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Q8CJI3

- S12A8_RAT

UniProt

Q8CJI3 - S12A8_RAT

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Protein

Solute carrier family 12 member 8

Gene

Slc12a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.By similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. potassium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Symport, Transport

Keywords - Ligandi

Chloride, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 12 member 8
Alternative name(s):
Cation-chloride cotransporter 9
Gene namesi
Name:Slc12a8
Synonyms:Ccc9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628730. Slc12a8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Solute carrier family 12 member 8PRO_0000305289Add
BLAST

Proteomic databases

PaxDbiQ8CJI3.
PRIDEiQ8CJI3.

Expressioni

Gene expression databases

GenevestigatoriQ8CJI3.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5924HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9222HelicalSequence AnalysisAdd
BLAST
Transmembranei98 – 11518HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14120HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17220HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25120HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29524HelicalSequence AnalysisAdd
BLAST
Transmembranei307 – 32923HelicalSequence AnalysisAdd
BLAST
Transmembranei361 – 38020HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Transmembranei579 – 60022HelicalSequence AnalysisAdd
BLAST
Transmembranei606 – 62318HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000045198.
HOVERGENiHBG108430.
InParanoidiQ8CJI3.
KOiK14428.
PhylomeDBiQ8CJI3.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CJI3) [UniParc]FASTAAdd to Basket

Also known as: ccc9a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRSPQELF HEAAQQGVLA RSQPWWKIQL FMWEPVLFGT WDGVFTSCMI
60 70 80 90 100
NIFGVVLFLR TGWLVGNTGV LLGLLLVSFV ILVALITVLS GIGVAEHGWM
110 120 130 140 150
GSGGVYSMIS SVLGGQMGGT VGLLYVFGQC VAGAMYLTGF AESISDLLGL
160 170 180 190 200
GNIWAVRGIS VAVLLALLGI NLAGVKWIIR LQLLLLSLLA VSTLDFVVGS
210 220 230 240 250
FTHLDPEHGF IGYSPELLQS NILPEYSPGE SFFTVFGVFF PAATGVMAGF
260 270 280 290 300
NMGGDLREPA DQHTPRLPSS CWVSRGFSNI IFAFLLGAVC TREALRSDFL
310 320 330 340 350
IAEKVSLVGF LFLLGLYISS LASCMGGLYG APRILQCIAQ DKVIPALAFL
360 370 380 390 400
GNGKGPNKTP VAAICLTSLV TMAFVLVGQV NVLAPVVTIN FMLTYIAVDY
410 420 430 440 450
SYFALSMAHC GLAQSPEPMP RQGPDALHCS EHLLQDKAPS YGSDTPAGSL
460 470 480 490 500
SEGTLLEFTK DMDQLLQPIG GLESQPRSRE VNQVLKSQKH KCKKDAKQTL
510 520 530 540 550
QDSFLLDAES PLSFSMGASE RLSVASCGEQ ESYQNQQTSR SESHDHLVPD
560 570 580 590 600
LCTQPRANGE DFFLKCRLQE QQVQRRPSAF YVCMCNPWVS LLGALASLLI
610 620 630 640 650
MFVIQWLYTL ASMGVAALVY LYIGQASPGL YLGSASNFSF FQWMKSFLVP
660 670 680 690 700
SCRSLRSTRE QIILAPSPAK VDMAMTQAYP GQWQTSATRE RYHRSSFLSR

EQLMPPY
Length:707
Mass (Da):77,073
Last modified:March 1, 2003 - v1
Checksum:i96A01BA7A04EDC57
GO
Isoform 2 (identifier: Q8CJI3-2) [UniParc]FASTAAdd to Basket

Also known as: ccc9b

The sequence of this isoform differs from the canonical sequence as follows:
     354-379: Missing.
     594-611: ALASLLIMFVIQWLYTLA → EPEIHPGANHLGTVPSQG
     612-707: Missing.

Show »
Length:585
Mass (Da):63,375
Checksum:i6073486F2785D71D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti431 – 4311E → L in BAC20265. 1 PublicationCurated
Sequence conflicti433 – 4331L → R in BAC20265. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei354 – 37926Missing in isoform 2. 1 PublicationVSP_028337Add
BLAST
Alternative sequencei594 – 61118ALASL…LYTLA → EPEIHPGANHLGTVPSQG in isoform 2. 1 PublicationVSP_028338Add
BLAST
Alternative sequencei612 – 70796Missing in isoform 2. 1 PublicationVSP_028339Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024430 mRNA. Translation: BAC20264.1.
AB024431 mRNA. Translation: BAC20265.1.
RefSeqiNP_705889.1. NM_153625.1. [Q8CJI3-1]
UniGeneiRn.15381.

Genome annotation databases

GeneIDi266733.
KEGGirno:266733.
UCSCiRGD:628730. rat. [Q8CJI3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024430 mRNA. Translation: BAC20264.1 .
AB024431 mRNA. Translation: BAC20265.1 .
RefSeqi NP_705889.1. NM_153625.1. [Q8CJI3-1 ]
UniGenei Rn.15381.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8CJI3.
PRIDEi Q8CJI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 266733.
KEGGi rno:266733.
UCSCi RGD:628730. rat. [Q8CJI3-1 ]

Organism-specific databases

CTDi 84561.
RGDi 628730. Slc12a8.

Phylogenomic databases

eggNOGi COG0531.
HOGENOMi HOG000045198.
HOVERGENi HBG108430.
InParanoidi Q8CJI3.
KOi K14428.
PhylomeDBi Q8CJI3.

Miscellaneous databases

NextBioi 624577.

Gene expression databases

Genevestigatori Q8CJI3.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a new member of cation chloride cotransporters."
    Ishibashi K., Imai M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiS12A8_RAT
AccessioniPrimary (citable) accession number: Q8CJI3
Secondary accession number(s): Q8CJI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3