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Protein

Interleukin-19

Gene

Il19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • interleukin-6 biosynthetic process Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of JAK-STAT cascade Source: GO_Central
  • reactive oxygen species metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-8854691. Interleukin-19, 20, 22, 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-19
Short name:
IL-19
Gene namesi
Name:Il19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1890472. Il19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001538025 – 176Interleukin-19Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 120By similarity
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi74 ↔ 126By similarity
Disulfide bondi75 ↔ 128By similarity
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CJ70.
PRIDEiQ8CJ70.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016524.
CleanExiMM_IL19.
ExpressionAtlasiQ8CJ70. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016668.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ70.
SMRiQ8CJ70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWQW. Eukaryota.
ENOG41115RG. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ8CJ70.
KOiK05444.
OMAiLDVFLAW.
OrthoDBiEOG091G0Q0Q.
PhylomeDBiQ8CJ70.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020421. IL-19.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01934. INTRLEUKIN19.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT
60 70 80 90 100
KDTFKNVTIL SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL
110 120 130 140 150
RRISSIANSF LCVQKSLERC QVHRQCNCSQ EATNATRIIH DNYNQLEVSS
160 170
AALKSLGELN ILLAWIDRNH LETPAA
Length:176
Mass (Da):20,288
Last modified:March 1, 2003 - v1
Checksum:i73E6C1BC54077FDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453945 mRNA. Translation: AAN40905.1.
CCDSiCCDS15264.1.
RefSeqiNP_001009940.1. NM_001009940.1.
XP_006529769.1. XM_006529706.1.
UniGeneiMm.131480.

Genome annotation databases

EnsembliENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
ENSMUST00000187410; ENSMUSP00000139406; ENSMUSG00000016524.
GeneIDi329244.
KEGGimmu:329244.
UCSCiuc007cms.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453945 mRNA. Translation: AAN40905.1.
CCDSiCCDS15264.1.
RefSeqiNP_001009940.1. NM_001009940.1.
XP_006529769.1. XM_006529706.1.
UniGeneiMm.131480.

3D structure databases

ProteinModelPortaliQ8CJ70.
SMRiQ8CJ70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016668.

Proteomic databases

PaxDbiQ8CJ70.
PRIDEiQ8CJ70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
ENSMUST00000187410; ENSMUSP00000139406; ENSMUSG00000016524.
GeneIDi329244.
KEGGimmu:329244.
UCSCiuc007cms.1. mouse.

Organism-specific databases

CTDi29949.
MGIiMGI:1890472. Il19.

Phylogenomic databases

eggNOGiENOG410IWQW. Eukaryota.
ENOG41115RG. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ8CJ70.
KOiK05444.
OMAiLDVFLAW.
OrthoDBiEOG091G0Q0Q.
PhylomeDBiQ8CJ70.
TreeFamiTF333253.

Enzyme and pathway databases

ReactomeiR-MMU-8854691. Interleukin-19, 20, 22, 24.

Miscellaneous databases

PROiQ8CJ70.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016524.
CleanExiMM_IL19.
ExpressionAtlasiQ8CJ70. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020421. IL-19.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01934. INTRLEUKIN19.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL19_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.