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Protein

Ras association domain-containing protein 8

Gene

Rassf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 8
Alternative name(s):
Carcinoma-associated protein HOJ-1 homolog
Gene namesi
Name:Rassf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1918573. Rassf8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Ras association domain-containing protein 8PRO_0000089841Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CJ96.
PaxDbiQ8CJ96.
PRIDEiQ8CJ96.

PTM databases

iPTMnetiQ8CJ96.
PhosphoSiteiQ8CJ96.

Expressioni

Gene expression databases

BgeeiQ8CJ96.
ExpressionAtlasiQ8CJ96. baseline and differential.
GenevisibleiQ8CJ96. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032388.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ96.
SMRiQ8CJ96. Positions 1-83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 301121Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1574. Eukaryota.
ENOG410XPWB. LUCA.
GeneTreeiENSGT00530000063648.
HOGENOMiHOG000013031.
HOVERGENiHBG050971.
InParanoidiQ8CJ96.
KOiK09855.
OMAiAQIQTME.
OrthoDBiEOG70GMG6.
PhylomeDBiQ8CJ96.
TreeFamiTF318385.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CJ96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKVWVDGV QRIVCGVTEV TTCQEVVIAL AQAIGRTGRY TLIEKWRDTE
60 70 80 90 100
RHLAPHENPI VSLNKWGQYA SDVQLILRRT GPSLSERPTS DSVARIPERT
110 120 130 140 150
LYRQSLPPLA KLRPQADKSI RRREPKRKSL TFTGGAKGLT DIFGKGKETE
160 170 180 190 200
FRQKVLSNCR ATAEELKRLI RLQTGKLQAI EKQLESSEAE IRFWEQKYSC
210 220 230 240 250
SLEEEIVRLE QRIKRNDVEI EEEEFWENEL QIEQENEKQL QDQLEEIRQK
260 270 280 290 300
VTDCEGRLKD YLAQIHTMES GLQAEKLHRE VQEAQVNEEE VKGKIEKVKG
310 320 330 340 350
EMDLQGQQSL RLENGIRAVE RSLGQATKRL QDKEQELEQL TKELRQVNLQ
360 370 380 390 400
QFIQQTGTKV TVLPAEPTEI EASQADIETE APFQSGSLKR PGSSRQLPSN
410
LRILQNPVSS GFNPEGIYV
Length:419
Mass (Da):48,103
Last modified:March 1, 2003 - v1
Checksum:iA809CFFE0AE62597
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731Q → E in BAB30637 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424737 mRNA. Translation: AAN28310.1.
BC115779 mRNA. Translation: AAI15780.1.
BC117546 mRNA. Translation: AAI17547.1.
AK017214 mRNA. Translation: BAB30637.1.
AK031980 mRNA. Translation: BAC27637.1.
CCDSiCCDS20696.1.
RefSeqiNP_082036.1. NM_027760.2.
XP_011239900.1. XM_011241598.1.
XP_011239901.1. XM_011241599.1.
XP_011239902.1. XM_011241600.1.
UniGeneiMm.158669.
Mm.444985.

Genome annotation databases

EnsembliENSMUST00000032388; ENSMUSP00000032388; ENSMUSG00000030259.
ENSMUST00000111704; ENSMUSP00000107333; ENSMUSG00000030259.
GeneIDi71323.
KEGGimmu:71323.
UCSCiuc009err.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424737 mRNA. Translation: AAN28310.1.
BC115779 mRNA. Translation: AAI15780.1.
BC117546 mRNA. Translation: AAI17547.1.
AK017214 mRNA. Translation: BAB30637.1.
AK031980 mRNA. Translation: BAC27637.1.
CCDSiCCDS20696.1.
RefSeqiNP_082036.1. NM_027760.2.
XP_011239900.1. XM_011241598.1.
XP_011239901.1. XM_011241599.1.
XP_011239902.1. XM_011241600.1.
UniGeneiMm.158669.
Mm.444985.

3D structure databases

ProteinModelPortaliQ8CJ96.
SMRiQ8CJ96. Positions 1-83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032388.

PTM databases

iPTMnetiQ8CJ96.
PhosphoSiteiQ8CJ96.

Proteomic databases

MaxQBiQ8CJ96.
PaxDbiQ8CJ96.
PRIDEiQ8CJ96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032388; ENSMUSP00000032388; ENSMUSG00000030259.
ENSMUST00000111704; ENSMUSP00000107333; ENSMUSG00000030259.
GeneIDi71323.
KEGGimmu:71323.
UCSCiuc009err.1. mouse.

Organism-specific databases

CTDi11228.
MGIiMGI:1918573. Rassf8.

Phylogenomic databases

eggNOGiKOG1574. Eukaryota.
ENOG410XPWB. LUCA.
GeneTreeiENSGT00530000063648.
HOGENOMiHOG000013031.
HOVERGENiHBG050971.
InParanoidiQ8CJ96.
KOiK09855.
OMAiAQIQTME.
OrthoDBiEOG70GMG6.
PhylomeDBiQ8CJ96.
TreeFamiTF318385.

Miscellaneous databases

NextBioi333541.
PROiQ8CJ96.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CJ96.
ExpressionAtlasiQ8CJ96. baseline and differential.
GenevisibleiQ8CJ96. MM.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wang M., Futamura M., Zhang Z., Wang Y., You M.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-419.
    Strain: C57BL/6J.
    Tissue: Intestine and Medulla oblongata.

Entry informationi

Entry nameiRASF8_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ96
Secondary accession number(s): Q149Q5, Q8CCW4, Q9CU91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.