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Q8CML2 (ARCR_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional regulator ArcR
Gene names
Name:arcR
Ordered Locus Names:SE_2214
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
   LigandcAMP
cAMP-binding
DNA-binding
Nucleotide-binding
   Molecular functionActivator
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

cAMP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228HTH-type transcriptional regulator ArcR
PRO_0000349418

Regions

Domain155 – 22874HTH crp-type
Nucleotide binding22 – 141120cNMP
DNA binding188 – 20720H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CML2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 07370DBD75C1D475

FASTA22826,924
        10         20         30         40         50         60 
MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY YSSDETTHIY 

        70         80         90        100        110        120 
LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP NEMCTALTDC EMIGIPRDLI 

       130        140        150        160        170        180 
EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM ALTSKLAKER VTKILRYLCQ TVGYDHDEFY 

       190        200        210        220 
EIKHFMTIQL LSDMAGISRE TTSHIINELR EEKILFKNSK NWLVSKDL 

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015929 Genomic DNA. Translation: AAO05856.1.
RefSeqNP_765769.1. NC_004461.1.

3D structure databases

ProteinModelPortalQ8CML2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE2214.

Protocols and materials databases

DNASU1056495.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO05856; AAO05856; SE_2214.
GeneID1056495.
KEGGsep:SE2214.
PATRIC19610282. VBIStaEpi113981_2161.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0664.
OMAERVNQNG.
OrthoDBEOG6QRWC5.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-2273-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARCR_STAES
AccessionPrimary (citable) accession number: Q8CML2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families