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Q8CJH3

- PLXB1_MOUSE

UniProt

Q8CJH3 - PLXB1_MOUSE

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Protein

Plexin-B1

Gene

Plxnb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1799 – 17991Important for interaction with RAC1 and RND1By similarity

GO - Molecular functioni

  1. GTPase activating protein binding Source: BHF-UCL
  2. semaphorin receptor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of cell adhesion Source: UniProtKB
  2. negative regulation of osteoblast proliferation Source: BHF-UCL
  3. neuron projection morphogenesis Source: UniProtKB
  4. ossification involved in bone maturation Source: BHF-UCL
  5. positive regulation of axonogenesis Source: MGI
  6. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  7. positive regulation of Rho GTPase activity Source: UniProtKB
  8. regulation of cell shape Source: UniProtKB
  9. regulation of cytoskeleton organization Source: UniProtKB
  10. semaphorin-plexin signaling pathway Source: UniProtKB
  11. semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-B1
Gene namesi
Name:Plxnb1
Synonyms:Kiaa0407
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2154238. Plxnb1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. intracellular Source: InterPro
  3. semaphorin receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 21192100Plexin-B1PRO_0000024672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi79 ↔ 88PROSITE-ProRule annotation
Disulfide bondi111 ↔ 119PROSITE-ProRule annotation
Disulfide bondi252 ↔ 377PROSITE-ProRule annotation
Disulfide bondi268 ↔ 322PROSITE-ProRule annotation
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi340 ↔ 364PROSITE-ProRule annotation
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi482 ↔ 499PROSITE-ProRule annotation
Disulfide bondi488 ↔ 533PROSITE-ProRule annotation
Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 514PROSITE-ProRule annotation
Glycosylationi543 – 5431N-linked (GlcNAc...)1 Publication
Disulfide bondi570 ↔ 588PROSITE-ProRule annotation
Glycosylationi1251 – 12511N-linked (GlcNAc...)1 Publication
Glycosylationi1314 – 13141N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.By similarity
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8CJH3.
PaxDbiQ8CJH3.
PRIDEiQ8CJH3.

PTM databases

PhosphoSiteiQ8CJH3.

Expressioni

Tissue specificityi

Detected in brain, heart, lung, liver, kidney, stomach, testis, uterus and placenta.1 Publication

Gene expression databases

BgeeiQ8CJH3.
CleanExiMM_PLXNB1.
ExpressionAtlasiQ8CJH3. baseline and differential.
GenevestigatoriQ8CJH3.

Interactioni

Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Interacts with RRAS, ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, RHOD, NRP1 and NRP2 (By similarity). Binds PLXNA1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef11Q68FM75EBI-2637650,EBI-2365869
Arhgef12Q8R4H22EBI-2637650,EBI-8046267

Protein-protein interaction databases

IntActiQ8CJH3. 4 interactions.
MINTiMINT-1791147.

