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Q8CJ82

- Q8CJ82_MOUSE

UniProt

Q8CJ82 - Q8CJ82_MOUSE

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Protein
Submitted name:

TBX3

Gene
Tbx3
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. atrioventricular bundle cell differentiation Source: MGI
  2. blood vessel development Source: MGI
  3. branching involved in mammary gland duct morphogenesis Source: MGI
  4. cardiac muscle cell differentiation Source: MGI
  5. cardiac muscle cell fate commitment Source: MGI
  6. cell aging Source: MGI
  7. forelimb morphogenesis Source: MGI
  8. heart looping Source: MGI
  9. heart morphogenesis Source: MGI
  10. in utero embryonic development Source: MGI
  11. limbic system development Source: MGI
  12. limb morphogenesis Source: MGI
  13. mammary gland development Source: MGI
  14. mammary placode formation Source: MGI
  15. negative regulation of epithelial cell differentiation Source: MGI
  16. negative regulation of transcription, DNA-templated Source: MGI
  17. organ morphogenesis Source: MGI
  18. outflow tract morphogenesis Source: MGI
  19. palate development Source: MGI
  20. positive regulation of stem cell proliferation Source: MGI
  21. positive regulation of transcription, DNA-templated Source: MGI
  22. regulation of cell proliferation Source: MGI
  23. sinoatrial node cell development Source: MGI
  24. specification of organ position Source: MGI
  25. stem cell maintenance Source: MGI
  26. transcription, DNA-templated Source: UniProtKB-KW
  27. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
TBX3Imported
Gene namesi
Name:Tbx3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98495. Tbx3.

Subcellular locationi

Nucleus By similarity SAAS annotations

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ8CJ82.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018748.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ82.

Family & Domainsi

Sequence similaritiesi

Contains T-box DNA-binding domain.SAAS annotations

Phylogenomic databases

HOVERGENiHBG004599.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8CJ82-1 [UniParc]FASTAAdd to Basket

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EMVITKSGRR MFPPFKVRCS GLDKKAKYIL LMDIIAADDC RYKFHNSRWM    50
VAGKADPEMP KRMYIHPDSP ATGEQWMSKV VTFHKLKLTN NISDKHGFTI 100
LNSMHKYQPR FHIVRANDIL KLPYSTFRTY LFPETEFIAV TAYQNDKITQ 150
LKIDNNPFAK GFRDIGHC 168
Length:168
Mass (Da):19,634
Last modified:March 1, 2003 - v1
Checksum:i914EA2F26358E5BC
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei168 – 1681Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF429310 mRNA. Translation: AAN37692.1.
UniGeneiMm.219139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF429310 mRNA. Translation: AAN37692.1 .
UniGenei Mm.219139.

3D structure databases

ProteinModelPortali Q8CJ82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000018748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98495. Tbx3.

Phylogenomic databases

HOVERGENi HBG004599.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q8CJ82.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00938. BRACHYURY.
PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development."
    Tumpel S., Sanz-Ezquerro J.J., Isaac A., Eblaghie M.C., Dobson J., Tickle C.
    Dev. Biol. 250:251-262(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.

Entry informationi

Entry nameiQ8CJ82_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ82
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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