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Q8CMN2

- SLE1_STAES

UniProt

Q8CMN2 - SLE1_STAES

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Protein
N-acetylmuramoyl-L-alanine amidase sle1
Gene
sle1, aaa, SE_2319
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-2392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SE_2319
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

Subcellular locationi

Secreted By similarity. Cell surface By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 324299N-acetylmuramoyl-L-alanine amidase sle1
PRO_0000231628Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2319.

Structurei

3D structure databases

ProteinModelPortaliQ8CMN2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 7143LysM 1
Add
BLAST
Repeati86 – 12843LysM 2
Add
BLAST
Repeati149 – 19143LysM 3
Add
BLAST
Domaini200 – 324125Peptidase C51
Add
BLAST

Sequence similaritiesi

Contains 3 LysM repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3942.
OMAiEMNYSAS.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CMN2-1 [UniParc]FASTAAdd to Basket

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MQKKYITAII GTTALSALAS THAQAATTHT VKSGESVWSI SHKYGISIAK    50
LKSLNGLTSN LIFPNQVLKV SGSSSRATST NSGTVYTVKA GDSLSSIAAK 100
YGTTYQKIMQ LNGLNNYLIF PGQKLKVSGK ATSSSRAKAS GSSGRTATYT 150
VKYGDSLSAI ASKYGTTYQK IMQLNGLTNF FIYPGQKLKV PGGSSSSSSS 200
NNTRSNGGYY SPTFNHQNLY TWGQCTWHVF NRRAEIGKGI STYWWNANNW 250
DNASAADGYT IDYRPTVGSI AQTDAGYYGH VAFVERVNSD GSILVSEMNW 300
SAAPGNMTYR TIPAYQVRNY KFIH 324
Length:324
Mass (Da):35,075
Last modified:March 1, 2003 - v1
Checksum:iAE24C366090455F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05961.1.
RefSeqiNP_765874.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05961; AAO05961; SE_2319.
GeneIDi1057712.
KEGGisep:SE2319.
PATRICi19610518. VBIStaEpi113981_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015929 Genomic DNA. Translation: AAO05961.1 .
RefSeqi NP_765874.1. NC_004461.1.

3D structure databases

ProteinModelPortali Q8CMN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE2319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO05961 ; AAO05961 ; SE_2319 .
GeneIDi 1057712.
KEGGi sep:SE2319.
PATRICi 19610518. VBIStaEpi113981_2262.

Phylogenomic databases

eggNOGi COG3942.
OMAi EMNYSAS.
OrthoDBi EOG6GTZPF.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-2392-MONOMER.

Family and domain databases

Gene3Di 3.10.350.10. 3 hits.
InterProi IPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view ]
Pfami PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view ]
SMARTi SM00257. LysM. 3 hits.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 3 hits.
PROSITEi PS50911. CHAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiSLE1_STAES
AccessioniPrimary (citable) accession number: Q8CMN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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