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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 141cNMPAdd BLAST120
DNA bindingi188 – 207H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:SE_2214
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003494181 – 228HTH-type transcriptional regulator ArcRAdd BLAST228

Interactioni

Protein-protein interaction databases

STRINGi176280.SE2214.

Structurei

3D structure databases

ProteinModelPortaliQ8CML2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 228HTH crp-typeAdd BLAST74

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105IJS. Bacteria.
COG0664. LUCA.
OMAiEYLCKNH.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CML2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY
60 70 80 90 100
YSSDETTHIY LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP
110 120 130 140 150
NEMCTALTDC EMIGIPRDLI EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM
160 170 180 190 200
ALTSKLAKER VTKILRYLCQ TVGYDHDEFY EIKHFMTIQL LSDMAGISRE
210 220
TTSHIINELR EEKILFKNSK NWLVSKDL
Length:228
Mass (Da):26,924
Last modified:March 1, 2003 - v1
Checksum:i07370DBD75C1D475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05856.1.
RefSeqiNP_765769.1. NC_004461.1.
WP_001831835.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO05856; AAO05856; SE_2214.
GeneIDi1056495.
KEGGisep:SE2214.
PATRICi19610282. VBIStaEpi113981_2161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA. Translation: AAO05856.1.
RefSeqiNP_765769.1. NC_004461.1.
WP_001831835.1. NC_004461.1.

3D structure databases

ProteinModelPortaliQ8CML2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176280.SE2214.

Protocols and materials databases

DNASUi1056495.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO05856; AAO05856; SE_2214.
GeneIDi1056495.
KEGGisep:SE2214.
PATRICi19610282. VBIStaEpi113981_2161.

Phylogenomic databases

eggNOGiENOG4105IJS. Bacteria.
COG0664. LUCA.
OMAiEYLCKNH.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCR_STAES
AccessioniPrimary (citable) accession number: Q8CML2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.