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Protein
Submitted name:

TBX3

Gene

Tbx3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. anterior/posterior axis specification, embryo Source: MGI
  2. atrioventricular bundle cell differentiation Source: MGI
  3. blood vessel development Source: MGI
  4. branching involved in mammary gland duct morphogenesis Source: MGI
  5. cardiac muscle cell differentiation Source: MGI
  6. cardiac muscle cell fate commitment Source: MGI
  7. cell aging Source: MGI
  8. cellular senescence Source: MGI
  9. embryonic digit morphogenesis Source: MGI
  10. embryonic forelimb morphogenesis Source: MGI
  11. embryonic heart tube development Source: MGI
  12. embryonic hindlimb morphogenesis Source: MGI
  13. female genitalia development Source: MGI
  14. follicle-stimulating hormone secretion Source: MGI
  15. forelimb morphogenesis Source: MGI
  16. heart looping Source: MGI
  17. heart morphogenesis Source: MGI
  18. in utero embryonic development Source: MGI
  19. limbic system development Source: MGI
  20. limb morphogenesis Source: MGI
  21. luteinizing hormone secretion Source: MGI
  22. male genitalia development Source: MGI
  23. mammary gland development Source: MGI
  24. mammary placode formation Source: MGI
  25. mesoderm morphogenesis Source: MGI
  26. negative regulation of apoptotic process Source: MGI
  27. negative regulation of epithelial cell differentiation Source: MGI
  28. negative regulation of myoblast differentiation Source: MGI
  29. negative regulation of transcription, DNA-templated Source: MGI
  30. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  31. organ morphogenesis Source: MGI
  32. outflow tract morphogenesis Source: MGI
  33. palate development Source: MGI
  34. positive regulation of cell cycle Source: MGI
  35. positive regulation of cell proliferation Source: MGI
  36. positive regulation of stem cell proliferation Source: MGI
  37. positive regulation of transcription, DNA-templated Source: MGI
  38. regulation of cell proliferation Source: MGI
  39. sinoatrial node cell development Source: MGI
  40. skeletal system development Source: MGI
  41. specification of organ position Source: MGI
  42. stem cell maintenance Source: MGI
  43. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TBX3Imported
Gene namesi
Name:Tbx3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98495. Tbx3.

Subcellular locationi

Nucleus SAAS annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8CJ82.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018748.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains T-box DNA-binding domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG004599.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8CJ82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EMVITKSGRR MFPPFKVRCS GLDKKAKYIL LMDIIAADDC RYKFHNSRWM
60 70 80 90 100
VAGKADPEMP KRMYIHPDSP ATGEQWMSKV VTFHKLKLTN NISDKHGFTI
110 120 130 140 150
LNSMHKYQPR FHIVRANDIL KLPYSTFRTY LFPETEFIAV TAYQNDKITQ
160
LKIDNNPFAK GFRDIGHC
Length:168
Mass (Da):19,634
Last modified:March 1, 2003 - v1
Checksum:i914EA2F26358E5BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei168 – 1681Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF429310 mRNA. Translation: AAN37692.1.
UniGeneiMm.219139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF429310 mRNA. Translation: AAN37692.1.
UniGeneiMm.219139.

3D structure databases

ProteinModelPortaliQ8CJ82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018748.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98495. Tbx3.

Phylogenomic databases

HOVERGENiHBG004599.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8CJ82.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development."
    Tumpel S., Sanz-Ezquerro J.J., Isaac A., Eblaghie M.C., Dobson J., Tickle C.
    Dev. Biol. 250:251-262(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.

Entry informationi

Entry nameiQ8CJ82_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ82
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.