Q8CJC4 (Q8CJC4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Frizzled-3 protein EMBL AAN14442.1

Gene names

Name:

Fzd3 RGD 628814

Organism

Rattus norvegicus (Rat) EMBL AAN14442.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	666 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FZ (frizzled) domain. SAAS SAAS000539

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS015526
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS000539
Molecular function	Developmental protein SAAS SAAS000539 G-protein coupled receptor SAAS SAAS000539 Receptor Transducer
PTM	Disulfide bond SAAS SAAS000539
Gene Ontology (GO)
Biological process	G-protein signaling, coupled to cGMP nucleotide second messenger Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cell proliferation in midbrain Inferred from Biological aspect of Ancestor. Source: RefGenome commissural neuron axon guidance Inferred from Biological aspect of Ancestor. Source: RefGenome establishment of planar polarity Inferred from Biological aspect of Ancestor. Source: RefGenome facial nucleus development Inferred from Biological aspect of Ancestor. Source: RefGenome gonad development Inferred from Biological aspect of Ancestor. Source: RefGenome inner ear morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome neural tube closure Inferred from Biological aspect of Ancestor. Source: RefGenome vasculature development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	apical part of cell Inferred from Biological aspect of Ancestor. Source: RefGenome axon Inferred from Biological aspect of Ancestor. Source: RefGenome cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome dendrite Inferred from Biological aspect of Ancestor. Source: RefGenome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuron projection membrane Inferred from Biological aspect of Ancestor. Source: RefGenome neuronal cell body Inferred from Biological aspect of Ancestor. Source: RefGenome presynaptic active zone Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW PDZ domain binding Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt-activated receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt-protein binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8CJC4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 4681AE5869B500E4	FASTA	666	76,168
	10 20 30 40 50 60 MAVSWIVFYL WLLTVFLGQI GGHSLFSCEP ITLRMCQDLP YNTTFMPNLL NHYDQQTAAL 70 80 90 100 110 120 AMEPFHPMVN LDCSRDFRPF LCALYAPICM EYGRVTLPCR RLCQRAYSEC SKLMEMFGVP 130 140 150 160 170 180 WPEDMECSRF PDCDEPYPRL VDLNLVGDPT EGAPVAVQRD YGFWCPRELK IDPDLGYSFL 190 200 210 220 230 240 HVRDCSPPCP NMYFRREELS FARYFIGLIS IICLSATLVT FLTFLIDVTR FRYPERPIIF 250 260 270 280 290 300 YAVCYMMVSL IFFIGFLLED RVACNASSPA QYKASTVTQG SHNKACTMLF MVLYFFTMAG 310 320 330 340 350 360 SVWWVILTIT WFLAAVPKWG SEAIEKKALL FHASAWGIPG TLTIILLAMN KIEGDNISGV 370 380 390 400 410 420 CFVGLYDVDA LRYFVLAPLC LYVVVGVSLL LAGIISLNRV RIEIPLEKEN QDKLVKFMIR 430 440 450 460 470 480 IGVFSILYLV PLLVVIGCYF YEQAYRGIWE TTWIQERCRE YHIPCPYQVT QMSRPDLILF 490 500 510 520 530 540 LMKYLMALIV GIPSIFWVGS KKTCFEWASF FHGRKKKETV NESRQVLQEP DFAQSLLRDP 550 560 570 580 590 600 NTPIIRKSRG TSTQGTSTHA SSTQLAMVDD QRSKAGSVHS KVSSYHGSLH RSRDGRYTPC 610 620 630 640 650 660 SYRGMEERLP HGSMSRLTDH SRHSSSHRLN EQSRHSSIRD LSNNPMTHIT HGTSMNRVIE EDGTSA

References

[1]	"Identification and characterization of frizzled-3 protein: decrease in rat frontal cortex after antidepressant or electroconvulsive treatment." Yamada M. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAN14442.1. Tissue: Frontal cortex EMBL AAN14442.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF323956 mRNA. Translation: AAN14442.1.
IPI	IPI00194675.
RefSeq	NP_703204.1. NM_153474.1.
UniGene	Rn.178695.
3D structure databases
HSSP	HSSP built from PDB template 1IJY based on UniProtKB Q61091.
ProteinModelPortal	Q8CJC4.
ModBase	Search...
PTM databases
PhosphoSite	Q8CJC4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	266715.
KEGG	rno:266715.
Organism-specific databases
CTD	7976.
RGD	628814. Fzd3.
Phylogenomic databases
HOVERGEN	HBG006977.
Gene expression databases
Genevestigator	Q8CJC4.
Family and domain databases
InterPro	IPR000539. Frizzled. IPR015526. Frizzled-related. IPR020067. Frizzled_dom. IPR017981. GPCR_2-like. [Graphical view]
Gene3D	G3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
KO	K02329.
PANTHER	PTHR11309. Fz_related. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	624550.

Entry information

Entry name

Q8CJC4_RAT

Accession

Primary (citable) accession number: Q8CJC4

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)