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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 141cNMPAdd BLAST120
DNA bindingi188 – 207H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandcAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:SE_2214
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003494181 – 228HTH-type transcriptional regulator ArcRAdd BLAST228

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2214.

Structurei

3D structure databases

ProteinModelPortaliQ8CML2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 228HTH crp-typeAdd BLAST74

Phylogenomic databases

eggNOGiENOG4105IJS. Bacteria.
COG0664. LUCA.
KOiK21828.
OMAiEYLCKNH.

Family and domain databases

CDDicd00038. CAP_ED. 1 hit.
Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CML2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY
60 70 80 90 100
YSSDETTHIY LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP
110 120 130 140 150
NEMCTALTDC EMIGIPRDLI EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM
160 170 180 190 200
ALTSKLAKER VTKILRYLCQ TVGYDHDEFY EIKHFMTIQL LSDMAGISRE
210 220
TTSHIINELR EEKILFKNSK NWLVSKDL
Length:228
Mass (Da):26,924
Last modified:March 1, 2003 - v1
Checksum:i07370DBD75C1D475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05856.1.
RefSeqiNP_765769.1. NC_004461.1.
WP_001831835.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05856; AAO05856; SE_2214.
GeneIDi1056495.
KEGGisep:SE2214.
PATRICifig|176280.10.peg.2161.

Similar proteinsi

Entry informationi

Entry nameiARCR_STAES
AccessioniPrimary (citable) accession number: Q8CML2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome