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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:SCO5425
ORF Names:SC6A11.01c, SC8F4.29c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055531 – 697Phosphate acetyltransferaseAdd BLAST697

Proteomic databases

PRIDEiQ8CJR5

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi100226.SCO5425

Structurei

3D structure databases

ProteinModelPortaliQ8CJR5
SMRiQ8CJR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni366 – 697Phosphate acetyltransferaseAdd BLAST332

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4105C6K Bacteria
COG0280 LUCA
COG0857 LUCA
HOGENOMiHOG000053797
InParanoidiQ8CJR5
KOiK13788
OMAiTPLMFEY
OrthoDBiPOG091H01MW
PhylomeDBiQ8CJR5

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CJR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSVYVTGI DRGDGRQVVE LGVMELLTRQ VDRVGVFRPL VHDGPDRLFE
60 70 80 90 100
LLRARYRLSQ DPATVYGMDY QEASLLQAEQ GVDELVSALV DRFHLVARDY
110 120 130 140 150
DVVLVLGTDY ADTQFPDELS LNARLANEFG ASVLPVVGGR KQTADSVLAE
160 170 180 190 200
THNAFRAYDG LGCDVLAMVT NRVAREDRDE IAERLAHRLP VPCWVVPDEP
210 220 230 240 250
ALSAPTVSQI AHALGAEIVL GDDSGLARDA LDFVFGGAML PNLLAALTPG
260 270 280 290 300
CLVITPGDRA DLVIGTLAAH SAGTPPIAGV LLTLNEVPGE GILTLAARLA
310 320 330 340 350
PGTPVLSVTG TSFPTAERLF SLEGKLGAAT PRKAETALGL FERYVDTAEL
360 370 380 390 400
NKRVSAPSSD RVTPMMFEHK LLEQARSDLR RVVLPEGTEE RVLHAAEVLL
410 420 430 440 450
RRGVCELTLL GPVEQIRKKA ADLGIDLGGA ELIDPAASEL RDSFAEKYAA
460 470 480 490 500
LRAHKGVTVE LAYDVVSDVN YFGTLMVQEG FADGMVSGSV HSTAATIRPA
510 520 530 540 550
FEIIKTKPDA AIVSSVFFMC LADKVLVYGD CAVNPDPDAE QLADIATQSA
560 570 580 590 600
STAAQFGVEP RIAMLSYSTG TSGSGADVDK VREATELVRS RRPDLSVEGP
610 620 630 640 650
IQYDAAVEPS VAATKLPGSA VAGQASVLIF PDLNTGNNTY KAVQRSAGAI
660 670 680 690
AVGPVLQGLR KPVNDLSRGA LVQDIVNTVA ITAIQAQQSP TEKASAQ
Length:697
Mass (Da):74,047
Last modified:March 1, 2003 - v1
Checksum:iD52002198968B71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939123 Genomic DNA Translation: CAD55352.1
RefSeqiNP_733663.1, NC_003888.3
WP_011030239.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAD55352; CAD55352; CAD55352
GeneIDi1100865
KEGGisco:SCO5425
PATRICifig|100226.15.peg.5506

Similar proteinsi

Entry informationi

Entry nameiPTA_STRCO
AccessioniPrimary (citable) accession number: Q8CJR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health