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Q8CJH7

- Q8CJH7_RAT

UniProt

Q8CJH7 - Q8CJH7_RAT

Protein
Submitted name:

Pit-1

Gene

Prop1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. blood vessel development Source: Ensembl
    2. canonical Wnt signaling pathway Source: Ensembl
    3. cell migration Source: Ensembl
    4. dorsal/ventral pattern formation Source: Ensembl
    5. hypophysis morphogenesis Source: Ensembl
    6. hypothalamus cell differentiation Source: Ensembl
    7. negative regulation of apoptotic process Source: Ensembl
    8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. somatotropin secreting cell differentiation Source: Ensembl

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pit-1Imported
    Submitted name:
    Protein Prop1Imported
    Gene namesi
    Name:Prop1Imported
    Synonyms:Prop-1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi628759. Prop1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    PTM / Processingi

    PTM databases

    PhosphoSiteiQ8CJH7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8CJH7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004872.

    Family & Domainsi

    Keywords - Domaini

    HomeoboxUniRule annotation

    Phylogenomic databases

    eggNOGiNOG293463.
    GeneTreeiENSGT00750000117223.
    HOGENOMiHOG000115706.
    HOVERGENiHBG053691.
    InParanoidiQ8CJH7.
    KOiK09327.
    OMAiHQSEDWY.
    OrthoDBiEOG7P8P9G.
    TreeFamiTF315976.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CJH7-1 [UniParc]FASTAAdd to Basket

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    MEAQRRSQQE KQTKGPVCGR SLPESQAASG TLISTVDRSP ETSKRLSGTG    50
    LGRPKLCPQR GRPHSRRRHR TTFNPAQLGQ LESAFGRNQY PDIWVREGLA 100
    QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PTAHLSPATF SGFLSESSPY 150
    PYTYTTPPPP VPCFPHPYNH ALPSQPCTGA SLTLPAQPED WYPTLHPTHT 200
    GHLACPPPPP MFSLSLETPK SWN 223
    Length:223
    Mass (Da):24,881
    Last modified:March 1, 2003 - v1
    Checksum:iAABC2CCE2F129EA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06063791 Genomic DNA. No translation available.
    AB037922 mRNA. Translation: BAC20638.1.
    RefSeqiNP_705891.1. NM_153627.1.
    UniGeneiRn.86655.

    Genome annotation databases

    EnsembliENSRNOT00000004872; ENSRNOP00000004872; ENSRNOG00000003671.
    GeneIDi266738.
    KEGGirno:266738.
    UCSCiRGD:628759. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06063791 Genomic DNA. No translation available.
    AB037922 mRNA. Translation: BAC20638.1 .
    RefSeqi NP_705891.1. NM_153627.1.
    UniGenei Rn.86655.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004872.

    PTM databases

    PhosphoSitei Q8CJH7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004872 ; ENSRNOP00000004872 ; ENSRNOG00000003671 .
    GeneIDi 266738.
    KEGGi rno:266738.
    UCSCi RGD:628759. rat.

    Organism-specific databases

    CTDi 5626.
    RGDi 628759. Prop1.

    Phylogenomic databases

    eggNOGi NOG293463.
    GeneTreei ENSGT00750000117223.
    HOGENOMi HOG000115706.
    HOVERGENi HBG053691.
    InParanoidi Q8CJH7.
    KOi K09327.
    OMAi HQSEDWY.
    OrthoDBi EOG7P8P9G.
    TreeFami TF315976.

    Miscellaneous databases

    NextBioi 624589.
    PROi Q8CJH7.

    Gene expression databases

    Genevestigatori Q8CJH7.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "rat prophet of pit-1 (Prop-1). completel code."
      Kitagawa Y., Nakamura K., Inoue K., Sakai T.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HeadImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ8CJH7_RAT
    AccessioniPrimary (citable) accession number: Q8CJH7
    Secondary accession number(s): E9PTF1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3