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Q8CJ82

- Q8CJ82_MOUSE

UniProt

Q8CJ82 - Q8CJ82_MOUSE

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Protein
Submitted name:

TBX3

Gene

Tbx3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. atrioventricular bundle cell differentiation Source: MGI
  2. blood vessel development Source: MGI
  3. branching involved in mammary gland duct morphogenesis Source: MGI
  4. cardiac muscle cell differentiation Source: MGI
  5. cardiac muscle cell fate commitment Source: MGI
  6. cell aging Source: MGI
  7. forelimb morphogenesis Source: MGI
  8. heart looping Source: MGI
  9. heart morphogenesis Source: MGI
  10. in utero embryonic development Source: MGI
  11. limbic system development Source: MGI
  12. limb morphogenesis Source: MGI
  13. mammary gland development Source: MGI
  14. mammary placode formation Source: MGI
  15. negative regulation of epithelial cell differentiation Source: MGI
  16. negative regulation of transcription, DNA-templated Source: MGI
  17. organ morphogenesis Source: MGI
  18. outflow tract morphogenesis Source: MGI
  19. palate development Source: MGI
  20. positive regulation of stem cell proliferation Source: MGI
  21. positive regulation of transcription, DNA-templated Source: MGI
  22. regulation of cell proliferation Source: MGI
  23. sinoatrial node cell development Source: MGI
  24. specification of organ position Source: MGI
  25. stem cell maintenance Source: MGI
  26. transcription, DNA-templated Source: UniProtKB-KW
  27. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TBX3Imported
Gene namesi
Name:Tbx3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98495. Tbx3.

Subcellular locationi

Nucleus SAAS annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8CJ82.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018748.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains T-box DNA-binding domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG004599.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8CJ82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EMVITKSGRR MFPPFKVRCS GLDKKAKYIL LMDIIAADDC RYKFHNSRWM
60 70 80 90 100
VAGKADPEMP KRMYIHPDSP ATGEQWMSKV VTFHKLKLTN NISDKHGFTI
110 120 130 140 150
LNSMHKYQPR FHIVRANDIL KLPYSTFRTY LFPETEFIAV TAYQNDKITQ
160
LKIDNNPFAK GFRDIGHC
Length:168
Mass (Da):19,634
Last modified:March 1, 2003 - v1
Checksum:i914EA2F26358E5BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei168 – 1681Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF429310 mRNA. Translation: AAN37692.1.
UniGeneiMm.219139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF429310 mRNA. Translation: AAN37692.1 .
UniGenei Mm.219139.

3D structure databases

ProteinModelPortali Q8CJ82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000018748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98495. Tbx3.

Phylogenomic databases

HOVERGENi HBG004599.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q8CJ82.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00938. BRACHYURY.
PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development."
    Tumpel S., Sanz-Ezquerro J.J., Isaac A., Eblaghie M.C., Dobson J., Tickle C.
    Dev. Biol. 250:251-262(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.

Entry informationi

Entry nameiQ8CJ82_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ82
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)