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Q8CJ70

- IL19_MOUSE

UniProt

Q8CJ70 - IL19_MOUSE

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Protein

Interleukin-19

Gene

Il19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.1 Publication

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. interleukin-6 biosynthetic process Source: MGI
  3. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  4. positive regulation of apoptotic signaling pathway Source: MGI
  5. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  6. reactive oxygen species metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-19
Short name:
IL-19
Gene namesi
Name:Il19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1890472. Il19.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 176152Interleukin-19PRO_0000015380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 120By similarity
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi74 ↔ 126By similarity
Disulfide bondi75 ↔ 128By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CJ70.
PRIDEiQ8CJ70.

PTM databases

PhosphoSiteiQ8CJ70.

Expressioni

Gene expression databases

BgeeiQ8CJ70.
CleanExiMM_IL19.
GenevestigatoriQ8CJ70.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ70.
SMRiQ8CJ70. Positions 23-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26818.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ8CJ70.
KOiK05444.
OMAiLDVFLAW.
OrthoDBiEOG7060SK.
PhylomeDBiQ8CJ70.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020421. IL-19.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01934. INTRLEUKIN19.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJ70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT
60 70 80 90 100
KDTFKNVTIL SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL
110 120 130 140 150
RRISSIANSF LCVQKSLERC QVHRQCNCSQ EATNATRIIH DNYNQLEVSS
160 170
AALKSLGELN ILLAWIDRNH LETPAA
Length:176
Mass (Da):20,288
Last modified:March 1, 2003 - v1
Checksum:i73E6C1BC54077FDC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF453945 mRNA. Translation: AAN40905.1.
CCDSiCCDS15264.1.
RefSeqiNP_001009940.1. NM_001009940.1.
XP_006529769.1. XM_006529706.1.
UniGeneiMm.131480.

Genome annotation databases

EnsembliENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
ENSMUST00000187410; ENSMUSP00000139406; ENSMUSG00000016524.
GeneIDi329244.
KEGGimmu:329244.
UCSCiuc007cms.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF453945 mRNA. Translation: AAN40905.1 .
CCDSi CCDS15264.1.
RefSeqi NP_001009940.1. NM_001009940.1.
XP_006529769.1. XM_006529706.1.
UniGenei Mm.131480.

3D structure databases

ProteinModelPortali Q8CJ70.
SMRi Q8CJ70. Positions 23-170.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8CJ70.

Proteomic databases

PaxDbi Q8CJ70.
PRIDEi Q8CJ70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016668 ; ENSMUSP00000016668 ; ENSMUSG00000016524 .
ENSMUST00000112465 ; ENSMUSP00000108084 ; ENSMUSG00000016524 .
ENSMUST00000187410 ; ENSMUSP00000139406 ; ENSMUSG00000016524 .
GeneIDi 329244.
KEGGi mmu:329244.
UCSCi uc007cms.1. mouse.

Organism-specific databases

CTDi 29949.
MGIi MGI:1890472. Il19.

Phylogenomic databases

eggNOGi NOG26818.
GeneTreei ENSGT00410000025637.
HOGENOMi HOG000113033.
HOVERGENi HBG108002.
InParanoidi Q8CJ70.
KOi K05444.
OMAi LDVFLAW.
OrthoDBi EOG7060SK.
PhylomeDBi Q8CJ70.
TreeFami TF333253.

Miscellaneous databases

NextBioi 398640.
PROi Q8CJ70.
SOURCEi Search...

Gene expression databases

Bgeei Q8CJ70.
CleanExi MM_IL19.
Genevestigatori Q8CJ70.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020421. IL-19.
[Graphical view ]
PANTHERi PTHR11585. PTHR11585. 1 hit.
Pfami PF00726. IL10. 1 hit.
[Graphical view ]
PRINTSi PR01934. INTRLEUKIN19.
SMARTi SM00188. IL10. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha."
    Liao Y.-C., Liang W.G., Chen F.W., Hsu J.H., Yang J.J., Chang M.-S.
    J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Swiss Webster / NIH.

Entry informationi

Entry nameiIL19_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3