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Q8CMP4

- SDRF_STAES

UniProt

Q8CMP4 - SDRF_STAES

Protein

Serine-aspartate repeat-containing protein F

Gene

sdrF

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Binds to type I collagen via alpha-2(I) or alpha-1(I) chains.By similarity

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-2468-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine-aspartate repeat-containing protein F
    Gene namesi
    Name:sdrF
    Ordered Locus Names:SE_2395
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    Subcellular locationi

    Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4545Sequence AnalysisAdd
    BLAST
    Chaini46 – 15971552Serine-aspartate repeat-containing protein FPRO_0000304881Add
    BLAST
    Propeptidei1598 – 163336Removed by sortasePROSITE-ProRule annotationPRO_0000304882Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1597 – 15971Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE2395.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CMP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini679 – 797119CNA-B 1Add
    BLAST
    Domaini798 – 907110CNA-B 2Add
    BLAST
    Domaini908 – 1018111CNA-B 3Add
    BLAST
    Domaini1019 – 1129111CNA-B 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni46 – 678633Ligand binding A regionAdd
    BLAST
    Regioni679 – 1129451Type I collagen binding regionBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1594 – 15985LPXTG sorting signalPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1130 – 1587458Asp/Ser-richAdd
    BLAST

    Domaini

    Each CNA-B domain is able to independently mediate adherence to the substrate.By similarity

    Sequence similaritiesi

    Contains 4 CNA-B domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    OMAiVTDITFQ.
    OrthoDBiEOG6PKF9Z.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    2.60.40.1280. 1 hit.
    InterProiIPR008966. Adhesion_dom.
    IPR008454. Collagen-bd_Cna-like_B-typ_dom.
    IPR011252. Fibrogen-bd_dom1.
    IPR019948. Gram-positive_anchor.
    IPR013783. Ig-like_fold.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PfamiPF05738. Cna_B. 4 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view]
    SUPFAMiSSF49401. SSF49401. 2 hits.
    TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CMP4-1 [UniParc]FASTAAdd to Basket

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    MKKRRQGPIN KRVDFLSNKV NKYSIRKFTV GTASILVGAT LMFGAADNEA     50
    KAAEDNQLES ASKEEQKGSR DNESSKLNQV DLDNGSHSSE KTTNVNNATE 100
    VKKVEAPTTS DVSKPKANEA VVTNESTKPK TTEAPTVNEE SIAETPKTST 150
    TQQDSTEKNN PSLKDNLNSS STTSKESKTD EHSTKQAQMS TNKSNLDTND 200
    SPTQSEKTSS QANNDSTDNQ SAPSKQLDSK PSEQKVYKTK FNDEPTQDVE 250
    HTTTKLKTPS ISTDSSVNDK QDYTRSAVAS LGVDSNETEA ITNAVRDNLD 300
    LKAASREQIN EAIIAEALKK DFSNPDYGVD TPLALNTSQS KNSPHKSASP 350
    RMNLMSLAAE PNSGKNVNDK VKITNPTLSL NKSNNHANNV IWPTSNEQFN 400
    LKANYELDDS IKEGDTFTIK YGQYIRPGGL ELPAIKTQLR SKDGSIVANG 450
    VYDKTTNTTT YTFTNYVDQY QNITGSFDLI ATPKRETAIK DNQNYPMEVT 500
    IANEVVKKDF IVDYGNKKDN TTTAAVANVD NVNNKHNEVV YLNQNNQNPK 550
    YAKYFSTVKN GKFIPGEVKV YEVTDTNAMV DSFNPDLNSS NVKDVTSQFT 600
    PKVSADGTRV DINFARSMAN GKKYIVTQAV RPTGTGNVYT EYWLTRDGTT 650
    NTNDFYRGTK STTVTYLNGS STAQGDNPTY SLGDYVWLDK NKNGVQDDDE 700
    KGLAGVYVTL KDSNNRELQR VTTDQSGHYQ FDNLQNGTYT VEFAIPDNYT 750
    PSPANNSTND AIDSDGERDG TRKVVVAKGT INNADNMTVD TGFYLTPKYN 800
    VGDYVWEDTN KDGIQDDNEK GISNVKVTLK NKNGDTIGTT TTDSNGKYEF 850
    TGLENGDYTI EFETPEGYTP TKQNSGSDEG KDSNGTKTTV TVKDADNKTI 900
    DSGFYKPIYN LGDYVWEDTN KDGIQDDSEK GISGVKVTLK DKNGNAIGTT 950
    TTDASGHYQF KGLENGSYTV EFETPSGYTP TKANSGQDIT VDSNGITTTG 1000
    IINGADNLTI DSGFYKTPKY SVGDYVWEDT NKDGIQDDNE KGISGVKVTL 1050
    KDEKGNIIST TTTDENGKYQ FDNLDSGNYI IHFEKPEGMT QTTANSGNDD 1100
    EKDADGEDVR VTITDHDDFS IDNGYFDDDS DSDSDADSDS DSDSDSDADS 1150
    DSDADSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDADSDS DADSDSDSDS 1200
    DSDSDSDSDS DSDSDSDSDS DSDADSDSDA DSDSDADSDS DADSDSDSDS 1250
    DSDADSDSDS DSDSDADSDS DSDSDSDADS DSDSDSDSDA DSDSDSDSDS 1300
    DADSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDADSDS 1350
    DSDSDSDADS DSDADSDSDS DSDSDSDSDS DADSDSDSDS DSDSDSDSDA 1400
    DSDSDSDSDS DAESDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDADS 1450
    DSDSDSDSDS DSDSDSDSDS DSDSDSDADS DSYSDSDSDS DSDSDSDSDS 1500
    DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS 1550
    DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDKNA KDKLPDTGAN 1600
    EDHDSKGTLL GTLFAGLGAL LLGRRRKKDN KEK 1633
    Length:1,633
    Mass (Da):174,771
    Last modified:March 1, 2003 - v1
    Checksum:iDAA8537B8CD288BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO06038.1.
    RefSeqiNP_765950.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO06038; AAO06038; SE_2395.
    GeneIDi1057120.
    KEGGisep:SE2395.
    PATRICi19610664. VBIStaEpi113981_2335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO06038.1 .
    RefSeqi NP_765950.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CMP4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE2395.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO06038 ; AAO06038 ; SE_2395 .
    GeneIDi 1057120.
    KEGGi sep:SE2395.
    PATRICi 19610664. VBIStaEpi113981_2335.

    Phylogenomic databases

    eggNOGi NOG12793.
    OMAi VTDITFQ.
    OrthoDBi EOG6PKF9Z.

    Enzyme and pathway databases

    BioCyci SEPI176280:GCDG-2468-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    2.60.40.1280. 1 hit.
    InterProi IPR008966. Adhesion_dom.
    IPR008454. Collagen-bd_Cna-like_B-typ_dom.
    IPR011252. Fibrogen-bd_dom1.
    IPR019948. Gram-positive_anchor.
    IPR013783. Ig-like_fold.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    Pfami PF05738. Cna_B. 4 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49401. SSF49401. 2 hits.
    TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiSDRF_STAES
    AccessioniPrimary (citable) accession number: Q8CMP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3