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Q8CMP4 (SDRF_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine-aspartate repeat-containing protein F
Gene names
Name:sdrF
Ordered Locus Names:SE_2395
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length1633 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Binds to type I collagen via alpha-2(I) or alpha-1(I) chains By similarity.

Subcellular location

Secreted › cell wall; Peptidoglycan-anchor Potential.

Domain

Each CNA-B domain is able to independently mediate adherence to the substrate By similarity.

Sequence similarities

Belongs to the serine-aspartate repeat-containing protein (SDr) family.

Contains 4 CNA-B domains.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell wall
Secreted
   DomainRepeat
Signal
   PTMPeptidoglycan-anchor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4545 Potential
Chain46 – 15971552Serine-aspartate repeat-containing protein F
PRO_0000304881
Propeptide1598 – 163336Removed by sortase Potential
PRO_0000304882

Regions

Domain679 – 797119CNA-B 1
Domain798 – 907110CNA-B 2
Domain908 – 1018111CNA-B 3
Domain1019 – 1129111CNA-B 4
Region46 – 678633Ligand binding A region
Region679 – 1129451Type I collagen binding region By similarity
Motif1594 – 15985LPXTG sorting signal Potential
Compositional bias1130 – 1587458Asp/Ser-rich

Amino acid modifications

Modified residue15971Pentaglycyl murein peptidoglycan amidated threonine Potential

Sequences

Sequence LengthMass (Da)Tools
Q8CMP4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: DAA8537B8CD288BD

FASTA1,633174,771
        10         20         30         40         50         60 
MKKRRQGPIN KRVDFLSNKV NKYSIRKFTV GTASILVGAT LMFGAADNEA KAAEDNQLES 

        70         80         90        100        110        120 
ASKEEQKGSR DNESSKLNQV DLDNGSHSSE KTTNVNNATE VKKVEAPTTS DVSKPKANEA 

       130        140        150        160        170        180 
VVTNESTKPK TTEAPTVNEE SIAETPKTST TQQDSTEKNN PSLKDNLNSS STTSKESKTD 

       190        200        210        220        230        240 
EHSTKQAQMS TNKSNLDTND SPTQSEKTSS QANNDSTDNQ SAPSKQLDSK PSEQKVYKTK 

       250        260        270        280        290        300 
FNDEPTQDVE HTTTKLKTPS ISTDSSVNDK QDYTRSAVAS LGVDSNETEA ITNAVRDNLD 

       310        320        330        340        350        360 
LKAASREQIN EAIIAEALKK DFSNPDYGVD TPLALNTSQS KNSPHKSASP RMNLMSLAAE 

       370        380        390        400        410        420 
PNSGKNVNDK VKITNPTLSL NKSNNHANNV IWPTSNEQFN LKANYELDDS IKEGDTFTIK 

       430        440        450        460        470        480 
YGQYIRPGGL ELPAIKTQLR SKDGSIVANG VYDKTTNTTT YTFTNYVDQY QNITGSFDLI 

       490        500        510        520        530        540 
ATPKRETAIK DNQNYPMEVT IANEVVKKDF IVDYGNKKDN TTTAAVANVD NVNNKHNEVV 

       550        560        570        580        590        600 
YLNQNNQNPK YAKYFSTVKN GKFIPGEVKV YEVTDTNAMV DSFNPDLNSS NVKDVTSQFT 

       610        620        630        640        650        660 
PKVSADGTRV DINFARSMAN GKKYIVTQAV RPTGTGNVYT EYWLTRDGTT NTNDFYRGTK 

       670        680        690        700        710        720 
STTVTYLNGS STAQGDNPTY SLGDYVWLDK NKNGVQDDDE KGLAGVYVTL KDSNNRELQR 

       730        740        750        760        770        780 
VTTDQSGHYQ FDNLQNGTYT VEFAIPDNYT PSPANNSTND AIDSDGERDG TRKVVVAKGT 

       790        800        810        820        830        840 
INNADNMTVD TGFYLTPKYN VGDYVWEDTN KDGIQDDNEK GISNVKVTLK NKNGDTIGTT 

       850        860        870        880        890        900 
TTDSNGKYEF TGLENGDYTI EFETPEGYTP TKQNSGSDEG KDSNGTKTTV TVKDADNKTI 

       910        920        930        940        950        960 
DSGFYKPIYN LGDYVWEDTN KDGIQDDSEK GISGVKVTLK DKNGNAIGTT TTDASGHYQF 

       970        980        990       1000       1010       1020 
KGLENGSYTV EFETPSGYTP TKANSGQDIT VDSNGITTTG IINGADNLTI DSGFYKTPKY 

      1030       1040       1050       1060       1070       1080 
SVGDYVWEDT NKDGIQDDNE KGISGVKVTL KDEKGNIIST TTTDENGKYQ FDNLDSGNYI 

      1090       1100       1110       1120       1130       1140 
IHFEKPEGMT QTTANSGNDD EKDADGEDVR VTITDHDDFS IDNGYFDDDS DSDSDADSDS 

      1150       1160       1170       1180       1190       1200 
DSDSDSDADS DSDADSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDADSDS DADSDSDSDS 

      1210       1220       1230       1240       1250       1260 
DSDSDSDSDS DSDSDSDSDS DSDADSDSDA DSDSDADSDS DADSDSDSDS DSDADSDSDS 

      1270       1280       1290       1300       1310       1320 
DSDSDADSDS DSDSDSDADS DSDSDSDSDA DSDSDSDSDS DADSDSDSDS DSDSDSDSDS 

      1330       1340       1350       1360       1370       1380 
DSDSDSDSDS DSDSDSDSDS DSDSDADSDS DSDSDSDADS DSDADSDSDS DSDSDSDSDS 

      1390       1400       1410       1420       1430       1440 
DADSDSDSDS DSDSDSDSDA DSDSDSDSDS DAESDSDSDS DSDSDSDSDS DSDSDSDSDS 

      1450       1460       1470       1480       1490       1500 
DSDSDSDADS DSDSDSDSDS DSDSDSDSDS DSDSDSDADS DSYSDSDSDS DSDSDSDSDS 

      1510       1520       1530       1540       1550       1560 
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS 

      1570       1580       1590       1600       1610       1620 
DSDSDSDSDS DSDSDSDSDS DSDSDSDKNA KDKLPDTGAN EDHDSKGTLL GTLFAGLGAL 

      1630 
LLGRRRKKDN KEK

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References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO06038.1.
RefSeqNP_765950.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CMP4.
ModBaseSearch...

Protein-protein interaction databases

STRING176280.SE2395.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO06038; AAO06038; SE_2395.
GeneID1057120.
KEGGsep:SE2395.
PATRIC19610664. VBIStaEpi113981_2335.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG12793.
OMAVTDITFQ.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
2.60.40.1280. 1 hit.
InterProIPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR011252. Fibrogen-bd_dom1.
IPR005877. Gpos_YSIRK.
IPR019948. Gram-positive_anchor.
IPR013783. Ig-like_fold.
IPR019931. LPXTG-motif_cell_wall_anchor.
[Graphical view]
PfamPF05738. Cna_B. 4 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMSSF49401. Adhes_bact. 2 hits.
TIGRFAMsTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDRF_STAES
AccessionPrimary (citable) accession number: Q8CMP4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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