Structurei

3D structure databases

ProteinModelPortaliQ8CJH3.
SMRiQ8CJH3. Positions 25-533, 1544-2113.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 14741455ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1496 – 2119624CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1475 – 149521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 479460SemaPROSITE-ProRule annotationAdd
BLAST
Domaini1068 – 115891IPT/TIG 1Add
BLAST
Domaini1160 – 124788IPT/TIG 2Add
BLAST
Domaini1250 – 1359110IPT/TIG 3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1492 – 152332Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi678 – 835158Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 3 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254546.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiQ8CJH3.
KOiK06821.
OMAiGVMCPSP.
OrthoDBiEOG7Q8CM9.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJH3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVLGPVLLQ VFWAGCVVTL RSPLPAAFTA NGTHLQHLAR DPTTGTLYVG
60 70 80 90 100
ATNFLFQLSP GLQLEAVVST GPVNDSRDCL PPVIPDECPQ AQPTNNPNQL
110 120 130 140 150
LLVSPEALVV CGSVHQGICE LRSLGQIRQL LLRPERPGDT QYVAANDPAV
160 170 180 190 200
STVGLVAQGL VGEPLLFVGR GYTSRGVGGG IPPITTRALR PPDPQAAFSY
210 220 230 240 250
EETAKLAVGR LSEYSHHFVS AFVRGASAYF LFLRRDLKAP SRAFRAYVSR
260 270 280 290 300
VCLQDQHYYS YVELPLACQG GRYGLIQAAA VATSKEVARG DVLFAAFSSV
310 320 330 340 350
APPTVDWPLS ASTGASGTSV LCAFPLDEVD QLANYTRDAC YTREGRAENG
360 370 380 390 400
TKVADIAYDV LSDCAQLPVD TPDAFPCGSD HTPSPMVSCV PLEATPILEL
410 420 430 440 450
PGVQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGRSAA PYSKQSIQPG
460 470 480 490 500
SPVNRDLTFD GTFEHLYVAT QTTLVKVPVA PCAQHLDCDS CLAHRDPYCG
510 520 530 540 550
WCVLLGRCSR RSECSRDQGP EQWLWSFQPE LGCLRVVAVS PANISREERR
560 570 580 590 600
EVFLSVPGLP SLWPGESYFC YFGDQQSPAL LTSSGVMCPS PDPSEAPVLQ
610 620 630 640 650
RGADHISVNV ELRFGAVVIA STSLSFYDCV AVTASSPSAP CRACVSSRWG
660 670 680 690 700
CNWCVWQQLC THKASCDAGP MVASQQSPLL PLIPPARDEL TPFPPTVPQT
710 720 730 740 750
TVTPTPNSFP IEPRAPSTAS DVLPGAKPSR LSLWGPWAGP GPILSPTSTE
760 770 780 790 800
SPLHEKPLPP DPPTIPGTTV PAPTGLGPST TPEDLLASYP FPSDAAAVSP
810 820 830 840 850
AEPGPEALPS MVALDQPPGT VPDTTFPGAP GSMKPVLDWL TKGGGELPEA
860 870 880 890 900
DEWMGGDTPA FSTSTLLSGD GDSAEHEGPP APLILLSSLD YQYDTPGLWE
910 920 930 940 950
LGEVNQRVSS CPCVETVQGS LLIPVHVERE VQLRGRNLWL FQDGPRSSEC
960 970 980 990 1000
VLELGSREVA VEAQVECAPP PDVWCHIKCQ QHQFSYEALK PELQVGLFLR
1010 1020 1030 1040 1050
WAGGLRVDSA DGLHVVLYDC SVGHGDCSRC QTAMPQYDCV WCEGERPRCV
1060 1070 1080 1090 1100
AREACNEAET VATQCPAPLI HSVDPLTGPI DGGTRVTIRG SNLGQHVQDV
1110 1120 1130 1140 1150
LDMVRVAGVP CAVDAGEYDV SSSLVCITGA SGEEVTGTVA VEVPGRGHGV
1160 1170 1180 1190 1200
SEFSFAYQDP KVHSIFPARG PRAGGTRLTL HGSKLLTGRL EDIRVVVGDQ
1210 1220 1230 1240 1250
PCHLLLEQQS EQLHCETGPY PVPAELPVTV LFGATERRLQ HGQFKYTSDP
1260 1270 1280 1290 1300
NVTSVGPSKS FFSGGREIWV RGQDLDVVQR PRIRVTVVPR QHGQGLAQKQ
1310 1320 1330 1340 1350
HVVPEKFEEP CLVNSSHLLM CRTPALPGPP WDSGVQVEFI LDNMVFDFAA
1360 1370 1380 1390 1400
LSPTPFSYEA DPTLRSLNPE DPSTPFRHKP GSVFSVEGEN LDLAMSKEEV
1410 1420 1430 1440 1450
VAMIGDGPCV VKTLTRNHLY CEPPVEQPLP HPHALREAPD ALPEFTVQMG
1460 1470 1480 1490 1500
NLRFSLGHVQ YDGESPVAFP VAAQVGLGVG TSLLALGVII IVLIYRRKSK
1510 1520 1530 1540 1550
QALRDYKKVQ IQLENLESSV RDRCKKEFTD LMTEMTDLTS DLLGSGIPFL
1560 1570 1580 1590 1600
DYKVYAERVF FPGYRESPLH RDLGVPDSRR PTVEQGLGQL SNLLNSKLFL
1610 1620 1630 1640 1650
TKFIHTLESQ RTFSARDRAY VASLLTVALH GKLEYFTDIL RTLLSDLVAQ
1660 1670 1680 1690 1700
YVAKNPKLML RRTETVVEKL LTNWMSICLY TFVRDSVGEP LYMLFRGIKH
1710 1720 1730 1740 1750
QVDKGPVDSV TGKAKYTLND NRLLREDVEY RPLTLNALLA VGPGAGEAQC
1760 1770 1780 1790 1800
VPVKVLDCDT ISQAKEKMLD QLYKGVPLAQ RPDSCTLDVE WRSGVAGHLI
1810 1820 1830 1840 1850
LSDEDVTSEL QGLWRRLNTL QHYKVPDGAT VALVPCLTKH ILRENQDYVP
1860 1870 1880 1890 1900
GERTPMLEDV DEGGIRPWHL VKPSDEPEPP RPRRGSLRGG ERERAKAIPE
1910 1920 1930 1940 1950
IYLTRLLSMK GTLQKFVDDL FQVILSTSRP VPLAVKYFFD LLDEQAQQHG
1960 1970 1980 1990 2000
ISDQDTIHIW KTNSLPLRFW INIIKNPQFV FDVQTSDNMD AVLLVIAQTF
2010 2020 2030 2040 2050
MDACTLADHK LGRDSPINKL LYARDIPRYK QMVERYYADI RQTVPASDQE
2060 2070 2080 2090 2100
MNSVLAELSR NCSADLGARV ALHELYKYIN KYYDQIITAL EEDGTAQKMQ
2110
LGYRLQQIAA AVENKVTDL
Length:2,119
Mass (Da):231,376
Last modified:July 27, 2011 - v2
Checksum:i08FB5ECD2E6DE342
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361Q → L in BAC22660. (PubMed:12559962)Curated
Sequence conflicti1777 – 17771P → L in BAC97943. (PubMed:14621295)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072381 mRNA. Translation: BAC22660.1.
AC140383 Genomic DNA. No translation available.
AC174646 Genomic DNA. No translation available.
AK129133 mRNA. Translation: BAC97943.1.
BC043322 mRNA. Translation: AAH43322.1.
CCDSiCCDS23546.1.
RefSeqiNP_766363.2. NM_172775.2.
XP_006512138.1. XM_006512075.1.
XP_006512139.1. XM_006512076.1.
XP_006512140.1. XM_006512077.1.
XP_006512141.1. XM_006512078.1.
XP_006512142.1. XM_006512079.1.
XP_006512143.1. XM_006512080.1.
UniGeneiMm.53862.

