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Protein

Interleukin-19

Gene

Il19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • interleukin-6 biosynthetic process Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of JAK-STAT cascade Source: GO_Central
  • reactive oxygen species metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-19
Short name:
IL-19
Gene namesi
Name:Il19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1890472. Il19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 176152Interleukin-19PRO_0000015380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 120By similarity
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi74 ↔ 126By similarity
Disulfide bondi75 ↔ 128By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CJ70.
PRIDEiQ8CJ70.

PTM databases

PhosphoSiteiQ8CJ70.

Expressioni

Gene expression databases

BgeeiQ8CJ70.
CleanExiMM_IL19.
ExpressionAtlasiQ8CJ70. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016668.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ70.
SMRiQ8CJ70. Positions 23-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26818.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ8CJ70.
KOiK05444.
OMAiLDVFLAW.
OrthoDBiEOG7060SK.
PhylomeDBiQ8CJ70.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020421. IL-19.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01934. INTRLEUKIN19.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT
60 70 80 90 100
KDTFKNVTIL SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL
110 120 130 140 150
RRISSIANSF LCVQKSLERC QVHRQCNCSQ EATNATRIIH DNYNQLEVSS
160 170
AALKSLGELN ILLAWIDRNH LETPAA
Length:176
Mass (Da):20,288
Last modified:March 1, 2003 - v1
Checksum:i73E6C1BC54077FDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453945 mRNA. Translation: AAN40905.1.
CCDSiCCDS15264.1.
RefSeqiNP_001009940.1. NM_001009940.1.
XP_006529769.1. XM_006529706.1.
UniGeneiMm.131480.

Genome annotation databases

EnsembliENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
ENSMUST00000187410; ENSMUSP00000139406; ENSMUSG00000016524.
GeneIDi329244.
KEGGimmu:329244.
UCSCiuc007cms.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453945 mRNA. Translation: AAN40905.1.
CCDSiCCDS15264.1.
RefSeqiNP_001009940.1. NM_001009940.1.
XP_006529769.1. XM_006529706.1.
UniGeneiMm.131480.

3D structure databases

ProteinModelPortaliQ8CJ70.
SMRiQ8CJ70. Positions 23-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016668.

PTM databases

PhosphoSiteiQ8CJ70.

Proteomic databases

PaxDbiQ8CJ70.
PRIDEiQ8CJ70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
ENSMUST00000187410; ENSMUSP00000139406; ENSMUSG00000016524.
GeneIDi329244.
KEGGimmu:329244.
UCSCiuc007cms.1. mouse.

Organism-specific databases

CTDi29949.
MGIiMGI:1890472. Il19.

Phylogenomic databases

eggNOGiNOG26818.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ8CJ70.
KOiK05444.
OMAiLDVFLAW.
OrthoDBiEOG7060SK.
PhylomeDBiQ8CJ70.
TreeFamiTF333253.

Miscellaneous databases

NextBioi398640.
PROiQ8CJ70.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CJ70.
CleanExiMM_IL19.
ExpressionAtlasiQ8CJ70. baseline.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020421. IL-19.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01934. INTRLEUKIN19.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha."
    Liao Y.-C., Liang W.G., Chen F.W., Hsu J.H., Yang J.J., Chang M.-S.
    J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Swiss Webster / NIH.

Entry informationi

Entry nameiIL19_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.