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Q8CJR5

- PTA_STRCO

UniProt

Q8CJR5 - PTA_STRCO

Protein

Phosphate acetyltransferase

Gene

pta

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in acetate metabolism.By similarity

    Catalytic activityi

    Acetyl-CoA + phosphate = CoA + acetyl phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphate acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00340; UER00459.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphate acetyltransferase (EC:2.3.1.8)
    Alternative name(s):
    Phosphotransacetylase
    Gene namesi
    Name:pta
    Ordered Locus Names:SCO5425
    ORF Names:SC6A11.01c, SC8F4.29c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Phosphate acetyltransferasePRO_0000405553Add
    BLAST

    Proteomic databases

    PRIDEiQ8CJR5.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi100226.SCO5425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CJR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni366 – 697332Phosphate acetyltransferaseAdd
    BLAST

    Domaini

    The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.By similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the CobB/CobQ family.Curated
    In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0280.
    HOGENOMiHOG000053797.
    KOiK13788.
    OMAiATIRPAF.
    OrthoDBiEOG6BKJ5W.
    PhylomeDBiQ8CJR5.

    Family and domain databases

    Gene3Di3.40.1390.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR010766. DRTGG.
    IPR016475. P-Actrans_bac.
    IPR027417. P-loop_NTPase.
    IPR004614. P_AcTrfase.
    IPR002505. PTA_PTB.
    IPR028979. Ser_kin/Pase_Hpr_N_like.
    [Graphical view]
    PfamiPF07085. DRTGG. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF75138. SSF75138. 1 hit.
    TIGRFAMsiTIGR00651. pta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CJR5-1 [UniParc]FASTAAdd to Basket

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    MTRSVYVTGI DRGDGRQVVE LGVMELLTRQ VDRVGVFRPL VHDGPDRLFE    50
    LLRARYRLSQ DPATVYGMDY QEASLLQAEQ GVDELVSALV DRFHLVARDY 100
    DVVLVLGTDY ADTQFPDELS LNARLANEFG ASVLPVVGGR KQTADSVLAE 150
    THNAFRAYDG LGCDVLAMVT NRVAREDRDE IAERLAHRLP VPCWVVPDEP 200
    ALSAPTVSQI AHALGAEIVL GDDSGLARDA LDFVFGGAML PNLLAALTPG 250
    CLVITPGDRA DLVIGTLAAH SAGTPPIAGV LLTLNEVPGE GILTLAARLA 300
    PGTPVLSVTG TSFPTAERLF SLEGKLGAAT PRKAETALGL FERYVDTAEL 350
    NKRVSAPSSD RVTPMMFEHK LLEQARSDLR RVVLPEGTEE RVLHAAEVLL 400
    RRGVCELTLL GPVEQIRKKA ADLGIDLGGA ELIDPAASEL RDSFAEKYAA 450
    LRAHKGVTVE LAYDVVSDVN YFGTLMVQEG FADGMVSGSV HSTAATIRPA 500
    FEIIKTKPDA AIVSSVFFMC LADKVLVYGD CAVNPDPDAE QLADIATQSA 550
    STAAQFGVEP RIAMLSYSTG TSGSGADVDK VREATELVRS RRPDLSVEGP 600
    IQYDAAVEPS VAATKLPGSA VAGQASVLIF PDLNTGNNTY KAVQRSAGAI 650
    AVGPVLQGLR KPVNDLSRGA LVQDIVNTVA ITAIQAQQSP TEKASAQ 697
    Length:697
    Mass (Da):74,047
    Last modified:March 1, 2003 - v1
    Checksum:iD52002198968B71E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939123 Genomic DNA. Translation: CAD55352.1.
    RefSeqiNP_733663.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAD55352; CAD55352; CAD55352.
    GeneIDi1100865.
    KEGGisco:SCO5425.
    PATRICi23740700. VBIStrCoe124346_5506.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939123 Genomic DNA. Translation: CAD55352.1 .
    RefSeqi NP_733663.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q8CJR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO5425.

    Proteomic databases

    PRIDEi Q8CJR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD55352 ; CAD55352 ; CAD55352 .
    GeneIDi 1100865.
    KEGGi sco:SCO5425.
    PATRICi 23740700. VBIStrCoe124346_5506.

    Phylogenomic databases

    eggNOGi COG0280.
    HOGENOMi HOG000053797.
    KOi K13788.
    OMAi ATIRPAF.
    OrthoDBi EOG6BKJ5W.
    PhylomeDBi Q8CJR5.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00459 .

    Family and domain databases

    Gene3Di 3.40.1390.20. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR010766. DRTGG.
    IPR016475. P-Actrans_bac.
    IPR027417. P-loop_NTPase.
    IPR004614. P_AcTrfase.
    IPR002505. PTA_PTB.
    IPR028979. Ser_kin/Pase_Hpr_N_like.
    [Graphical view ]
    Pfami PF07085. DRTGG. 1 hit.
    PF01515. PTA_PTB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006107. PhpActrans_proteobac. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF75138. SSF75138. 1 hit.
    TIGRFAMsi TIGR00651. pta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiPTA_STRCO
    AccessioniPrimary (citable) accession number: Q8CJR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3