Q8CJ82 (Q8CJ82_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TBX3 EMBL AAN37692.1

Gene names

Name:

Tbx3 EMBL AAN37692.1 MGI 98495

Organism

Mus musculus (Mouse) EMBL AAN37692.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	168 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 T-box DNA-binding domain. SAAS SAAS018186

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS018186
Cellular component	Nucleus SAAS SAAS018186
Ligand	DNA-binding SAAS SAAS018186
Gene Ontology (GO)
Biological_process	atrioventricular bundle cell differentiation Inferred from mutant phenotype PubMed 18467625. Source: MGI blood vessel development Inferred from mutant phenotype PubMed 12668638. Source: MGI branching involved in mammary gland duct morphogenesis Inferred from mutant phenotype PubMed 16222716. Source: MGI cardiac muscle cell fate commitment Inferred from mutant phenotype PubMed 18467625. Source: MGI cell aging Inferred from direct assay PubMed 11748239. Source: MGI forelimb morphogenesis Inferred from sequence orthology PubMed 9207801. Source: MGI heart looping Inferred from mutant phenotype PubMed 17460765PubMed 18723448. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 17473172. Source: MGI limbic system development Inferred from mutant phenotype PubMed 17473172. Source: MGI mammary placode formation Inferred from direct assay PubMed 17071745. Source: MGI negative regulation of epithelial cell differentiation Inferred from mutant phenotype PubMed 18356246. Source: MGI negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 11748239. Source: MGI outflow tract morphogenesis Inferred from mutant phenotype PubMed 18723448. Source: MGI palate development Inferred from genetic interaction PubMed 19769959. Source: MGI positive regulation of stem cell proliferation Inferred from mutant phenotype PubMed 18356246. Source: MGI positive regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 17473172. Source: MGI sinoatrial node cell development Inferred from mutant phenotype PubMed 19096026. Source: MGI specification of organ position Inferred from direct assay PubMed 17071745. Source: MGI stem cell maintenance Inferred from mutant phenotype PubMed 18356246. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW ventricular septum morphogenesis Inferred from mutant phenotype PubMed 18467625. Source: MGI
Cellular_component	nucleus Inferred from direct assay PubMed 18534921PubMed 18723448PubMed 19765559. Source: MGI
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 17473172. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAN37692.1
	Non-terminal residue	168	1	EMBL AAN37692.1

Sequences

	Sequence		Length	Mass (Da)
	Q8CJ82 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 914EA2F26358E5BC	FASTA	168	19,634
	10 20 30 40 50 60 EMVITKSGRR MFPPFKVRCS GLDKKAKYIL LMDIIAADDC RYKFHNSRWM VAGKADPEMP 70 80 90 100 110 120 KRMYIHPDSP ATGEQWMSKV VTFHKLKLTN NISDKHGFTI LNSMHKYQPR FHIVRANDIL 130 140 150 160 KLPYSTFRTY LFPETEFIAV TAYQNDKITQ LKIDNNPFAK GFRDIGHC

References

[1]	"Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development." Tumpel S., Sanz-Ezquerro J.J., Isaac A., Eblaghie M.C., Dobson J., Tickle C. Dev. Biol. 250:251-262(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CD-1 EMBL AAN37692.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF429310 mRNA. Translation: AAN37692.1.
IPI	IPI00108117.
UniGene	Mm.219139.
3D structure databases
HSSP	HSSP built from PDB template 1H6F based on UniProtKB O15119.
ProteinModelPortal	Q8CJ82.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000018748.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:98495. Tbx3.
Phylogenomic databases
HOVERGEN	HBG004599.
Gene expression databases
Genevestigator	Q8CJ82.
Family and domain databases
Gene3D	2.60.40.820. 1 hit.
InterPro	IPR008967. p53-like_TF_DNA-bd. IPR002070. TF_Brachyury. IPR001699. TF_T-box. IPR018186. TF_T-box_CS. [Graphical view]
PANTHER	PTHR11267. PTHR11267. 1 hit.
Pfam	PF00907. T-box. 1 hit. [Graphical view]
PRINTS	PR00938. BRACHYURY. PR00937. TBOX.
SMART	SM00425. TBOX. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS01264. TBOX_2. 1 hit. PS50252. TBOX_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q8CJ82_MOUSE

Accession

Primary (citable) accession number: Q8CJ82

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)