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Q8CMN2

- SLE1_STAES

UniProt

Q8CMN2 - SLE1_STAES

Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. barrier septum assembly Source: UniProtKB-KW
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

    Enzyme and pathway databases

    BioCyciSEPI176280:GCDG-2392-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
    Gene namesi
    Name:sle1
    Synonyms:aaa
    Ordered Locus Names:SE_2319
    OrganismiStaphylococcus epidermidis (strain ATCC 12228)
    Taxonomic identifieri176280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001411: Chromosome

    Subcellular locationi

    Secreted By similarity. Cell surface By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 324299N-acetylmuramoyl-L-alanine amidase sle1PRO_0000231628Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176280.SE2319.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CMN2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 7143LysM 1Add
    BLAST
    Repeati86 – 12843LysM 2Add
    BLAST
    Repeati149 – 19143LysM 3Add
    BLAST
    Domaini200 – 324125Peptidase C51PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 LysM repeats.Curated
    Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG3942.
    OMAiEMNYSAS.
    OrthoDBiEOG6GTZPF.

    Family and domain databases

    Gene3Di3.10.350.10. 3 hits.
    InterProiIPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view]
    PfamiPF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view]
    SMARTiSM00257. LysM. 3 hits.
    [Graphical view]
    SUPFAMiSSF54106. SSF54106. 3 hits.
    PROSITEiPS50911. CHAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CMN2-1 [UniParc]FASTAAdd to Basket

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    MQKKYITAII GTTALSALAS THAQAATTHT VKSGESVWSI SHKYGISIAK    50
    LKSLNGLTSN LIFPNQVLKV SGSSSRATST NSGTVYTVKA GDSLSSIAAK 100
    YGTTYQKIMQ LNGLNNYLIF PGQKLKVSGK ATSSSRAKAS GSSGRTATYT 150
    VKYGDSLSAI ASKYGTTYQK IMQLNGLTNF FIYPGQKLKV PGGSSSSSSS 200
    NNTRSNGGYY SPTFNHQNLY TWGQCTWHVF NRRAEIGKGI STYWWNANNW 250
    DNASAADGYT IDYRPTVGSI AQTDAGYYGH VAFVERVNSD GSILVSEMNW 300
    SAAPGNMTYR TIPAYQVRNY KFIH 324
    Length:324
    Mass (Da):35,075
    Last modified:March 1, 2003 - v1
    Checksum:iAE24C366090455F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05961.1.
    RefSeqiNP_765874.1. NC_004461.1.

    Genome annotation databases

    EnsemblBacteriaiAAO05961; AAO05961; SE_2319.
    GeneIDi1057712.
    KEGGisep:SE2319.
    PATRICi19610518. VBIStaEpi113981_2262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015929 Genomic DNA. Translation: AAO05961.1 .
    RefSeqi NP_765874.1. NC_004461.1.

    3D structure databases

    ProteinModelPortali Q8CMN2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176280.SE2319.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO05961 ; AAO05961 ; SE_2319 .
    GeneIDi 1057712.
    KEGGi sep:SE2319.
    PATRICi 19610518. VBIStaEpi113981_2262.

    Phylogenomic databases

    eggNOGi COG3942.
    OMAi EMNYSAS.
    OrthoDBi EOG6GTZPF.

    Enzyme and pathway databases

    BioCyci SEPI176280:GCDG-2392-MONOMER.

    Family and domain databases

    Gene3Di 3.10.350.10. 3 hits.
    InterProi IPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view ]
    Pfami PF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view ]
    SMARTi SM00257. LysM. 3 hits.
    [Graphical view ]
    SUPFAMi SSF54106. SSF54106. 3 hits.
    PROSITEi PS50911. CHAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
      Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
      Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12228.

    Entry informationi

    Entry nameiSLE1_STAES
    AccessioniPrimary (citable) accession number: Q8CMN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3