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Q8CJI3

- S12A8_RAT

UniProt

Q8CJI3 - S12A8_RAT

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Protein
Solute carrier family 12 member 8
Gene
Slc12a8, Ccc9
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation By similarity.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. potassium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Symport, Transport

Keywords - Ligandi

Chloride, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 8
Alternative name(s):
Cation-chloride cotransporter 9
Gene namesi
Name:Slc12a8
Synonyms:Ccc9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628730. Slc12a8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5924Helical; Reviewed prediction
Add
BLAST
Transmembranei71 – 9222Helical; Reviewed prediction
Add
BLAST
Transmembranei98 – 11518Helical; Reviewed prediction
Add
BLAST
Transmembranei122 – 14120Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17220Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25120Helical; Reviewed prediction
Add
BLAST
Transmembranei272 – 29524Helical; Reviewed prediction
Add
BLAST
Transmembranei307 – 32923Helical; Reviewed prediction
Add
BLAST
Transmembranei361 – 38020Helical; Reviewed prediction
Add
BLAST
Transmembranei392 – 41221Helical; Reviewed prediction
Add
BLAST
Transmembranei579 – 60022Helical; Reviewed prediction
Add
BLAST
Transmembranei606 – 62318Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Solute carrier family 12 member 8
PRO_0000305289Add
BLAST

Proteomic databases

PaxDbiQ8CJI3.
PRIDEiQ8CJI3.

Expressioni

Gene expression databases

GenevestigatoriQ8CJI3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000045198.
HOVERGENiHBG108430.
InParanoidiQ8CJI3.
KOiK14428.
PhylomeDBiQ8CJI3.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CJI3-1) [UniParc]FASTAAdd to Basket

Also known as: ccc9a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQRSPQELF HEAAQQGVLA RSQPWWKIQL FMWEPVLFGT WDGVFTSCMI    50
NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV ILVALITVLS GIGVAEHGWM 100
GSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYLTGF AESISDLLGL 150
GNIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLSLLA VSTLDFVVGS 200
FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF 250
NMGGDLREPA DQHTPRLPSS CWVSRGFSNI IFAFLLGAVC TREALRSDFL 300
IAEKVSLVGF LFLLGLYISS LASCMGGLYG APRILQCIAQ DKVIPALAFL 350
GNGKGPNKTP VAAICLTSLV TMAFVLVGQV NVLAPVVTIN FMLTYIAVDY 400
SYFALSMAHC GLAQSPEPMP RQGPDALHCS EHLLQDKAPS YGSDTPAGSL 450
SEGTLLEFTK DMDQLLQPIG GLESQPRSRE VNQVLKSQKH KCKKDAKQTL 500
QDSFLLDAES PLSFSMGASE RLSVASCGEQ ESYQNQQTSR SESHDHLVPD 550
LCTQPRANGE DFFLKCRLQE QQVQRRPSAF YVCMCNPWVS LLGALASLLI 600
MFVIQWLYTL ASMGVAALVY LYIGQASPGL YLGSASNFSF FQWMKSFLVP 650
SCRSLRSTRE QIILAPSPAK VDMAMTQAYP GQWQTSATRE RYHRSSFLSR 700
EQLMPPY 707
Length:707
Mass (Da):77,073
Last modified:March 1, 2003 - v1
Checksum:i96A01BA7A04EDC57
GO
Isoform 2 (identifier: Q8CJI3-2) [UniParc]FASTAAdd to Basket

Also known as: ccc9b

The sequence of this isoform differs from the canonical sequence as follows:
     354-379: Missing.
     594-611: ALASLLIMFVIQWLYTLA → EPEIHPGANHLGTVPSQG
     612-707: Missing.

Show »
Length:585
Mass (Da):63,375
Checksum:i6073486F2785D71D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei354 – 37926Missing in isoform 2.
VSP_028337Add
BLAST
Alternative sequencei594 – 61118ALASL…LYTLA → EPEIHPGANHLGTVPSQG in isoform 2.
VSP_028338Add
BLAST
Alternative sequencei612 – 70796Missing in isoform 2.
VSP_028339Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti431 – 4311E → L in BAC20265. 1 Publication
Sequence conflicti433 – 4331L → R in BAC20265. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024430 mRNA. Translation: BAC20264.1.
AB024431 mRNA. Translation: BAC20265.1.
RefSeqiNP_705889.1. NM_153625.1. [Q8CJI3-1]
UniGeneiRn.15381.

Genome annotation databases

GeneIDi266733.
KEGGirno:266733.
UCSCiRGD:628730. rat. [Q8CJI3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024430 mRNA. Translation: BAC20264.1 .
AB024431 mRNA. Translation: BAC20265.1 .
RefSeqi NP_705889.1. NM_153625.1. [Q8CJI3-1 ]
UniGenei Rn.15381.

3D structure databases

ModBasei Search...

Proteomic databases

PaxDbi Q8CJI3.
PRIDEi Q8CJI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 266733.
KEGGi rno:266733.
UCSCi RGD:628730. rat. [Q8CJI3-1 ]

Organism-specific databases

CTDi 84561.
RGDi 628730. Slc12a8.

Phylogenomic databases

eggNOGi COG0531.
HOGENOMi HOG000045198.
HOVERGENi HBG108430.
InParanoidi Q8CJI3.
KOi K14428.
PhylomeDBi Q8CJI3.

Miscellaneous databases

NextBioi 624577.

Gene expression databases

Genevestigatori Q8CJI3.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a new member of cation chloride cotransporters."
    Ishibashi K., Imai M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiS12A8_RAT
AccessioniPrimary (citable) accession number: Q8CJI3
Secondary accession number(s): Q8CJI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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