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Q8CJX0

- SYW1_STRCO

UniProt

Q8CJX0 - SYW1_STRCO

Protein

Tryptophan--tRNA ligase 1

Gene

trpS1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei200 – 2001ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase 1UniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase 1UniRule annotation
    Short name:
    TrpRS 1UniRule annotation
    Gene namesi
    Name:trpS1UniRule annotation
    Ordered Locus Names:SCO3334
    ORF Names:SCE68.32, SCE7.01
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Tryptophan--tRNA ligase 1PRO_0000136687Add
    BLAST

    Proteomic databases

    PRIDEiQ8CJX0.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi100226.SCO3334.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CJX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi10 – 189"HIGH" region
    Motifi197 – 2015"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059940.
    KOiK01867.
    OMAiPELCTVF.
    OrthoDBiEOG686NJQ.
    PhylomeDBiQ8CJX0.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CJX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRVFSGVKP TGHLTLGNYL GAMRRWAAVD QHRSDALFCV VDLHALTVDH    50
    DPARVRRLSR QAASLLLAAG LDPELCTVFV QSHVDEHARL SYVLECVATD 100
    GEMRRMIQYK EKAARERVRG GSVRLSLLTY PVLMAADILA YGTDEVPVGE 150
    DQTQHVELAR DLAVRFNQRY GHTFVVPRAT SPAVAARVMN LQEPASKMGK 200
    SDDTGPGIVY LLDEPDVVRK KVMRAVTDSG RDVVYDPEER AGLANLLEIL 250
    AACTDGEPAE LAGGYDSYGA LKKDTAEAVV EMLRPVRERH MELSADPGYV 300
    DGVLREGAEK ARAMARPTVD DAYRAIGLLP PVNAAR 336
    Length:336
    Mass (Da):36,804
    Last modified:March 1, 2003 - v1
    Checksum:iF109480ADFA00373
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939116 Genomic DNA. Translation: CAD55313.1.
    PIRiT36282.
    RefSeqiNP_733600.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAD55313; CAD55313; CAD55313.
    GeneIDi1098771.
    KEGGisco:SCO3334.
    PATRICi23736418. VBIStrCoe124346_3394.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939116 Genomic DNA. Translation: CAD55313.1 .
    PIRi T36282.
    RefSeqi NP_733600.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q8CJX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO3334.

    Proteomic databases

    PRIDEi Q8CJX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD55313 ; CAD55313 ; CAD55313 .
    GeneIDi 1098771.
    KEGGi sco:SCO3334.
    PATRICi 23736418. VBIStrCoe124346_3394.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059940.
    KOi K01867.
    OMAi PELCTVF.
    OrthoDBi EOG686NJQ.
    PhylomeDBi Q8CJX0.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiSYW1_STRCO
    AccessioniPrimary (citable) accession number: Q8CJX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3