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Protein

Zymogen granule membrane protein 16

Gene

Zg16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule membrane protein 16
Short name:
Zymogen granule protein 16
Alternative name(s):
Secretory lectin ZG16
Gene namesi
Name:Zg16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620346. Zg16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Extracellular matrix, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616By similarityAdd
BLAST
Chaini17 – 167151Zymogen granule membrane protein 16PRO_0000017572Add
BLAST

Proteomic databases

PaxDbiQ8CJD3.
PRIDEiQ8CJD3.

Expressioni

Tissue specificityi

Expressed in pancreas, colon, duodenum, and much less in stomach.1 Publication

Gene expression databases

GenevisibleiQ8CJD3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022758.

Structurei

3D structure databases

ProteinModelPortaliQ8CJD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 159136Jacalin-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated
Contains 1 jacalin-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
GeneTreeiENSGT00530000063886.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiQ8CJD3.
OMAiVRYGTVW.
OrthoDBiEOG73FQQ7.
PhylomeDBiQ8CJD3.
TreeFamiTF333440.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAIALLVLL CASASANSIQ SRSSSYSGEY GGKGGKRFSH SGNQLDGPIT
60 70 80 90 100
AIRIRVNRYY IIGLQVRYGT VWSDYVGGNQ GDLEEIFLHP GESVIQVSGK
110 120 130 140 150
YKSYVKQLIF VTDKGRYLPF GKDSGTSFNA VPLHPNTVLR FISGRSGSAI
160
DAISLHWDTY PSHCNTC
Length:167
Mass (Da):18,213
Last modified:March 1, 2003 - v1
Checksum:i5C210CD2C1220CF2
GO

Sequence cautioni

The sequence CAA83059.1 differs from that shown. Reason: Frameshift at position 150. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 834QGDL → RET in CAA83059 (PubMed:7720729).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30584 mRNA. Translation: CAA83059.1. Frameshift.
AB095177 mRNA. Translation: BAC24023.1.
PIRiS42924.
RefSeqiNP_599236.2. NM_134409.2.
UniGeneiRn.10439.

Genome annotation databases

EnsembliENSRNOT00000022758; ENSRNOP00000022758; ENSRNOG00000016857.
GeneIDi171449.
KEGGirno:171449.
UCSCiRGD:620346. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30584 mRNA. Translation: CAA83059.1. Frameshift.
AB095177 mRNA. Translation: BAC24023.1.
PIRiS42924.
RefSeqiNP_599236.2. NM_134409.2.
UniGeneiRn.10439.

3D structure databases

ProteinModelPortaliQ8CJD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022758.

Proteomic databases

PaxDbiQ8CJD3.
PRIDEiQ8CJD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022758; ENSRNOP00000022758; ENSRNOG00000016857.
GeneIDi171449.
KEGGirno:171449.
UCSCiRGD:620346. rat.

Organism-specific databases

CTDi653808.
RGDi620346. Zg16.

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
GeneTreeiENSGT00530000063886.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiQ8CJD3.
OMAiVRYGTVW.
OrthoDBiEOG73FQQ7.
PhylomeDBiQ8CJD3.
TreeFamiTF333440.

Miscellaneous databases

NextBioi622380.
PROiQ8CJD3.

Gene expression databases

GenevisibleiQ8CJD3. RN.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and characterization of a novel 16 kDa protein located in zymogen granules of rat pancreas and goblet cells of the gut."
    Cronshagen U., Voland P., Kern H.-F.
    Eur. J. Cell Biol. 65:366-377(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Wistar.
    Tissue: Pancreas.
  2. "Expression of rat ZG16p in AR42J cells."
    Matsuda Y., Kojima-Aikawa K.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The secretory lectin ZG16p mediates sorting of enzyme proteins to the zymogen granule membrane in pancreatic acinar cells."
    Kleene R., Dartsch H., Kern H.-F.
    Eur. J. Cell Biol. 78:79-90(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZG16_RAT
AccessioniPrimary (citable) accession number: Q8CJD3
Secondary accession number(s): Q63680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.