Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8CJ70

- IL19_MOUSE

UniProt

Q8CJ70 - IL19_MOUSE

Protein

Interleukin-19

Gene

Il19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.1 Publication

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. interleukin-6 biosynthetic process Source: MGI
    3. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
    4. positive regulation of apoptotic signaling pathway Source: MGI
    5. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
    6. reactive oxygen species metabolic process Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-19
    Short name:
    IL-19
    Gene namesi
    Name:Il19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1890472. Il19.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 176152Interleukin-19PRO_0000015380Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 120By similarity
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi74 ↔ 126By similarity
    Disulfide bondi75 ↔ 128By similarity
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8CJ70.
    PRIDEiQ8CJ70.

    PTM databases

    PhosphoSiteiQ8CJ70.

    Expressioni

    Gene expression databases

    BgeeiQ8CJ70.
    CleanExiMM_IL19.
    GenevestigatoriQ8CJ70.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CJ70.
    SMRiQ8CJ70. Positions 23-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26818.
    GeneTreeiENSGT00410000025637.
    HOGENOMiHOG000113033.
    HOVERGENiHBG108002.
    InParanoidiQ8CJ70.
    KOiK05444.
    OMAiLDVFLAW.
    OrthoDBiEOG7060SK.
    PhylomeDBiQ8CJ70.
    TreeFamiTF333253.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR020421. IL-19.
    [Graphical view]
    PANTHERiPTHR11585. PTHR11585. 1 hit.
    PfamiPF00726. IL10. 1 hit.
    [Graphical view]
    PRINTSiPR01934. INTRLEUKIN19.
    SMARTiSM00188. IL10. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CJ70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT    50
    KDTFKNVTIL SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL 100
    RRISSIANSF LCVQKSLERC QVHRQCNCSQ EATNATRIIH DNYNQLEVSS 150
    AALKSLGELN ILLAWIDRNH LETPAA 176
    Length:176
    Mass (Da):20,288
    Last modified:March 1, 2003 - v1
    Checksum:i73E6C1BC54077FDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453945 mRNA. Translation: AAN40905.1.
    CCDSiCCDS15264.1.
    RefSeqiNP_001009940.1. NM_001009940.1.
    XP_006529769.1. XM_006529706.1.
    UniGeneiMm.131480.

    Genome annotation databases

    EnsembliENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
    ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
    GeneIDi329244.
    KEGGimmu:329244.
    UCSCiuc007cms.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF453945 mRNA. Translation: AAN40905.1 .
    CCDSi CCDS15264.1.
    RefSeqi NP_001009940.1. NM_001009940.1.
    XP_006529769.1. XM_006529706.1.
    UniGenei Mm.131480.

    3D structure databases

    ProteinModelPortali Q8CJ70.
    SMRi Q8CJ70. Positions 23-170.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8CJ70.

    Proteomic databases

    PaxDbi Q8CJ70.
    PRIDEi Q8CJ70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016668 ; ENSMUSP00000016668 ; ENSMUSG00000016524 .
    ENSMUST00000112465 ; ENSMUSP00000108084 ; ENSMUSG00000016524 .
    GeneIDi 329244.
    KEGGi mmu:329244.
    UCSCi uc007cms.1. mouse.

    Organism-specific databases

    CTDi 29949.
    MGIi MGI:1890472. Il19.

    Phylogenomic databases

    eggNOGi NOG26818.
    GeneTreei ENSGT00410000025637.
    HOGENOMi HOG000113033.
    HOVERGENi HBG108002.
    InParanoidi Q8CJ70.
    KOi K05444.
    OMAi LDVFLAW.
    OrthoDBi EOG7060SK.
    PhylomeDBi Q8CJ70.
    TreeFami TF333253.

    Miscellaneous databases

    NextBioi 398640.
    PROi Q8CJ70.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CJ70.
    CleanExi MM_IL19.
    Genevestigatori Q8CJ70.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    IPR020421. IL-19.
    [Graphical view ]
    PANTHERi PTHR11585. PTHR11585. 1 hit.
    Pfami PF00726. IL10. 1 hit.
    [Graphical view ]
    PRINTSi PR01934. INTRLEUKIN19.
    SMARTi SM00188. IL10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha."
      Liao Y.-C., Liang W.G., Chen F.W., Hsu J.H., Yang J.J., Chang M.-S.
      J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: Swiss Webster / NIH.

    Entry informationi

    Entry nameiIL19_MOUSE
    AccessioniPrimary (citable) accession number: Q8CJ70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3