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Q8CJ82

- Q8CJ82_MOUSE

UniProt

Q8CJ82 - Q8CJ82_MOUSE

Protein
Submitted name:

TBX3

Gene

Tbx3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. atrioventricular bundle cell differentiation Source: MGI
    2. blood vessel development Source: MGI
    3. branching involved in mammary gland duct morphogenesis Source: MGI
    4. cardiac muscle cell differentiation Source: MGI
    5. cardiac muscle cell fate commitment Source: MGI
    6. cell aging Source: MGI
    7. forelimb morphogenesis Source: MGI
    8. heart looping Source: MGI
    9. heart morphogenesis Source: MGI
    10. in utero embryonic development Source: MGI
    11. limbic system development Source: MGI
    12. limb morphogenesis Source: MGI
    13. mammary gland development Source: MGI
    14. mammary placode formation Source: MGI
    15. negative regulation of epithelial cell differentiation Source: MGI
    16. negative regulation of transcription, DNA-templated Source: MGI
    17. organ morphogenesis Source: MGI
    18. outflow tract morphogenesis Source: MGI
    19. palate development Source: MGI
    20. positive regulation of stem cell proliferation Source: MGI
    21. positive regulation of transcription, DNA-templated Source: MGI
    22. regulation of cell proliferation Source: MGI
    23. sinoatrial node cell development Source: MGI
    24. specification of organ position Source: MGI
    25. stem cell maintenance Source: MGI
    26. transcription, DNA-templated Source: UniProtKB-KW
    27. ventricular septum morphogenesis Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TBX3Imported
    Gene namesi
    Name:Tbx3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98495. Tbx3.

    Subcellular locationi

    Nucleus SAAS annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8CJ82.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000018748.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CJ82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains T-box DNA-binding domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG004599.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8CJ82-1 [UniParc]FASTAAdd to Basket

    « Hide

    EMVITKSGRR MFPPFKVRCS GLDKKAKYIL LMDIIAADDC RYKFHNSRWM    50
    VAGKADPEMP KRMYIHPDSP ATGEQWMSKV VTFHKLKLTN NISDKHGFTI 100
    LNSMHKYQPR FHIVRANDIL KLPYSTFRTY LFPETEFIAV TAYQNDKITQ 150
    LKIDNNPFAK GFRDIGHC 168
    Length:168
    Mass (Da):19,634
    Last modified:March 1, 2003 - v1
    Checksum:i914EA2F26358E5BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei168 – 1681Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF429310 mRNA. Translation: AAN37692.1.
    UniGeneiMm.219139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF429310 mRNA. Translation: AAN37692.1 .
    UniGenei Mm.219139.

    3D structure databases

    ProteinModelPortali Q8CJ82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000018748.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98495. Tbx3.

    Phylogenomic databases

    HOVERGENi HBG004599.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8CJ82.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development."
      Tumpel S., Sanz-Ezquerro J.J., Isaac A., Eblaghie M.C., Dobson J., Tickle C.
      Dev. Biol. 250:251-262(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CD-1Imported.

    Entry informationi

    Entry nameiQ8CJ82_MOUSE
    AccessioniPrimary (citable) accession number: Q8CJ82
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)