Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CD209 antigen-like protein B

Gene

Cd209b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi285 – 2851CalciumBy similarity
Metal bindingi287 – 2871CalciumBy similarity
Metal bindingi289 – 2891Calcium; via carbonyl oxygenBy similarity
Metal bindingi292 – 2921CalciumBy similarity
Metal bindingi303 – 3031CalciumBy similarity
Metal bindingi304 – 3041CalciumBy similarity

GO - Molecular functioni

  • (1->3)-beta-D-glucan binding Source: MGI
  • mannose binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • polysaccharide binding Source: MGI

GO - Biological processi

  • detection of bacterium Source: MGI
  • detection of yeast Source: MGI
  • endocytosis Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of tumor necrosis factor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin, Mannose-binding, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5621575. CD209 (DC-SIGN) signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
CD209 antigen-like protein B
Alternative name(s):
DC-SIGN-related protein 1
Short name:
DC-SIGNR1
OtB7
CD_antigen: CD209
Gene namesi
Name:Cd209b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916415. Cd209b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini74 – 325252ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325CD209 antigen-like protein BPRO_0000046605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi195 ↔ 206PROSITE-ProRule annotation
Disulfide bondi223 ↔ 315PROSITE-ProRule annotation
Disulfide bondi294 ↔ 307PROSITE-ProRule annotation
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8CJ91.
MaxQBiQ8CJ91.
PaxDbiQ8CJ91.
PRIDEiQ8CJ91.

PTM databases

PhosphoSiteiQ8CJ91.

Expressioni

Tissue specificityi

Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer.1 Publication

Gene expression databases

BgeeiQ8CJ91.
CleanExiMM_CD209B.
ExpressionAtlasiQ8CJ91. baseline and differential.
GenevisibleiQ8CJ91. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-61328N.
STRINGi10090.ENSMUSP00000081104.

Structurei

Secondary structure

1
325
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi200 – 2023Combined sources
Beta strandi205 – 2095Combined sources
Helixi216 – 2249Combined sources
Turni225 – 2273Combined sources
Helixi236 – 24914Combined sources
Beta strandi252 – 26110Combined sources
Beta strandi264 – 2674Combined sources
Helixi275 – 2806Combined sources
Turni289 – 2913Combined sources
Beta strandi294 – 2985Combined sources
Beta strandi301 – 3055Combined sources
Beta strandi311 – 3188Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHGX-ray1.87A/B/C191-325[»]
D190-325[»]
4C9FX-ray2.60A/B/C/D191-323[»]
4CAJX-ray2.19A/B/C/D191-325[»]
ProteinModelPortaliQ8CJ91.
SMRiQ8CJ91. Positions 141-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 316116C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3Z. Eukaryota.
ENOG410YSMB. LUCA.
GeneTreeiENSGT00760000118924.
HOVERGENiHBG050992.
InParanoidiQ8CJ91.
KOiK06563.
OMAiNDSKCEL.
OrthoDBiEOG7J180R.
PhylomeDBiQ8CJ91.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CJ91-1) [UniParc]FASTAAdd to basket

Also known as: alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSTEAKMQ PLSSMDDDEL MVSGSRYSIK SSRLRPNSGI KCLAGCSGHS
60 70 80 90 100
QVPLVLQLLS FLFLAGLLLI ILFQVSKTPN TERQKEQEKI LQELTQLTDE
110 120 130 140 150
LTSRIPISQG KNESMQAKIT EQLMQLKTEL LSRIPIFQGQ NESIQEKISE
160 170 180 190 200
QLMQLKAELL SKISSFPVKD DSKQEKIYQQ LVQMKTELFR LCRLCPWDWT
210 220 230 240 250
FLLGNCYFFS KSQRNWNDAV TACKEVKAQL VIINSDEEQT FLQQTSKAKG
260 270 280 290 300
PTWMGLSDLK KEATWLWVDG STLSSRFQKY WNRGEPNNIG EEDCVEFAGD
310 320
GWNDSKCELK KFWICKKSAT PCTEG
Length:325
Mass (Da):37,112
Last modified:April 13, 2004 - v2
Checksum:i9C9388407C247CA4
GO
Isoform 2 (identifier: Q8CJ91-2) [UniParc]FASTAAdd to basket

Also known as: beta, TM-less

The sequence of this isoform differs from the canonical sequence as follows:
     45-74: Missing.

