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Q8CJR5 (PTA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphate acetyltransferase

EC=2.3.1.8
Alternative name(s):
Phosphotransacetylase
Gene names
Name:pta
Ordered Locus Names:SCO5425
ORF Names:SC6A11.01c, SC8F4.29c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length697 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in acetate metabolism By similarity.

Catalytic activity

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm Potential.

Domain

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.

Sequence similarities

In the N-terminal section; belongs to the CobB/CobQ family.

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacetyl-CoA biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphate acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 697697Phosphate acetyltransferase
PRO_0000405553

Regions

Region366 – 697332Phosphate acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
Q8CJR5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D52002198968B71E

FASTA69774,047
        10         20         30         40         50         60 
MTRSVYVTGI DRGDGRQVVE LGVMELLTRQ VDRVGVFRPL VHDGPDRLFE LLRARYRLSQ 

        70         80         90        100        110        120 
DPATVYGMDY QEASLLQAEQ GVDELVSALV DRFHLVARDY DVVLVLGTDY ADTQFPDELS 

       130        140        150        160        170        180 
LNARLANEFG ASVLPVVGGR KQTADSVLAE THNAFRAYDG LGCDVLAMVT NRVAREDRDE 

       190        200        210        220        230        240 
IAERLAHRLP VPCWVVPDEP ALSAPTVSQI AHALGAEIVL GDDSGLARDA LDFVFGGAML 

       250        260        270        280        290        300 
PNLLAALTPG CLVITPGDRA DLVIGTLAAH SAGTPPIAGV LLTLNEVPGE GILTLAARLA 

       310        320        330        340        350        360 
PGTPVLSVTG TSFPTAERLF SLEGKLGAAT PRKAETALGL FERYVDTAEL NKRVSAPSSD 

       370        380        390        400        410        420 
RVTPMMFEHK LLEQARSDLR RVVLPEGTEE RVLHAAEVLL RRGVCELTLL GPVEQIRKKA 

       430        440        450        460        470        480 
ADLGIDLGGA ELIDPAASEL RDSFAEKYAA LRAHKGVTVE LAYDVVSDVN YFGTLMVQEG 

       490        500        510        520        530        540 
FADGMVSGSV HSTAATIRPA FEIIKTKPDA AIVSSVFFMC LADKVLVYGD CAVNPDPDAE 

       550        560        570        580        590        600 
QLADIATQSA STAAQFGVEP RIAMLSYSTG TSGSGADVDK VREATELVRS RRPDLSVEGP 

       610        620        630        640        650        660 
IQYDAAVEPS VAATKLPGSA VAGQASVLIF PDLNTGNNTY KAVQRSAGAI AVGPVLQGLR 

       670        680        690 
KPVNDLSRGA LVQDIVNTVA ITAIQAQQSP TEKASAQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939123 Genomic DNA. Translation: CAD55352.1.
RefSeqNP_733663.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ8CJR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO5425.

Proteomic databases

PRIDEQ8CJR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD55352; CAD55352; CAD55352.
GeneID1100865.
KEGGsco:SCO5425.
PATRIC23740700. VBIStrCoe124346_5506.

Phylogenomic databases

eggNOGCOG0280.
HOGENOMHOG000053797.
KOK13788.
OMAATIRPAF.
OrthoDBEOG6BKJ5W.
PhylomeDBQ8CJR5.

Enzyme and pathway databases

UniPathwayUPA00340; UER00459.

Family and domain databases

Gene3D3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsTIGR00651. pta. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTA_STRCO
AccessionPrimary (citable) accession number: Q8CJR5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways