Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal PAS domain-containing protein 4

Gene

Npas4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal PAS domain-containing protein 4
Short name:
Neuronal PAS4
Alternative name(s):
HLH-PAS transcription factor NXF
Gene namesi
Name:Npas4
Synonyms:Nxf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628866. Npas4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Neuronal PAS domain-containing protein 4PRO_0000248224Add
BLAST

Proteomic databases

PaxDbiQ8CJH6.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNT (By similarity).By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027119.

Structurei

3D structure databases

ProteinModelPortaliQ8CJH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5353bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini70 – 14475PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini203 – 27573PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini280 – 31940PACAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 3834Sequence analysisAdd
BLAST
Coiled coili624 – 64825Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IISB. Eukaryota.
ENOG4110GBU. LUCA.
GeneTreeiENSGT00530000064165.
HOGENOMiHOG000113839.
HOVERGENiHBG082054.
InParanoidiQ8CJH6.
OMAiQAKPGGW.
OrthoDBiEOG7DNNTP.
PhylomeDBiQ8CJH6.
TreeFamiTF319684.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CJH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRSTKGASK ARRDQINAEI RNLKELLPLA EADKVRLSYL HIMSLACIYT
60 70 80 90 100
RKGVFFAGGT PLAGPTGLLS AQELEDIVAA LPGFLLVFTA EGKLLYLSES
110 120 130 140 150
VSEHLGHSMV DLVAQGDSIY DIIDPADHLT VRQQLTMPSA LDADRLFRCR
160 170 180 190 200
FNTSKSLRRQ SAGNKLVLIR GRFHAHPPGA YWAGNPVFTA FCAPLEPRPR
210 220 230 240 250
PGPGPGPGPG PASLFLAMFQ SRHAKDLALL DISESVLIYL GFERSELLCK
260 270 280 290 300
SWYGLLHPED LAHASSQHYR LLAENGDIQA EMVVRLQAKH GGWTWIYCML
310 320 330 340 350
YSDGPEGPIT ANNYPISDTE AWSLRQQLNS ENTQAAYVLG TPAVLPSFSE
360 370 380 390 400
NVFSQEHCSN PLFTPALGTP RSASFPRAPE LGVISTSEEL AQPSKELDFS
410 420 430 440 450
YLPFPARPEP SLQADLSKDL VCTPPYTPHQ PGGCAFLFSL HEPFQTHLPP
460 470 480 490 500
PSSSLQEQLT PSTVTFSEQL TPSSATFPDP LTSSLQGQLT ESSARSFEEQ
510 520 530 540 550
LTPCTSTFPD QLLPSTATFP EPLGSPTHEQ LTPPSTAFQA HLNSPSQTFP
560 570 580 590 600
EQLSPNPTKT YFAQEGCSFL YEKLPPSPSS PGNGDCTLLA LAQLRGPLSV
610 620 630 640 650
DVPLVPEGLL TPEASPVKQS FFHYTEKEQN EIDRLIQQIS QLAQGMDRPF
660 670 680 690 700
SAEAGTGGLE PLGGLEPLNP NLSLSGAGPP VLSLDLKPWK CQELDFLVDP
710 720 730 740 750
DNLFLEETPV EDIFMDLSTP DPNGEWGSGD PEAEVPGGTL SPCNNLSPED
760 770 780 790 800
HSFLEDLATY ETAFETGVST FPYEGFADEL HQLQSQVQDS FHEDGSGGEP

TF
Length:802
Mass (Da):87,318
Last modified:March 1, 2003 - v1
Checksum:i600AA9FBB6D11E25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050103 mRNA. Translation: BAC19832.1.
RefSeqiNP_705890.1. NM_153626.1.
XP_006230759.1. XM_006230697.2.
UniGeneiRn.86654.

Genome annotation databases

EnsembliENSRNOT00000027119; ENSRNOP00000027119; ENSRNOG00000020009.
GeneIDi266734.
KEGGirno:266734.
UCSCiRGD:628866. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050103 mRNA. Translation: BAC19832.1.
RefSeqiNP_705890.1. NM_153626.1.
XP_006230759.1. XM_006230697.2.
UniGeneiRn.86654.

3D structure databases

ProteinModelPortaliQ8CJH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027119.

Proteomic databases

PaxDbiQ8CJH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027119; ENSRNOP00000027119; ENSRNOG00000020009.
GeneIDi266734.
KEGGirno:266734.
UCSCiRGD:628866. rat.

Organism-specific databases

CTDi266743.
RGDi628866. Npas4.

Phylogenomic databases

eggNOGiENOG410IISB. Eukaryota.
ENOG4110GBU. LUCA.
GeneTreeiENSGT00530000064165.
HOGENOMiHOG000113839.
HOVERGENiHBG082054.
InParanoidiQ8CJH6.
OMAiQAKPGGW.
OrthoDBiEOG7DNNTP.
PhylomeDBiQ8CJH6.
TreeFamiTF319684.

Miscellaneous databases

PROiQ8CJH6.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression."
    Ooe N., Saito K., Mikami N., Nakatuka I., Kaneko H.
    Mol. Cell. Biol. 24:608-616(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiNPAS4_RAT
AccessioniPrimary (citable) accession number: Q8CJH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.