Show »
Length:295
Mass (Da):33,889
Checksum:iA491F7D3551A91D0
GO
Isoform 3 (identifier: Q8CJ91-3) [UniParc]FASTAAdd to basket

Also known as: gamma

The sequence of this isoform differs from the canonical sequence as follows:
     45-74: Missing.
     275-275: S → SSRPRHAPISRGRPIYNMHSGR

Show »
Length:316
Mass (Da):36,316
Checksum:iE43D6B00F58AA784
GO
Isoform 4 (identifier: Q8CJ91-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Show »
Length:142
Mass (Da):16,471
Checksum:i0CBB36A383D887EF
GO

Sequence cautioni

The sequence BAB25166.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711I → V in AAN75588 (PubMed:12137941).Curated
Sequence conflicti87 – 871Q → P in AAN75589 (PubMed:12137941).Curated
Sequence conflicti112 – 1121N → D in AAN75586 (PubMed:12137941).Curated
Sequence conflicti124 – 1241M → T in AAN75585 (PubMed:12137941).Curated
Sequence conflicti138 – 1381Q → R in AAN75588 (PubMed:12137941).Curated
Sequence conflicti163 – 1631I → V in AAN75586 (PubMed:12137941).Curated
Sequence conflicti226 – 2261V → A in AAN75588 (PubMed:12137941).Curated
Sequence conflicti229 – 2291Q → R in AAN75589 (PubMed:12137941).Curated
Sequence conflicti232 – 2321I → T in AAN75587 (PubMed:12137941).Curated
Sequence conflicti235 – 2351S → G in AAN75587 (PubMed:12137941).Curated
Sequence conflicti267 – 2671W → R in AAN75589 (PubMed:12137941).Curated
Sequence conflicti308 – 3081E → G in AAN75585 (PubMed:12137941).Curated
Sequence conflicti312 – 3121F → L in AAN75597 (PubMed:12137941).Curated
Sequence conflicti321 – 3255PCTEG → HA in AAN75590 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75585 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75586 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75587 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75588 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75589 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75591 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75592 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75593 (PubMed:12137941).Curated
Sequence conflicti323 – 3253TEG → P in AAN75594 (PubMed:12137941).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 183183Missing in isoform 4. 1 PublicationVSP_010068Add
BLAST
Alternative sequencei45 – 7430Missing in isoform 2 and isoform 3. 2 PublicationsVSP_010069Add
BLAST
Alternative sequencei275 – 2751S → SSRPRHAPISRGRPIYNMHS GR in isoform 3. 1 PublicationVSP_010070

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373409 mRNA. Translation: AAL13235.1.
AF374471 mRNA. Translation: AAL27540.1.
AF424790 mRNA. Translation: AAN75585.1.
AF424791 mRNA. Translation: AAN75586.1.
AF424792 mRNA. Translation: AAN75587.1.
AF424793 mRNA. Translation: AAN75588.1.
AF424794 mRNA. Translation: AAN75589.1.
AF424795 mRNA. Translation: AAN75590.1.
AF424797 mRNA. Translation: AAN75592.1.
AF424798 mRNA. Translation: AAN75593.1.
AF424796 mRNA. Translation: AAN75591.1.
AF424799 mRNA. Translation: AAN75594.1.
AF424800 mRNA. Translation: AAN75595.1.
AF424801 mRNA. Translation: AAN75596.1.
AF424802 mRNA. Translation: AAN75597.1.
AF422108 mRNA. Translation: AAN31450.1.
AK007656 mRNA. Translation: BAB25166.1. Different initiation.
CCDSiCCDS22076.1. [Q8CJ91-2]
CCDS22077.1. [Q8CJ91-1]
CCDS72089.1. [Q8CJ91-3]
RefSeqiNP_001032889.3. NM_001037800.3. [Q8CJ91-2]
NP_001274140.1. NM_001287211.1. [Q8CJ91-3]
NP_081248.4. NM_026972.5. [Q8CJ91-1]
UniGeneiMm.175163.

Genome annotation databases

EnsembliENSMUST00000084086; ENSMUSP00000081104; ENSMUSG00000065987. [Q8CJ91-1]
ENSMUST00000171635; ENSMUSP00000126070; ENSMUSG00000065987. [Q8CJ91-2]
ENSMUST00000188386; ENSMUSP00000140695; ENSMUSG00000065987. [Q8CJ91-3]
GeneIDi69165.
KEGGimmu:69165.
UCSCiuc009ksu.2. mouse. [Q8CJ91-1]
uc009ksv.2. mouse. [Q8CJ91-2]
uc012fyw.2. mouse. [Q8CJ91-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

