SubstrateBy similarity
Binding sitei172 – 1721SubstrateBy similarity
Binding sitei208 – 2081SubstrateBy similarity
Binding sitei244 – 2441SubstrateBy similarity
Binding sitei246 – 2461SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-2338-MONOMER.
UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Ordered Locus Names:SE_2269
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Dihydropteroate synthasePRO_0000168227Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi176280.SE2269.

Structurei

3D structure databases

ProteinModelPortaliQ8CMT7.
SMRiQ8CMT7. Positions 3-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 256256Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 522Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
KOiK00796.
OMAiDMFYVAA.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CMT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKTKIMGIL NVTPDSFSDG GQYHSVDQAV KRAKEMIDEG VDIIDVGGVS
60 70 80 90 100
TRPGHKEVSH KEVSLKEEMN RVLPVVESIV KYDVQISVDT FRSEVAEACL
110 120 130 140 150
KLGVSMINDQ WAGLFDSNMF NVVSQYGAEI VLTHNGDGHR DKPVVEEMLV
160 170 180 190 200
SLLAQANKAE LAGIPHNKIW LDPGIGFPKT REEENEVMAR LDELVATEYP
210 220 230 240 250
VLLATSRKRY IKEMMNQDSS PSDRDEATAA TTAYGIMKGV RGVRVHNVLL
260 270
NTRLAQSMDF LKENEYERHH LS
Length:272
Mass (Da):30,369
Last modified:March 1, 2003 - v1
Checksum:i4194EFA5097F34B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05911.1.
RefSeqiNP_765824.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05911; AAO05911; SE_2269.
GeneIDi1057452.
KEGGisep:SE2269.
PATRICi19610410. VBIStaEpi113981_2212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05911.1 .
RefSeqi NP_765824.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CMT7.
SMRi Q8CMT7. Positions 3-270.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE2269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO05911 ; AAO05911 ; SE_2269 .
GeneIDi 1057452.
KEGGi sep:SE2269.
PATRICi 19610410. VBIStaEpi113981_2212.

Phylogenomic databases

eggNOGi COG0294.
KOi K00796.
OMAi DMFYVAA.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .
BioCyci SEPI176280:GCDG-2338-MONOMER.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiDHPS_STAES
AccessioniPrimary (citable) accession number: Q8CMT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3