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Q8CMN2 (SLE1_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetylmuramoyl-L-alanine amidase sle1

EC=3.5.1.28
Gene names
Name:sle1
Synonyms:aaa
Ordered Locus Names:SE_2319
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Subcellular location

Secreted By similarity. Cell surface By similarity.

Sequence similarities

Contains 3 LysM repeats.

Contains 1 peptidase C51 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 324299N-acetylmuramoyl-L-alanine amidase sle1
PRO_0000231628

Regions

Repeat29 – 7143LysM 1
Repeat86 – 12843LysM 2
Repeat149 – 19143LysM 3
Domain200 – 324125Peptidase C51

Sequences

Sequence LengthMass (Da)Tools
Q8CMN2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: AE24C366090455F8

FASTA32435,075
        10         20         30         40         50         60 
MQKKYITAII GTTALSALAS THAQAATTHT VKSGESVWSI SHKYGISIAK LKSLNGLTSN 

        70         80         90        100        110        120 
LIFPNQVLKV SGSSSRATST NSGTVYTVKA GDSLSSIAAK YGTTYQKIMQ LNGLNNYLIF 

       130        140        150        160        170        180 
PGQKLKVSGK ATSSSRAKAS GSSGRTATYT VKYGDSLSAI ASKYGTTYQK IMQLNGLTNF 

       190        200        210        220        230        240 
FIYPGQKLKV PGGSSSSSSS NNTRSNGGYY SPTFNHQNLY TWGQCTWHVF NRRAEIGKGI 

       250        260        270        280        290        300 
STYWWNANNW DNASAADGYT IDYRPTVGSI AQTDAGYYGH VAFVERVNSD GSILVSEMNW 

       310        320 
SAAPGNMTYR TIPAYQVRNY KFIH 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015929 Genomic DNA. Translation: AAO05961.1.
RefSeqNP_765874.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CMN2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE2319.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO05961; AAO05961; SE_2319.
GeneID1057712.
KEGGsep:SE2319.
PATRIC19610518. VBIStaEpi113981_2262.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3942.
OMAEMNYSAS.
OrthoDBEOG6GTZPF.
ProtClustDBCLSK884669.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-2392-MONOMER.

Family and domain databases

Gene3D3.10.350.10. 3 hits.
InterProIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMSSF54106. SSF54106. 3 hits.
PROSITEPS50911. CHAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSLE1_STAES
AccessionPrimary (citable) accession number: Q8CMN2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries