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Q8CJI3

- S12A8_RAT

UniProt

Q8CJI3 - S12A8_RAT

Protein

Solute carrier family 12 member 8

Gene

Slc12a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. potassium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Potassium transport, Symport, Transport

    Keywords - Ligandi

    Chloride, Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 12 member 8
    Alternative name(s):
    Cation-chloride cotransporter 9
    Gene namesi
    Name:Slc12a8
    Synonyms:Ccc9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628730. Slc12a8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707Solute carrier family 12 member 8PRO_0000305289Add
    BLAST

    Proteomic databases

    PaxDbiQ8CJI3.
    PRIDEiQ8CJI3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8CJI3.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5924HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29524HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei361 – 38020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei579 – 60022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei606 – 62318HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC12A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000045198.
    HOVERGENiHBG108430.
    InParanoidiQ8CJI3.
    KOiK14428.
    PhylomeDBiQ8CJI3.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    [Graphical view]
    PfamiPF00324. AA_permease. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CJI3-1) [UniParc]FASTAAdd to Basket

    Also known as: ccc9a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQRSPQELF HEAAQQGVLA RSQPWWKIQL FMWEPVLFGT WDGVFTSCMI    50
    NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV ILVALITVLS GIGVAEHGWM 100
    GSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYLTGF AESISDLLGL 150
    GNIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLSLLA VSTLDFVVGS 200
    FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF 250
    NMGGDLREPA DQHTPRLPSS CWVSRGFSNI IFAFLLGAVC TREALRSDFL 300
    IAEKVSLVGF LFLLGLYISS LASCMGGLYG APRILQCIAQ DKVIPALAFL 350
    GNGKGPNKTP VAAICLTSLV TMAFVLVGQV NVLAPVVTIN FMLTYIAVDY 400
    SYFALSMAHC GLAQSPEPMP RQGPDALHCS EHLLQDKAPS YGSDTPAGSL 450
    SEGTLLEFTK DMDQLLQPIG GLESQPRSRE VNQVLKSQKH KCKKDAKQTL 500
    QDSFLLDAES PLSFSMGASE RLSVASCGEQ ESYQNQQTSR SESHDHLVPD 550
    LCTQPRANGE DFFLKCRLQE QQVQRRPSAF YVCMCNPWVS LLGALASLLI 600
    MFVIQWLYTL ASMGVAALVY LYIGQASPGL YLGSASNFSF FQWMKSFLVP 650
    SCRSLRSTRE QIILAPSPAK VDMAMTQAYP GQWQTSATRE RYHRSSFLSR 700
    EQLMPPY 707
    Length:707
    Mass (Da):77,073
    Last modified:March 1, 2003 - v1
    Checksum:i96A01BA7A04EDC57
    GO
    Isoform 2 (identifier: Q8CJI3-2) [UniParc]FASTAAdd to Basket

    Also known as: ccc9b

    The sequence of this isoform differs from the canonical sequence as follows:
         354-379: Missing.
         594-611: ALASLLIMFVIQWLYTLA → EPEIHPGANHLGTVPSQG
         612-707: Missing.

    Show »
    Length:585
    Mass (Da):63,375
    Checksum:i6073486F2785D71D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti431 – 4311E → L in BAC20265. 1 PublicationCurated
    Sequence conflicti433 – 4331L → R in BAC20265. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei354 – 37926Missing in isoform 2. 1 PublicationVSP_028337Add
    BLAST
    Alternative sequencei594 – 61118ALASL…LYTLA → EPEIHPGANHLGTVPSQG in isoform 2. 1 PublicationVSP_028338Add
    BLAST
    Alternative sequencei612 – 70796Missing in isoform 2. 1 PublicationVSP_028339Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024430 mRNA. Translation: BAC20264.1.
    AB024431 mRNA. Translation: BAC20265.1.
    RefSeqiNP_705889.1. NM_153625.1. [Q8CJI3-1]
    UniGeneiRn.15381.

    Genome annotation databases

    GeneIDi266733.
    KEGGirno:266733.
    UCSCiRGD:628730. rat. [Q8CJI3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024430 mRNA. Translation: BAC20264.1 .
    AB024431 mRNA. Translation: BAC20265.1 .
    RefSeqi NP_705889.1. NM_153625.1. [Q8CJI3-1 ]
    UniGenei Rn.15381.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8CJI3.
    PRIDEi Q8CJI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 266733.
    KEGGi rno:266733.
    UCSCi RGD:628730. rat. [Q8CJI3-1 ]

    Organism-specific databases

    CTDi 84561.
    RGDi 628730. Slc12a8.

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000045198.
    HOVERGENi HBG108430.
    InParanoidi Q8CJI3.
    KOi K14428.
    PhylomeDBi Q8CJI3.

    Miscellaneous databases

    NextBioi 624577.

    Gene expression databases

    Genevestigatori Q8CJI3.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    [Graphical view ]
    Pfami PF00324. AA_permease. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a new member of cation chloride cotransporters."
      Ishibashi K., Imai M.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiS12A8_RAT
    AccessioniPrimary (citable) accession number: Q8CJI3
    Secondary accession number(s): Q8CJI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3