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Q8CJH3

- PLXB1_MOUSE

UniProt

Q8CJH3 - PLXB1_MOUSE

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Protein
Plexin-B1
Gene
Plxnb1, Kiaa0407
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1799 – 17991Important for interaction with RAC1 and RND1 By similarity

GO - Molecular functioni

  1. GTPase activating protein binding Source: BHF-UCL
  2. protein binding Source: IntAct
  3. semaphorin receptor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of cell adhesion Source: UniProtKB
  2. negative regulation of osteoblast proliferation Source: BHF-UCL
  3. neuron projection morphogenesis Source: UniProtKB
  4. ossification involved in bone maturation Source: BHF-UCL
  5. positive regulation of Rho GTPase activity Source: UniProtKB
  6. positive regulation of axonogenesis Source: MGI
  7. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  8. regulation of cell shape Source: UniProtKB
  9. regulation of cytoskeleton organization Source: UniProtKB
  10. semaphorin-plexin signaling pathway Source: UniProtKB
  11. semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-B1
Gene namesi
Name:Plxnb1
Synonyms:Kiaa0407
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2154238. Plxnb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 14741455Extracellular Reviewed prediction
Add
BLAST
Transmembranei1475 – 149521Helical; Reviewed prediction
Add
BLAST
Topological domaini1496 – 2119624Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. intracellular Source: InterPro
  3. semaphorin receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 21192100Plexin-B1
PRO_0000024672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi79 ↔ 88 By similarity
Disulfide bondi111 ↔ 119 By similarity
Disulfide bondi252 ↔ 377 By similarity
Disulfide bondi268 ↔ 322 By similarity
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi340 ↔ 364 By similarity
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi482 ↔ 499 By similarity
Disulfide bondi488 ↔ 533 By similarity
Disulfide bondi491 ↔ 508 By similarity
Disulfide bondi502 ↔ 514 By similarity
Glycosylationi543 – 5431N-linked (GlcNAc...)1 Publication
Disulfide bondi570 ↔ 588 By similarity
Glycosylationi1251 – 12511N-linked (GlcNAc...)1 Publication
Glycosylationi1314 – 13141N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding By similarity.
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8CJH3.
PaxDbiQ8CJH3.
PRIDEiQ8CJH3.

PTM databases

PhosphoSiteiQ8CJH3.

Expressioni

Tissue specificityi

Detected in brain, heart, lung, liver, kidney, stomach, testis, uterus and placenta.1 Publication

Gene expression databases

ArrayExpressiQ8CJH3.
BgeeiQ8CJH3.
CleanExiMM_PLXNB1.
GenevestigatoriQ8CJH3.

Interactioni

Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Interacts with RRAS, ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, RHOD, NRP1 and NRP2 By similarity. Binds PLXNA1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef11Q68FM75EBI-2637650,EBI-2365869
Arhgef12Q8R4H22EBI-2637650,EBI-8046267

Protein-protein interaction databases

IntActiQ8CJH3. 4 interactions.
MINTiMINT-1791147.

Structurei

3D structure databases

ProteinModelPortaliQ8CJH3.
SMRiQ8CJH3. Positions 25-533, 1544-2113.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 479460Sema
Add
BLAST
Domaini1068 – 115891IPT/TIG 1
Add
BLAST
Domaini1160 – 124788IPT/TIG 2
Add
BLAST
Domaini1250 – 1359110IPT/TIG 3
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1492 – 152332 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi678 – 835158Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the plexin family.
Contains 3 IPT/TIG domains.
Contains 1 Sema domain.

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254546.
GeneTreeiENSGT00600000084313.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiQ8CJH3.
KOiK06821.
OMAiGVMCPSP.
OrthoDBiEOG7Q8CM9.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJH3-1 [UniParc]FASTAAdd to Basket