SIGNR1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373409 mRNA. Translation: AAL13235.1.
AF374471 mRNA. Translation: AAL27540.1.
AF424790 mRNA. Translation: AAN75585.1.
AF424791 mRNA. Translation: AAN75586.1.
AF424792 mRNA. Translation: AAN75587.1.
AF424793 mRNA. Translation: AAN75588.1.
AF424794 mRNA. Translation: AAN75589.1.
AF424795 mRNA. Translation: AAN75590.1.
AF424797 mRNA. Translation: AAN75592.1.
AF424798 mRNA. Translation: AAN75593.1.
AF424796 mRNA. Translation: AAN75591.1.
AF424799 mRNA. Translation: AAN75594.1.
AF424800 mRNA. Translation: AAN75595.1.
AF424801 mRNA. Translation: AAN75596.1.
AF424802 mRNA. Translation: AAN75597.1.
AF422108 mRNA. Translation: AAN31450.1.
AK007656 mRNA. Translation: BAB25166.1. Different initiation.
CCDSiCCDS22076.1. [Q8CJ91-2]
CCDS22077.1. [Q8CJ91-1]
CCDS72089.1. [Q8CJ91-3]
RefSeqiNP_001032889.3. NM_001037800.3. [Q8CJ91-2]
NP_001274140.1. NM_001287211.1. [Q8CJ91-3]
NP_081248.4. NM_026972.5. [Q8CJ91-1]
UniGeneiMm.175163.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHGX-ray1.87A/B/C191-325[»]
D190-325[»]
4C9FX-ray2.60A/B/C/D191-323[»]
4CAJX-ray2.19A/B/C/D191-325[»]
ProteinModelPortaliQ8CJ91.
SMRiQ8CJ91. Positions 141-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61328N.
STRINGi10090.ENSMUSP00000081104.

PTM databases

PhosphoSiteiQ8CJ91.

Proteomic databases

EPDiQ8CJ91.
MaxQBiQ8CJ91.
PaxDbiQ8CJ91.
PRIDEiQ8CJ91.

Protocols and materials databases

DNASUi69165.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084086; ENSMUSP00000081104; ENSMUSG00000065987. [Q8CJ91-1]
ENSMUST00000171635; ENSMUSP00000126070; ENSMUSG00000065987. [Q8CJ91-2]
ENSMUST00000188386; ENSMUSP00000140695; ENSMUSG00000065987. [Q8CJ91-3]
GeneIDi69165.
KEGGimmu:69165.
UCSCiuc009ksu.2. mouse. [Q8CJ91-1]
uc009ksv.2. mouse. [Q8CJ91-2]
uc012fyw.2. mouse. [Q8CJ91-3]

Organism-specific databases

CTDi69165.
MGIiMGI:1916415. Cd209b.

Phylogenomic databases

eggNOGiENOG410IS3Z. Eukaryota.
ENOG410YSMB. LUCA.
GeneTreeiENSGT00760000118924.
HOVERGENiHBG050992.
InParanoidiQ8CJ91.
KOiK06563.
OMAiNDSKCEL.
OrthoDBiEOG7J180R.
PhylomeDBiQ8CJ91.
TreeFamiTF333341.

Enzyme and pathway databases

ReactomeiR-MMU-5621575. CD209 (DC-SIGN) signaling.

Miscellaneous databases

NextBioi328746.
PROiQ8CJ91.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CJ91.
CleanExiMM_CD209B.
ExpressionAtlasiQ8CJ91. baseline and differential.
GenevisibleiQ8CJ91. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
  2. "Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR."
    Parent S.A., Zhang T., Chrebet G., Clemas J.A., Figueroa D.J., Ky B., Blevins R.A., Austin C.P., Rosen H.
    Gene 293:33-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Skin and Spleen.
  3. "Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo."
    Geijtenbeek T.B.H., Groot P.C., Nolte M.A., Van Vliet S.J., Gangaram-Panday S.T., Van Duijnhoven G.C.F., Kraal G., Van Oosterhout A.J.M., Van Kooyk Y.
    Blood 100:2908-2916(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/cJ.
    Tissue: Lymph node.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-325 (ISOFORM 1), INTERACTION WITH HIV-1; HIV-2; SIV AND ICAM3.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-325 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Pancreas.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiC209B_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ91
Secondary accession number(s): Q8BGZ0
, Q8BHK7, Q8CJ86, Q8CJ87, Q8CJ88, Q8CJ89, Q8CJ90, Q8CJ92, Q8CJ93, Q8CJ94, Q91ZW4, Q91ZX0, Q9D8V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: March 16, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vitro, is a receptor for HIV-1, HIV-2 and SIV, but does not transmit virus to permissive T-cells under the conditions tested.

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.