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Protein

Tryptophan--tRNA ligase 1

Gene

trpS1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137L-tryptophanUniRule annotation1
Binding sitei188ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi149 – 151ATPUniRule annotation3
Nucleotide bindingi197 – 201ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.2 5998

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 1UniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetase 1UniRule annotation
Short name:
TrpRS 1UniRule annotation
Gene namesi
Name:trpS1UniRule annotation
Ordered Locus Names:SCO3334
ORF Names:SCE68.32, SCE7.01
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366871 – 336Tryptophan--tRNA ligase 1Add BLAST336

Proteomic databases

PRIDEiQ8CJX0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO3334

Structurei

3D structure databases

ProteinModelPortaliQ8CJX0
SMRiQ8CJX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi197 – 201"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
InParanoidiQ8CJX0
KOiK01867
OMAiRKDDPGH
OrthoDBiPOG091H00I9
PhylomeDBiQ8CJX0

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CJX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRVFSGVKP TGHLTLGNYL GAMRRWAAVD QHRSDALFCV VDLHALTVDH
60 70 80 90 100
DPARVRRLSR QAASLLLAAG LDPELCTVFV QSHVDEHARL SYVLECVATD
110 120 130 140 150
GEMRRMIQYK EKAARERVRG GSVRLSLLTY PVLMAADILA YGTDEVPVGE
160 170 180 190 200
DQTQHVELAR DLAVRFNQRY GHTFVVPRAT SPAVAARVMN LQEPASKMGK
210 220 230 240 250
SDDTGPGIVY LLDEPDVVRK KVMRAVTDSG RDVVYDPEER AGLANLLEIL
260 270 280 290 300
AACTDGEPAE LAGGYDSYGA LKKDTAEAVV EMLRPVRERH MELSADPGYV
310 320 330
DGVLREGAEK ARAMARPTVD DAYRAIGLLP PVNAAR
Length:336
Mass (Da):36,804
Last modified:March 1, 2003 - v1
Checksum:iF109480ADFA00373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA Translation: CAD55313.1
PIRiT36282
RefSeqiNP_733600.1, NC_003888.3
WP_003975499.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAD55313; CAD55313; CAD55313
GeneIDi1098771
KEGGisco:SCO3334
PATRICifig|100226.15.peg.3394

Similar proteinsi

Entry informationi

Entry nameiSYW1_STRCO
AccessioniPrimary (citable) accession number: Q8CJX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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