N-acetylmuramoyl-L-alanine amidase sle1 precursor - Staphylococcus epidermidis (strain ATCC 12228)

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Reviewed, UniProtKB/Swiss-Prot Q8CMN2 (SLE1_STAES)

Last modified January 19, 2010. Version 44. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1
EC=3.5.1.28

Gene names

Name:	sle1
Synonyms:	aaa
Ordered Locus Names:	SE_2319

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.
Catalytic activity	Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
Subcellular location	Secreted By similarity. Cell surface By similarity.
Sequence similarities	Contains 3 LysM repeats. Contains 1 peptidase C51 domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell wall biogenesis/degradation Septation Virulence
Cellular component	Secreted
Domain	Repeat Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	barrier septum formation Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell surface Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

25

Potential

Chain

299

N-acetylmuramoyl-L-alanine amidase sle1

PRO_0000231628

Regions

Repeat

43

LysM 1

Repeat

43

LysM 2

Repeat

43

LysM 3

Domain

125

Peptidase C51

Sequences

Sequence

Length

Mass (Da)

Tools

Q8CMN2-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: AE24C366090455F8
Show »

324

35,075

        10         20         30         40         50         60 
MQKKYITAII GTTALSALAS THAQAATTHT VKSGESVWSI SHKYGISIAK LKSLNGLTSN 

        70         80         90        100        110        120 
LIFPNQVLKV SGSSSRATST NSGTVYTVKA GDSLSSIAAK YGTTYQKIMQ LNGLNNYLIF 

       130        140        150        160        170        180 
PGQKLKVSGK ATSSSRAKAS GSSGRTATYT VKYGDSLSAI ASKYGTTYQK IMQLNGLTNF 

       190        200        210        220        230        240 
FIYPGQKLKV PGGSSSSSSS NNTRSNGGYY SPTFNHQNLY TWGQCTWHVF NRRAEIGKGI 

       250        260        270        280        290        300 
STYWWNANNW DNASAADGYT IDYRPTVGSI AQTDAGYYGH VAFVERVNSD GSILVSEMNW 

       310        320 
SAAPGNMTYR TIPAYQVRNY KFIH

References

[1]

"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015929 Genomic DNA. Translation: AAO05961.1.
RefSeq	NP_765874.1.
3D structure databases
SMR	Q8CMN2. Positions 27-72, 71-132, 85-179, 147-194, 211-324.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CMN2.
Genome annotation databases
GeneID	1057712.
GenomeReviews	Gene locus SE_2319 in contig AE015929_GR.
KEGG	sep:SE2319.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1388.
HOGENOM	HBG697363.
OMA	FNIYPGQ.
Enzyme and pathway databases
BioCyc	SEPI176280:SE_2319-MONOMER.
Family and domain databases
InterPro	IPR007921. CHAP. IPR018392. Peptidoglycan-bd_lysin. IPR002482. Peptidoglycan-bd_Lysin_sg. [Graphical view]
Pfam	PF05257. CHAP. 1 hit. PF01476. LysM. 3 hits. [Graphical view]
SMART	SM00257. LysM. 3 hits. [Graphical view]
PROSITE	PS50911. CHAP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SLE1_STAES

Accession

Primary (citable) accession number: Q8CMN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2003
Last modified:	January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents