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Q8CJX0

- SYW1_STRCO

UniProt

Q8CJX0 - SYW1_STRCO

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Protein
Tryptophan--tRNA ligase 1
Gene
trpS1, SCO3334, SCE68.32, SCE7.01
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei200 – 2001ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 1 (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase 1
Short name:
TrpRS 1
Gene namesi
Name:trpS1
Ordered Locus Names:SCO3334
ORF Names:SCE68.32, SCE7.01
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Tryptophan--tRNA ligase 1UniRule annotation
PRO_0000136687Add
BLAST

Proteomic databases

PRIDEiQ8CJX0.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO3334.

Structurei

3D structure databases

ProteinModelPortaliQ8CJX0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi10 – 189"HIGH" regionUniRule annotation
Motifi197 – 2015"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiPELCTVF.
OrthoDBiEOG686NJQ.
PhylomeDBiQ8CJX0.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CJX0-1 [UniParc]FASTAAdd to Basket

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MTRVFSGVKP TGHLTLGNYL GAMRRWAAVD QHRSDALFCV VDLHALTVDH    50
DPARVRRLSR QAASLLLAAG LDPELCTVFV QSHVDEHARL SYVLECVATD 100
GEMRRMIQYK EKAARERVRG GSVRLSLLTY PVLMAADILA YGTDEVPVGE 150
DQTQHVELAR DLAVRFNQRY GHTFVVPRAT SPAVAARVMN LQEPASKMGK 200
SDDTGPGIVY LLDEPDVVRK KVMRAVTDSG RDVVYDPEER AGLANLLEIL 250
AACTDGEPAE LAGGYDSYGA LKKDTAEAVV EMLRPVRERH MELSADPGYV 300
DGVLREGAEK ARAMARPTVD DAYRAIGLLP PVNAAR 336
Length:336
Mass (Da):36,804
Last modified:March 1, 2003 - v1
Checksum:iF109480ADFA00373
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAD55313.1.
PIRiT36282.
RefSeqiNP_733600.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAD55313; CAD55313; CAD55313.
GeneIDi1098771.
KEGGisco:SCO3334.
PATRICi23736418. VBIStrCoe124346_3394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAD55313.1 .
PIRi T36282.
RefSeqi NP_733600.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q8CJX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3334.

Proteomic databases

PRIDEi Q8CJX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD55313 ; CAD55313 ; CAD55313 .
GeneIDi 1098771.
KEGGi sco:SCO3334.
PATRICi 23736418. VBIStrCoe124346_3394.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
KOi K01867.
OMAi PELCTVF.
OrthoDBi EOG686NJQ.
PhylomeDBi Q8CJX0.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiSYW1_STRCO
AccessioniPrimary (citable) accession number: Q8CJX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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