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Q8CJX0 (SYW1_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase 1

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase 1
Short name=TrpRS 1
Gene names
Name:trpS1
Ordered Locus Names:SCO3334
ORF Names:SCE68.32, SCE7.01
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Tryptophan--tRNA ligase 1 HAMAP-Rule MF_00140
PRO_0000136687

Regions

Motif10 – 189"HIGH" region HAMAP-Rule MF_00140
Motif197 – 2015"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2001ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CJX0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F109480ADFA00373

FASTA33636,804
        10         20         30         40         50         60 
MTRVFSGVKP TGHLTLGNYL GAMRRWAAVD QHRSDALFCV VDLHALTVDH DPARVRRLSR 

        70         80         90        100        110        120 
QAASLLLAAG LDPELCTVFV QSHVDEHARL SYVLECVATD GEMRRMIQYK EKAARERVRG 

       130        140        150        160        170        180 
GSVRLSLLTY PVLMAADILA YGTDEVPVGE DQTQHVELAR DLAVRFNQRY GHTFVVPRAT 

       190        200        210        220        230        240 
SPAVAARVMN LQEPASKMGK SDDTGPGIVY LLDEPDVVRK KVMRAVTDSG RDVVYDPEER 

       250        260        270        280        290        300 
AGLANLLEIL AACTDGEPAE LAGGYDSYGA LKKDTAEAVV EMLRPVRERH MELSADPGYV 

       310        320        330 
DGVLREGAEK ARAMARPTVD DAYRAIGLLP PVNAAR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939116 Genomic DNA. Translation: CAD55313.1.
PIRT36282.
RefSeqNP_733600.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ8CJX0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO3334.

Proteomic databases

PRIDEQ8CJX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD55313; CAD55313; CAD55313.
GeneID1098771.
KEGGsco:SCO3334.
PATRIC23736418. VBIStrCoe124346_3394.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAPELCTVF.
OrthoDBEOG686NJQ.
PhylomeDBQ8CJX0.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW1_STRCO
AccessionPrimary (citable) accession number: Q8CJX0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries