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Q8CJH7

- Q8CJH7_RAT

UniProt

Q8CJH7 - Q8CJH7_RAT

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Protein
Submitted name:

Pit-1

Gene

Prop1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. blood vessel development Source: Ensembl
  2. canonical Wnt signaling pathway Source: Ensembl
  3. cell migration Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. hypophysis morphogenesis Source: Ensembl
  6. hypothalamus cell differentiation Source: Ensembl
  7. negative regulation of apoptotic process Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. somatotropin secreting cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Pit-1Imported
Submitted name:
Protein Prop1Imported
Gene namesi
Name:Prop1Imported
Synonyms:Prop-1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi628759. Prop1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

PTM databases

PhosphoSiteiQ8CJH7.

Expressioni

Gene expression databases

GenevestigatoriQ8CJH7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004872.

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotation

Phylogenomic databases

eggNOGiNOG293463.
GeneTreeiENSGT00760000118908.
HOGENOMiHOG000115706.
HOVERGENiHBG053691.
KOiK09327.
OMAiHQSEDWY.
OrthoDBiEOG7P8P9G.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CJH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAQRRSQQE KQTKGPVCGR SLPESQAASG TLISTVDRSP ETSKRLSGTG
60 70 80 90 100
LGRPKLCPQR GRPHSRRRHR TTFNPAQLGQ LESAFGRNQY PDIWVREGLA
110 120 130 140 150
QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PTAHLSPATF SGFLSESSPY
160 170 180 190 200
PYTYTTPPPP VPCFPHPYNH ALPSQPCTGA SLTLPAQPED WYPTLHPTHT
210 220
GHLACPPPPP MFSLSLETPK SWN
Length:223
Mass (Da):24,881
Last modified:March 1, 2003 - v1
Checksum:iAABC2CCE2F129EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06063791 Genomic DNA. No translation available.
AB037922 mRNA. Translation: BAC20638.1.
RefSeqiNP_705891.1. NM_153627.1.
UniGeneiRn.86655.

Genome annotation databases

EnsembliENSRNOT00000004872; ENSRNOP00000004872; ENSRNOG00000003671.
GeneIDi266738.
KEGGirno:266738.
UCSCiRGD:628759. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06063791 Genomic DNA. No translation available.
AB037922 mRNA. Translation: BAC20638.1 .
RefSeqi NP_705891.1. NM_153627.1.
UniGenei Rn.86655.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004872.

PTM databases

PhosphoSitei Q8CJH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004872 ; ENSRNOP00000004872 ; ENSRNOG00000003671 .
GeneIDi 266738.
KEGGi rno:266738.
UCSCi RGD:628759. rat.

Organism-specific databases

CTDi 5626.
RGDi 628759. Prop1.

Phylogenomic databases

eggNOGi NOG293463.
GeneTreei ENSGT00760000118908.
HOGENOMi HOG000115706.
HOVERGENi HBG053691.
KOi K09327.
OMAi HQSEDWY.
OrthoDBi EOG7P8P9G.
TreeFami TF315976.

Miscellaneous databases

NextBioi 624589.
PROi Q8CJH7.

Gene expression databases

Genevestigatori Q8CJH7.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "rat prophet of pit-1 (Prop-1). completel code."
    Kitagawa Y., Nakamura K., Inoue K., Sakai T.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeadImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ8CJH7_RAT
AccessioniPrimary (citable) accession number: Q8CJH7
Secondary accession number(s): E9PTF1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3