« Hide

MSVLGPVLLQ VFWAGCVVTL RSPLPAAFTA NGTHLQHLAR DPTTGTLYVG     50
ATNFLFQLSP GLQLEAVVST GPVNDSRDCL PPVIPDECPQ AQPTNNPNQL 100
LLVSPEALVV CGSVHQGICE LRSLGQIRQL LLRPERPGDT QYVAANDPAV 150
STVGLVAQGL VGEPLLFVGR GYTSRGVGGG IPPITTRALR PPDPQAAFSY 200
EETAKLAVGR LSEYSHHFVS AFVRGASAYF LFLRRDLKAP SRAFRAYVSR 250
VCLQDQHYYS YVELPLACQG GRYGLIQAAA VATSKEVARG DVLFAAFSSV 300
APPTVDWPLS ASTGASGTSV LCAFPLDEVD QLANYTRDAC YTREGRAENG 350
TKVADIAYDV LSDCAQLPVD TPDAFPCGSD HTPSPMVSCV PLEATPILEL 400
PGVQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGRSAA PYSKQSIQPG 450
SPVNRDLTFD GTFEHLYVAT QTTLVKVPVA PCAQHLDCDS CLAHRDPYCG 500
WCVLLGRCSR RSECSRDQGP EQWLWSFQPE LGCLRVVAVS PANISREERR 550
EVFLSVPGLP SLWPGESYFC YFGDQQSPAL LTSSGVMCPS PDPSEAPVLQ 600
RGADHISVNV ELRFGAVVIA STSLSFYDCV AVTASSPSAP CRACVSSRWG 650
CNWCVWQQLC THKASCDAGP MVASQQSPLL PLIPPARDEL TPFPPTVPQT 700
TVTPTPNSFP IEPRAPSTAS DVLPGAKPSR LSLWGPWAGP GPILSPTSTE 750
SPLHEKPLPP DPPTIPGTTV PAPTGLGPST TPEDLLASYP FPSDAAAVSP 800
AEPGPEALPS MVALDQPPGT VPDTTFPGAP GSMKPVLDWL TKGGGELPEA 850
DEWMGGDTPA FSTSTLLSGD GDSAEHEGPP APLILLSSLD YQYDTPGLWE 900
LGEVNQRVSS CPCVETVQGS LLIPVHVERE VQLRGRNLWL FQDGPRSSEC 950
VLELGSREVA VEAQVECAPP PDVWCHIKCQ QHQFSYEALK PELQVGLFLR 1000
WAGGLRVDSA DGLHVVLYDC SVGHGDCSRC QTAMPQYDCV WCEGERPRCV 1050
AREACNEAET VATQCPAPLI HSVDPLTGPI DGGTRVTIRG SNLGQHVQDV 1100
LDMVRVAGVP CAVDAGEYDV SSSLVCITGA SGEEVTGTVA VEVPGRGHGV 1150
SEFSFAYQDP KVHSIFPARG PRAGGTRLTL HGSKLLTGRL EDIRVVVGDQ 1200
PCHLLLEQQS EQLHCETGPY PVPAELPVTV LFGATERRLQ HGQFKYTSDP 1250
NVTSVGPSKS FFSGGREIWV RGQDLDVVQR PRIRVTVVPR QHGQGLAQKQ 1300
HVVPEKFEEP CLVNSSHLLM CRTPALPGPP WDSGVQVEFI LDNMVFDFAA 1350
LSPTPFSYEA DPTLRSLNPE DPSTPFRHKP GSVFSVEGEN LDLAMSKEEV 1400
VAMIGDGPCV VKTLTRNHLY CEPPVEQPLP HPHALREAPD ALPEFTVQMG 1450
NLRFSLGHVQ YDGESPVAFP VAAQVGLGVG TSLLALGVII IVLIYRRKSK 1500
QALRDYKKVQ IQLENLESSV RDRCKKEFTD LMTEMTDLTS DLLGSGIPFL 1550
DYKVYAERVF FPGYRESPLH RDLGVPDSRR PTVEQGLGQL SNLLNSKLFL 1600
TKFIHTLESQ RTFSARDRAY VASLLTVALH GKLEYFTDIL RTLLSDLVAQ 1650
YVAKNPKLML RRTETVVEKL LTNWMSICLY TFVRDSVGEP LYMLFRGIKH 1700
QVDKGPVDSV TGKAKYTLND NRLLREDVEY RPLTLNALLA VGPGAGEAQC 1750
VPVKVLDCDT ISQAKEKMLD QLYKGVPLAQ RPDSCTLDVE WRSGVAGHLI 1800
LSDEDVTSEL QGLWRRLNTL QHYKVPDGAT VALVPCLTKH ILRENQDYVP 1850
GERTPMLEDV DEGGIRPWHL VKPSDEPEPP RPRRGSLRGG ERERAKAIPE 1900
IYLTRLLSMK GTLQKFVDDL FQVILSTSRP VPLAVKYFFD LLDEQAQQHG 1950
ISDQDTIHIW KTNSLPLRFW INIIKNPQFV FDVQTSDNMD AVLLVIAQTF 2000
MDACTLADHK LGRDSPINKL LYARDIPRYK QMVERYYADI RQTVPASDQE 2050
MNSVLAELSR NCSADLGARV ALHELYKYIN KYYDQIITAL EEDGTAQKMQ 2100
LGYRLQQIAA AVENKVTDL 2119
Length:2,119
Mass (Da):231,376
Last modified:July 27, 2011 - v2
Checksum:i08FB5ECD2E6DE342
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361Q → L in BAC22660. 1 Publication
Sequence conflicti1777 – 17771P → L in BAC97943. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072381 mRNA. Translation: BAC22660.1.
AC140383 Genomic DNA. No translation available.
AC174646 Genomic DNA. No translation available.
AK129133 mRNA. Translation: BAC97943.1.
BC043322 mRNA. Translation: AAH43322.1.
CCDSiCCDS23546.1.
RefSeqiNP_766363.2. NM_172775.2.
XP_006512138.1. XM_006512075.1.
XP_006512139.1. XM_006512076.1.
XP_006512140.1. XM_006512077.1.
XP_006512141.1. XM_006512078.1.
XP_006512142.1. XM_006512079.1.
XP_006512143.1. XM_006512080.1.
UniGeneiMm.53862.