Genome annotation databases

EnsembliENSMUST00000072093; ENSMUSP00000071966; ENSMUSG00000053646.
GeneIDi235611.
KEGGimmu:235611.
UCSCiuc009rrz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072381 mRNA. Translation: BAC22660.1 .
AC140383 Genomic DNA. No translation available.
AC174646 Genomic DNA. No translation available.
AK129133 mRNA. Translation: BAC97943.1 .
BC043322 mRNA. Translation: AAH43322.1 .
CCDSi CCDS23546.1.
RefSeqi NP_766363.2. NM_172775.2.
XP_006512138.1. XM_006512075.1.
XP_006512139.1. XM_006512076.1.
XP_006512140.1. XM_006512077.1.
XP_006512141.1. XM_006512078.1.
XP_006512142.1. XM_006512079.1.
XP_006512143.1. XM_006512080.1.
UniGenei Mm.53862.

3D structure databases

ProteinModelPortali Q8CJH3.
SMRi Q8CJH3. Positions 25-533, 1544-2113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CJH3. 4 interactions.
MINTi MINT-1791147.

PTM databases

PhosphoSitei Q8CJH3.

Proteomic databases

MaxQBi Q8CJH3.
PaxDbi Q8CJH3.
PRIDEi Q8CJH3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072093 ; ENSMUSP00000071966 ; ENSMUSG00000053646 .
GeneIDi 235611.
KEGGi mmu:235611.
UCSCi uc009rrz.2. mouse.

Organism-specific databases

CTDi 5364.
MGIi MGI:2154238. Plxnb1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG254546.
GeneTreei ENSGT00760000119048.
HOGENOMi HOG000231376.
HOVERGENi HBG053404.
InParanoidi Q8CJH3.
KOi K06821.
OMAi GVMCPSP.
OrthoDBi EOG7Q8CM9.
TreeFami TF312962.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.

Miscellaneous databases

NextBioi 382789.
PROi Q8CJH3.
SOURCEi Search...

Gene expression databases

Bgeei Q8CJH3.
CleanExi MM_PLXNB1.
ExpressionAtlasi Q8CJH3. baseline and differential.
Genevestigatori Q8CJH3.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view ]
SMARTi SM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains."
    Usui H., Taniguchi M., Yokomizo T., Shimizu T.
    Biochem. Biophys. Res. Commun. 300:927-931(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PLXNA1.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 913-2119.
    Tissue: Embryonic tail.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1885-2119.
    Tissue: Eye.
  5. "The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways."
    Vodrazka P., Korostylev A., Hirschberg A., Swiercz J.M., Worzfeld T., Deng S., Fazzari P., Tamagnone L., Offermanns S., Kuner R.
    Eur. J. Neurosci. 30:1193-1208(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-543 AND ASN-1251.

Entry informationi

Entry nameiPLXB1_MOUSE
AccessioniPrimary (citable) accession number: Q8CJH3
Secondary accession number(s): E9QKS4, Q6ZQC3, Q80ZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3