Q8CJ70 (IL19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-19
Short name=IL-19

Gene names

Name:

Il19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Ref.1
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-10 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis Inferred from direct assay Ref.1. Source: MGI interleukin-6 biosynthetic process Inferred from direct assay Ref.1. Source: MGI reactive oxygen species metabolic process Inferred from direct assay Ref.1. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 176	152	Interleukin-19		PRO_0000015380
Amino acid modifications
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Disulfide bond	28 ↔ 120		By similarity
	Disulfide bond	74 ↔ 126		By similarity
	Disulfide bond	75 ↔ 128		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CJ70 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 73E6C1BC54077FDC	FASTA	176	20,288
	10 20 30 40 50 60 MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT KDTFKNVTIL 70 80 90 100 110 120 SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL RRISSIANSF LCVQKSLERC 130 140 150 160 170 QVHRQCNCSQ EATNATRIIH DNYNQLEVSS AALKSLGELN ILLAWIDRNH LETPAA

References

[1]	"IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha." Liao Y.-C., Liang W.G., Chen F.W., Hsu J.H., Yang J.J., Chang M.-S. J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Strain: Swiss Webster / NIH.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF453945 mRNA. Translation: AAN40905.1.
IPI	IPI00229944.
RefSeq	NP_001009940.1. NM_001009940.1.
UniGene	Mm.131480.
3D structure databases
ProteinModelPortal	Q8CJ70.
SMR	Q8CJ70. Positions 23-170.
ModBase	Search...
PTM databases
PhosphoSite	Q8CJ70.
Proteomic databases
PaxDb	Q8CJ70.
PRIDE	Q8CJ70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524. ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
GeneID	329244.
KEGG	mmu:329244.
UCSC	uc007cms.1. mouse.
Organism-specific databases
CTD	29949.
MGI	MGI:1890472. Il19.
Phylogenomic databases
eggNOG	NOG26818.
GeneTree	ENSGT00410000025637.
HOGENOM	HOG000113033.
HOVERGEN	HBG108002.
InParanoid	Q8CJ70.
KO	K05444.
OMA	LDVFLAW.
OrthoDB	EOG4XWG07.
Gene expression databases
ArrayExpress	Q8CJ70.
Bgee	Q8CJ70.
CleanEx	MM_IL19.
Genevestigator	Q8CJ70.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR020443. Interleukin-10/19/20/24. IPR020423. Interleukin-10_CS. IPR020421. Interleukin-19. [Graphical view]
PANTHER	PTHR11585. PTHR11585. 1 hit.
Pfam	PF00726. IL10. 1 hit. [Graphical view]
PRINTS	PR01934. INTRLEUKIN19.
SMART	SM00188. IL10. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00520. INTERLEUKIN_10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	398640.
SOURCE	Search...

Entry information

Entry name

IL19_MOUSE

Accession

Primary (citable) accession number: Q8CJ70

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program