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Protein

CD209 antigen-like protein B

Gene

Cd209b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi285CalciumBy similarity1
Metal bindingi287CalciumBy similarity1
Metal bindingi289Calcium; via carbonyl oxygenBy similarity1
Metal bindingi292CalciumBy similarity1
Metal bindingi303CalciumBy similarity1
Metal bindingi304CalciumBy similarity1

GO - Molecular functioni

  • (1->3)-beta-D-glucan binding Source: MGI
  • mannose binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • polysaccharide binding Source: MGI

GO - Biological processi

  • detection of bacterium Source: MGI
  • detection of yeast Source: MGI
  • endocytosis Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of tumor necrosis factor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin, Mannose-binding, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5621575. CD209 (DC-SIGN) signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
CD209 antigen-like protein B
Alternative name(s):
DC-SIGN-related protein 1
Short name:
DC-SIGNR1
OtB7
CD_antigen: CD209
Gene namesi
Name:Cd209b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916415. Cd209b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini74 – 325ExtracellularSequence analysisAdd BLAST252

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466051 – 325CD209 antigen-like protein BAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi195 ↔ 206PROSITE-ProRule annotation
Disulfide bondi223 ↔ 315PROSITE-ProRule annotation
Disulfide bondi294 ↔ 307PROSITE-ProRule annotation
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CJ91.
PRIDEiQ8CJ91.

PTM databases

PhosphoSitePlusiQ8CJ91.

Expressioni

Tissue specificityi

Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer.1 Publication

Gene expression databases

BgeeiENSMUSG00000065987.
CleanExiMM_CD209B.
ExpressionAtlasiQ8CJ91. baseline and differential.
GenevisibleiQ8CJ91. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-61328N.
STRINGi10090.ENSMUSP00000081104.

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi200 – 202Combined sources3
Beta strandi205 – 209Combined sources5
Helixi216 – 224Combined sources9
Turni225 – 227Combined sources3
Helixi236 – 249Combined sources14
Beta strandi252 – 261Combined sources10
Beta strandi264 – 267Combined sources4
Helixi275 – 280Combined sources6
Turni289 – 291Combined sources3
Beta strandi294 – 298Combined sources5
Beta strandi301 – 305Combined sources5
Beta strandi311 – 318Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHGX-ray1.87A/B/C191-325[»]
D190-325[»]
4C9FX-ray2.60A/B/C/D191-323[»]
4CAJX-ray2.19A/B/C/D191-325[»]
ProteinModelPortaliQ8CJ91.
SMRiQ8CJ91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 316C-type lectinPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3Z. Eukaryota.
ENOG410YSMB. LUCA.
GeneTreeiENSGT00760000118924.
HOVERGENiHBG050992.
InParanoidiQ8CJ91.
KOiK06563.
OMAiNDSKCEL.
OrthoDBiEOG091G0G9W.
PhylomeDBiQ8CJ91.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CJ91-1) [UniParc]FASTAAdd to basket
Also known as: alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSTEAKMQ PLSSMDDDEL MVSGSRYSIK SSRLRPNSGI KCLAGCSGHS
60 70 80 90 100
QVPLVLQLLS FLFLAGLLLI ILFQVSKTPN TERQKEQEKI LQELTQLTDE
110 120 130 140 150
LTSRIPISQG KNESMQAKIT EQLMQLKTEL LSRIPIFQGQ NESIQEKISE
160 170 180 190 200
QLMQLKAELL SKISSFPVKD DSKQEKIYQQ LVQMKTELFR LCRLCPWDWT
210 220 230 240 250
FLLGNCYFFS KSQRNWNDAV TACKEVKAQL VIINSDEEQT FLQQTSKAKG
260 270 280 290 300
PTWMGLSDLK KEATWLWVDG STLSSRFQKY WNRGEPNNIG EEDCVEFAGD
310 320
GWNDSKCELK KFWICKKSAT PCTEG
Length:325
Mass (Da):37,112
Last modified:April 13, 2004 - v2
Checksum:i9C9388407C247CA4
GO
Isoform 2 (identifier: Q8CJ91-2) [UniParc]FASTAAdd to basket
Also known as: beta, TM-less

The sequence of this isoform differs from the canonical sequence as follows:
     45-74: Missing.

