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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SE_2319
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023162826 – 324N-acetylmuramoyl-L-alanine amidase sle1Add BLAST299

Proteomic databases

PRIDEiQ8CMN2.

Structurei

3D structure databases

ProteinModelPortaliQ8CMN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 70LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini84 – 127LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini147 – 190LysM 3PROSITE-ProRule annotationAdd BLAST44
Domaini200 – 324Peptidase C51PROSITE-ProRule annotationAdd BLAST125

Sequence similaritiesi

Contains 3 LysM domains.PROSITE-ProRule annotation
Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG41068JE. Bacteria.
COG1388. LUCA.
COG3942. LUCA.
OMAiNTPVFNH.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
PS51782. LYSM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CMN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKYITAII GTTALSALAS THAQAATTHT VKSGESVWSI SHKYGISIAK
60 70 80 90 100
LKSLNGLTSN LIFPNQVLKV SGSSSRATST NSGTVYTVKA GDSLSSIAAK
110 120 130 140 150
YGTTYQKIMQ LNGLNNYLIF PGQKLKVSGK ATSSSRAKAS GSSGRTATYT
160 170 180 190 200
VKYGDSLSAI ASKYGTTYQK IMQLNGLTNF FIYPGQKLKV PGGSSSSSSS
210 220 230 240 250
NNTRSNGGYY SPTFNHQNLY TWGQCTWHVF NRRAEIGKGI STYWWNANNW
260 270 280 290 300
DNASAADGYT IDYRPTVGSI AQTDAGYYGH VAFVERVNSD GSILVSEMNW
310 320
SAAPGNMTYR TIPAYQVRNY KFIH
Length:324
Mass (Da):35,075
Last modified:March 1, 2003 - v1
Checksum:iAE24C366090455F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05961.1.
RefSeqiNP_765874.1. NC_004461.1.
WP_001829380.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05961; AAO05961; SE_2319.
GeneIDi1057712.
KEGGisep:SE2319.
PATRICi19610518. VBIStaEpi113981_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05961.1.
RefSeqiNP_765874.1. NC_004461.1.
WP_001829380.1. NC_004461.1.

3D structure databases

ProteinModelPortaliQ8CMN2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.

Proteomic databases

PRIDEiQ8CMN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO05961; AAO05961; SE_2319.
GeneIDi1057712.
KEGGisep:SE2319.
PATRICi19610518. VBIStaEpi113981_2262.

Phylogenomic databases

eggNOGiENOG41068JE. Bacteria.
COG1388. LUCA.
COG3942. LUCA.
OMAiNTPVFNH.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
PS51782. LYSM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLE1_STAES
AccessioniPrimary (citable) accession number: Q8CMN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.