Genome annotation databases

EnsembliENSMUST00000072093; ENSMUSP00000071966; ENSMUSG00000053646.
GeneIDi235611.
KEGGimmu:235611.
UCSCiuc009rrz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072381 mRNA. Translation: BAC22660.1 .
AC140383 Genomic DNA. No translation available.
AC174646 Genomic DNA. No translation available.
AK129133 mRNA. Translation: BAC97943.1 .
BC043322 mRNA. Translation: AAH43322.1 .
CCDSi CCDS23546.1.
RefSeqi NP_766363.2. NM_172775.2.
XP_006512138.1. XM_006512075.1.
XP_006512139.1. XM_006512076.1.
XP_006512140.1. XM_006512077.1.
XP_006512141.1. XM_006512078.1.
XP_006512142.1. XM_006512079.1.
XP_006512143.1. XM_006512080.1.
UniGenei Mm.53862.

3D structure databases

ProteinModelPortali Q8CJH3.
SMRi Q8CJH3. Positions 25-533, 1544-2113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CJH3. 4 interactions.
MINTi MINT-1791147.

PTM databases

PhosphoSitei Q8CJH3.

Proteomic databases

MaxQBi Q8CJH3.
PaxDbi Q8CJH3.
PRIDEi Q8CJH3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072093 ; ENSMUSP00000071966 ; ENSMUSG00000053646 .
GeneIDi 235611.
KEGGi mmu:235611.
UCSCi uc009rrz.2. mouse.

Organism-specific databases

CTDi 5364.
MGIi MGI:2154238. Plxnb1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG254546.
GeneTreei ENSGT00600000084313.
HOGENOMi HOG000231376.
HOVERGENi HBG053404.
InParanoidi Q8CJH3.
KOi K06821.
OMAi GVMCPSP.
OrthoDBi EOG7Q8CM9.
TreeFami TF312962.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.

Miscellaneous databases

NextBioi 382789.
PROi Q8CJH3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8CJH3.
Bgeei Q8CJH3.
CleanExi MM_PLXNB1.
Genevestigatori Q8CJH3.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view ]
SMARTi SM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains."
    Usui H., Taniguchi M., Yokomizo T., Shimizu T.
    Biochem. Biophys. Res. Commun. 300:927-931(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PLXNA1.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 913-2119.
    Tissue: Embryonic tail.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1885-2119.
    Tissue: Eye.
  5. "The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways."
    Vodrazka P., Korostylev A., Hirschberg A., Swiercz J.M., Worzfeld T., Deng S., Fazzari P., Tamagnone L., Offermanns S., Kuner R.
    Eur. J. Neurosci. 30:1193-1208(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-543 AND ASN-1251.

Entry informationi

Entry nameiPLXB1_MOUSE
AccessioniPrimary (citable) accession number: Q8CJH3
Secondary accession number(s): E9QKS4, Q6ZQC3, Q80ZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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