Show »
Length:295
Mass (Da):33,889
Checksum:iA491F7D3551A91D0
GO
Isoform 3 (identifier: Q8CJ91-3) [UniParc]FASTAAdd to basket
Also known as: gamma

The sequence of this isoform differs from the canonical sequence as follows:
     45-74: Missing.
     275-275: S → SSRPRHAPISRGRPIYNMHSGR

Show »
Length:316
Mass (Da):36,316
Checksum:iE43D6B00F58AA784
GO
Isoform 4 (identifier: Q8CJ91-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Show »
Length:142
Mass (Da):16,471
Checksum:i0CBB36A383D887EF
GO

Sequence cautioni

The sequence BAB25166 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71I → V in AAN75588 (PubMed:12137941).Curated1
Sequence conflicti87Q → P in AAN75589 (PubMed:12137941).Curated1
Sequence conflicti112N → D in AAN75586 (PubMed:12137941).Curated1
Sequence conflicti124M → T in AAN75585 (PubMed:12137941).Curated1
Sequence conflicti138Q → R in AAN75588 (PubMed:12137941).Curated1
Sequence conflicti163I → V in AAN75586 (PubMed:12137941).Curated1
Sequence conflicti226V → A in AAN75588 (PubMed:12137941).Curated1
Sequence conflicti229Q → R in AAN75589 (PubMed:12137941).Curated1
Sequence conflicti232I → T in AAN75587 (PubMed:12137941).Curated1
Sequence conflicti235S → G in AAN75587 (PubMed:12137941).Curated1
Sequence conflicti267W → R in AAN75589 (PubMed:12137941).Curated1
Sequence conflicti308E → G in AAN75585 (PubMed:12137941).Curated1
Sequence conflicti312F → L in AAN75597 (PubMed:12137941).Curated1
Sequence conflicti321 – 325PCTEG → HA in AAN75590 (PubMed:12137941).Curated5
Sequence conflicti323 – 325TEG → P in AAN75585 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75586 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75587 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75588 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75589 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75591 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75592 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75593 (PubMed:12137941).Curated3
Sequence conflicti323 – 325TEG → P in AAN75594 (PubMed:12137941).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0100681 – 183Missing in isoform 4. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_01006945 – 74Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_010070275S → SSRPRHAPISRGRPIYNMHS GR in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373409 mRNA. Translation: AAL13235.1.
AF374471 mRNA. Translation: AAL27540.1.
AF424790 mRNA. Translation: AAN75585.1.
AF424791 mRNA. Translation: AAN75586.1.
AF424792 mRNA. Translation: AAN75587.1.
AF424793 mRNA. Translation: AAN75588.1.
AF424794 mRNA. Translation: AAN75589.1.
AF424795 mRNA. Translation: AAN75590.1.
AF424797 mRNA. Translation: AAN75592.1.
AF424798 mRNA. Translation: AAN75593.1.
AF424796 mRNA. Translation: AAN75591.1.
AF424799 mRNA. Translation: AAN75594.1.
AF424800 mRNA. Translation: AAN75595.1.
AF424801 mRNA. Translation: AAN75596.1.
AF424802 mRNA. Translation: AAN75597.1.
AF422108 mRNA. Translation: AAN31450.1.
AK007656 mRNA. Translation: BAB25166.1. Different initiation.
CCDSiCCDS22076.1. [Q8CJ91-2]
CCDS22077.1. [Q8CJ91-1]
CCDS72089.1. [Q8CJ91-3]
RefSeqiNP_001032889.3. NM_001037800.3. [Q8CJ91-2]
NP_001274140.1. NM_001287211.1. [Q8CJ91-3]
NP_081248.4. NM_026972.5. [Q8CJ91-1]
UniGeneiMm.175163.

