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Q8CMP4

- SDRF_STAES

UniProt

Q8CMP4 - SDRF_STAES

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Protein

Serine-aspartate repeat-containing protein F

Gene

sdrF

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Binds to type I collagen via alpha-2(I) or alpha-1(I) chains.By similarity

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-2468-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-aspartate repeat-containing protein F
Gene namesi
Name:sdrF
Ordered Locus Names:SE_2395
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

Subcellular locationi

Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4545Sequence AnalysisAdd
BLAST
Chaini46 – 15971552Serine-aspartate repeat-containing protein FPRO_0000304881Add
BLAST
Propeptidei1598 – 163336Removed by sortasePROSITE-ProRule annotationPRO_0000304882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1597 – 15971Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2395.

Structurei

3D structure databases

ProteinModelPortaliQ8CMP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini679 – 797119CNA-B 1Add
BLAST
Domaini798 – 907110CNA-B 2Add
BLAST
Domaini908 – 1018111CNA-B 3Add
BLAST
Domaini1019 – 1129111CNA-B 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 678633Ligand binding A regionAdd
BLAST
Regioni679 – 1129451Type I collagen binding regionBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1594 – 15985LPXTG sorting signalPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1130 – 1587458Asp/Ser-richAdd
BLAST

Domaini

Each CNA-B domain is able to independently mediate adherence to the substrate.By similarity

Sequence similaritiesi

Contains 4 CNA-B domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
OMAiVTDITFQ.
OrthoDBiEOG6PKF9Z.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
2.60.40.1280. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR011252. Fibrogen-bd_dom1.
IPR019948. Gram-positive_anchor.
IPR013783. Ig-like_fold.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF05738. Cna_B. 4 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CMP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKRRQGPIN KRVDFLSNKV NKYSIRKFTV GTASILVGAT LMFGAADNEA
60 70 80 90 100
KAAEDNQLES ASKEEQKGSR DNESSKLNQV DLDNGSHSSE KTTNVNNATE
110 120 130 140 150
VKKVEAPTTS DVSKPKANEA VVTNESTKPK TTEAPTVNEE SIAETPKTST
160 170 180 190 200
TQQDSTEKNN PSLKDNLNSS STTSKESKTD EHSTKQAQMS TNKSNLDTND
210 220 230 240 250
SPTQSEKTSS QANNDSTDNQ SAPSKQLDSK PSEQKVYKTK FNDEPTQDVE
260 270 280 290 300
HTTTKLKTPS ISTDSSVNDK QDYTRSAVAS LGVDSNETEA ITNAVRDNLD
310 320 330 340 350
LKAASREQIN EAIIAEALKK DFSNPDYGVD TPLALNTSQS KNSPHKSASP
360 370 380 390 400
RMNLMSLAAE PNSGKNVNDK VKITNPTLSL NKSNNHANNV IWPTSNEQFN
410 420 430 440 450
LKANYELDDS IKEGDTFTIK YGQYIRPGGL ELPAIKTQLR SKDGSIVANG
460 470 480 490 500
VYDKTTNTTT YTFTNYVDQY QNITGSFDLI ATPKRETAIK DNQNYPMEVT
510 520 530 540 550
IANEVVKKDF IVDYGNKKDN TTTAAVANVD NVNNKHNEVV YLNQNNQNPK
560 570 580 590 600
YAKYFSTVKN GKFIPGEVKV YEVTDTNAMV DSFNPDLNSS NVKDVTSQFT
610 620 630 640 650
PKVSADGTRV DINFARSMAN GKKYIVTQAV RPTGTGNVYT EYWLTRDGTT
660 670 680 690 700
NTNDFYRGTK STTVTYLNGS STAQGDNPTY SLGDYVWLDK NKNGVQDDDE
710 720 730 740 750
KGLAGVYVTL KDSNNRELQR VTTDQSGHYQ FDNLQNGTYT VEFAIPDNYT
760 770 780 790 800
PSPANNSTND AIDSDGERDG TRKVVVAKGT INNADNMTVD TGFYLTPKYN
810 820 830 840 850
VGDYVWEDTN KDGIQDDNEK GISNVKVTLK NKNGDTIGTT TTDSNGKYEF
860 870 880 890 900
TGLENGDYTI EFETPEGYTP TKQNSGSDEG KDSNGTKTTV TVKDADNKTI
910 920 930 940 950
DSGFYKPIYN LGDYVWEDTN KDGIQDDSEK GISGVKVTLK DKNGNAIGTT
960 970 980 990 1000
TTDASGHYQF KGLENGSYTV EFETPSGYTP TKANSGQDIT VDSNGITTTG
1010 1020 1030 1040 1050
IINGADNLTI DSGFYKTPKY SVGDYVWEDT NKDGIQDDNE KGISGVKVTL
1060 1070 1080 1090 1100
KDEKGNIIST TTTDENGKYQ FDNLDSGNYI IHFEKPEGMT QTTANSGNDD
1110 1120 1130 1140 1150
EKDADGEDVR VTITDHDDFS IDNGYFDDDS DSDSDADSDS DSDSDSDADS
1160 1170 1180 1190 1200
DSDADSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDADSDS DADSDSDSDS
1210 1220 1230 1240 1250
DSDSDSDSDS DSDSDSDSDS DSDADSDSDA DSDSDADSDS DADSDSDSDS
1260 1270 1280 1290 1300
DSDADSDSDS DSDSDADSDS DSDSDSDADS DSDSDSDSDA DSDSDSDSDS
1310 1320 1330 1340 1350
DADSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDADSDS
1360 1370 1380 1390 1400
DSDSDSDADS DSDADSDSDS DSDSDSDSDS DADSDSDSDS DSDSDSDSDA
1410 1420 1430 1440 1450
DSDSDSDSDS DAESDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDADS
1460 1470 1480 1490 1500
DSDSDSDSDS DSDSDSDSDS DSDSDSDADS DSYSDSDSDS DSDSDSDSDS
1510 1520 1530 1540 1550
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS
1560 1570 1580 1590 1600
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDKNA KDKLPDTGAN
1610 1620 1630
EDHDSKGTLL GTLFAGLGAL LLGRRRKKDN KEK
Length:1,633
Mass (Da):174,771
Last modified:March 1, 2003 - v1
Checksum:iDAA8537B8CD288BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO06038.1.
RefSeqiNP_765950.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO06038; AAO06038; SE_2395.
GeneIDi1057120.
KEGGisep:SE2395.
PATRICi19610664. VBIStaEpi113981_2335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO06038.1 .
RefSeqi NP_765950.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CMP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE2395.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO06038 ; AAO06038 ; SE_2395 .
GeneIDi 1057120.
KEGGi sep:SE2395.
PATRICi 19610664. VBIStaEpi113981_2335.

Phylogenomic databases

eggNOGi NOG12793.
OMAi VTDITFQ.
OrthoDBi EOG6PKF9Z.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-2468-MONOMER.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
2.60.40.1280. 1 hit.
InterProi IPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR011252. Fibrogen-bd_dom1.
IPR019948. Gram-positive_anchor.
IPR013783. Ig-like_fold.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF05738. Cna_B. 4 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view ]
SUPFAMi SSF49401. SSF49401. 2 hits.
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiSDRF_STAES
AccessioniPrimary (citable) accession number: Q8CMP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3