ID   ARCR_STAES              Reviewed;         228 AA.
AC   Q8CML2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 113.
DE   RecName: Full=HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=SE_2214;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC       under anaerobic conditions, thus playing an essential role in arginine
CC       catabolism. May also control the expression of genes encoding proteins
CC       which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AE015929; AAO05856.1; -; Genomic_DNA.
DR   RefSeq; NP_765769.1; NC_004461.1.
DR   RefSeq; WP_001831835.1; NZ_WBME01000025.1.
DR   AlphaFoldDB; Q8CML2; -.
DR   SMR; Q8CML2; -.
DR   DNASU; 1056495; -.
DR   GeneID; 50017717; -.
DR   KEGG; sep:SE_2214; -.
DR   PATRIC; fig|176280.10.peg.2161; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_1160528_0_0_9; -.
DR   OrthoDB; 2397993at2; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR24567; CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR24567:SF82; HTH-TYPE TRANSCRIPTIONAL REGULATOR ARCR; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..228
FT                   /note="HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000349418"
FT   DOMAIN          155..228
FT                   /note="HTH crp-type"
FT   DNA_BIND        188..207
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         22..141
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   228 AA;  26924 MW;  07370DBD75C1D475 CRC64;
     MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY YSSDETTHIY
     LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP NEMCTALTDC EMIGIPRDLI
     EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM ALTSKLAKER VTKILRYLCQ TVGYDHDEFY
     EIKHFMTIQL LSDMAGISRE TTSHIINELR EEKILFKNSK NWLVSKDL
//