Genome annotation databases

EnsembliENSMUST00000084086; ENSMUSP00000081104; ENSMUSG00000065987. [Q8CJ91-1]
ENSMUST00000171635; ENSMUSP00000126070; ENSMUSG00000065987. [Q8CJ91-2]
ENSMUST00000188386; ENSMUSP00000140695; ENSMUSG00000065987. [Q8CJ91-3]
GeneIDi69165.
KEGGimmu:69165.
UCSCiuc009ksu.2. mouse. [Q8CJ91-1]
uc009ksv.2. mouse. [Q8CJ91-2]
uc012fyw.2. mouse. [Q8CJ91-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

SIGNR1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373409 mRNA. Translation: AAL13235.1.
AF374471 mRNA. Translation: AAL27540.1.
AF424790 mRNA. Translation: AAN75585.1.
AF424791 mRNA. Translation: AAN75586.1.
AF424792 mRNA. Translation: AAN75587.1.
AF424793 mRNA. Translation: AAN75588.1.
AF424794 mRNA. Translation: AAN75589.1.
AF424795 mRNA. Translation: AAN75590.1.
AF424797 mRNA. Translation: AAN75592.1.
AF424798 mRNA. Translation: AAN75593.1.
AF424796 mRNA. Translation: AAN75591.1.
AF424799 mRNA. Translation: AAN75594.1.
AF424800 mRNA. Translation: AAN75595.1.
AF424801 mRNA. Translation: AAN75596.1.
AF424802 mRNA. Translation: AAN75597.1.
AF422108 mRNA. Translation: AAN31450.1.
AK007656 mRNA. Translation: BAB25166.1. Different initiation.
CCDSiCCDS22076.1. [Q8CJ91-2]
CCDS22077.1. [Q8CJ91-1]
CCDS72089.1. [Q8CJ91-3]
RefSeqiNP_001032889.3. NM_001037800.3. [Q8CJ91-2]
NP_001274140.1. NM_001287211.1. [Q8CJ91-3]
NP_081248.4. NM_026972.5. [Q8CJ91-1]
UniGeneiMm.175163.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHGX-ray1.87A/B/C191-325[»]
D190-325[»]
4C9FX-ray2.60A/B/C/D191-323[»]
4CAJX-ray2.19A/B/C/D191-325[»]
ProteinModelPortaliQ8CJ91.
SMRiQ8CJ91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61328N.
STRINGi10090.ENSMUSP00000081104.

PTM databases

PhosphoSitePlusiQ8CJ91.

Proteomic databases

PaxDbiQ8CJ91.
PRIDEiQ8CJ91.

Protocols and materials databases

DNASUi69165.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084086; ENSMUSP00000081104; ENSMUSG00000065987. [Q8CJ91-1]
ENSMUST00000171635; ENSMUSP00000126070; ENSMUSG00000065987. [Q8CJ91-2]
ENSMUST00000188386; ENSMUSP00000140695; ENSMUSG00000065987. [Q8CJ91-3]
GeneIDi69165.
KEGGimmu:69165.
UCSCiuc009ksu.2. mouse. [Q8CJ91-1]
uc009ksv.2. mouse. [Q8CJ91-2]
uc012fyw.2. mouse. [Q8CJ91-3]

Organism-specific databases

CTDi69165.
MGIiMGI:1916415. Cd209b.

Phylogenomic databases

eggNOGiENOG410IS3Z. Eukaryota.
ENOG410YSMB. LUCA.
GeneTreeiENSGT00760000118924.
HOVERGENiHBG050992.
InParanoidiQ8CJ91.
KOiK06563.
OMAiNDSKCEL.
OrthoDBiEOG091G0G9W.
PhylomeDBiQ8CJ91.
TreeFamiTF333341.

Enzyme and pathway databases

ReactomeiR-MMU-5621575. CD209 (DC-SIGN) signaling.

Miscellaneous databases

PROiQ8CJ91.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000065987.
CleanExiMM_CD209B.
ExpressionAtlasiQ8CJ91. baseline and differential.
GenevisibleiQ8CJ91. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC209B_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ91
Secondary accession number(s): Q8BGZ0
, Q8BHK7, Q8CJ86, Q8CJ87, Q8CJ88, Q8CJ89, Q8CJ90, Q8CJ92, Q8CJ93, Q8CJ94, Q91ZW4, Q91ZX0, Q9D8V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vitro, is a receptor for HIV-1, HIV-2 and SIV, but does not transmit virus to permissive T-cells under the conditions tested.

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.