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Q8CJ70 (IL19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-19

Short name=IL-19
Gene names
Name:Il19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Ref.1

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 176152Interleukin-19
PRO_0000015380

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Disulfide bond28 ↔ 120 By similarity
Disulfide bond74 ↔ 126 By similarity
Disulfide bond75 ↔ 128 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CJ70 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 73E6C1BC54077FDC

FASTA17620,288
        10         20         30         40         50         60 
MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT KDTFKNVTIL 

        70         80         90        100        110        120 
SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL RRISSIANSF LCVQKSLERC 

       130        140        150        160        170 
QVHRQCNCSQ EATNATRIIH DNYNQLEVSS AALKSLGELN ILLAWIDRNH LETPAA 

« Hide

References

[1]"IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha."
Liao Y.-C., Liang W.G., Chen F.W., Hsu J.H., Yang J.J., Chang M.-S.
J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: Swiss Webster / NIH.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF453945 mRNA. Translation: AAN40905.1.
CCDSCCDS15264.1.
RefSeqNP_001009940.1. NM_001009940.1.
XP_006529769.1. XM_006529706.1.
UniGeneMm.131480.

3D structure databases

ProteinModelPortalQ8CJ70.
SMRQ8CJ70. Positions 23-170.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8CJ70.

Proteomic databases

PaxDbQ8CJ70.
PRIDEQ8CJ70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
GeneID329244.
KEGGmmu:329244.
UCSCuc007cms.1. mouse.

Organism-specific databases

CTD29949.
MGIMGI:1890472. Il19.

Phylogenomic databases

eggNOGNOG26818.
GeneTreeENSGT00410000025637.
HOGENOMHOG000113033.
HOVERGENHBG108002.
InParanoidQ8CJ70.
KOK05444.
OMALDVFLAW.
OrthoDBEOG7060SK.
PhylomeDBQ8CJ70.
TreeFamTF333253.

Gene expression databases

BgeeQ8CJ70.
CleanExMM_IL19.
GenevestigatorQ8CJ70.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020421. IL-19.
[Graphical view]
PANTHERPTHR11585. PTHR11585. 1 hit.
PfamPF00726. IL10. 1 hit.
[Graphical view]
PRINTSPR01934. INTRLEUKIN19.
SMARTSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio398640.
PROQ8CJ70.
SOURCESearch...

Entry information

Entry nameIL19_MOUSE
AccessionPrimary (citable) accession number: Q8CJ70
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot